Objective To investigate the prevalence of gout and its associated factors in populations in Beijing. Methods A cross-sectional study of gout was carried out in state-employees who had yearly health examination at Peking Union Medical College Hospital in Beijing,China from September to December 2005. The prevalence of gout was calculated in the population. Data were further analyzed by multivariate logistic regression models to find associated factors of gout. Results The prevalence of gout in the population was 1.0%,and were 1.5% and 0.3% for men and women respectively. Bivariate and multivariate logistic regression analysis found that male gender (OR 15.07,95%CI 1.79～127.19),hard liquor (OR 4.93,95%CI 1.41～17.31 for ≥7 beverages per week),diuretics (OR 6.72,95%CI 2.34～19.34),waist obesity (OR 4.38,95%CI 1.33～14.43),and hypercholesterolemia (OR 3.63,95%CI 1.23～10.67 for serum cholesterol 5.17～6.21mmol/L) were associated with increased prevalence of gout,whereas products of bean curd (OR 0.21,95%CI 0.07～0.59) were associated with reduced prevalence of gout. Conclusion Male gender,hard liquor,diuretics,waist obesity and hyperchol-esterolemia may be associated with the increased risk of gout,whereas products of bean curd may be associated with the reduced risk of gout.

Objective To study the relationship between serum uric acid and left atrial size in male patients with essential hypertension.Methods From June 2015 to December 2016,298 males with essential hypertension in the People's Hospital of Guangdong Province were selected.They were divided into normal left atrial group and enlarged left atrial group based on the size of left atrial diameter.The fasting blood glucose,serum lipid,serum uric acid,hepatic and renal function and blood pressure were measured by routine methods,and multivariate logistic regres-sion was used to analyze.Results The average age and serum uric acid level of 298 males with essential hypertension were (55.29 ±8.48)years old and (488.93 ±112.46)μmol/L.There were 47 cases with enlarged left atrial.The serum uric acid level in the enlarged left atrial group was significant higher than that in the normal left atrial group [(512.21±90.82 )μmol/L vs.(474.38 ±94.26 )μmol/L,t ＝9.34,P＜0.001].Pearson correlation analysis showed that serum uric acid level was positively associated with left atrial diameter(r＝0.589,P＜0.001).Multiple logistic regression analysis showed that the serum uric acid level was a risk factor for enlarged left atrial(OR＝1.894, 95%CI:1.13,2.69;P＜0.001).Conclusion Serum uric acid level is positively correlated with left atrial size in male patients with essential hypertension,and is a risk factor for enlarged left atrial.

Objective To investigate the correlation between the level of oxidative stress indica-tors in placental tissues and placental perfusion level in twin-to-twin transfusion syndrome(TTTS).Methods A total of 105 cases of dichorionic monoamniotic monozygotic twin pregnant women were included in the study.They were divided into control group of 90 cases and observation group of 15 cases based on whether TTTS occurred during pregnancy.The levels of oxidative stress indicators[malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-PX)]in placental tissues below the attachment points of the two umbilical cords in the two groups were detec-ted.The maximum diameters of arterio-arterial(AA)anastomosis,veno-venous(VV)anastomosis,and arterio-venous(AV)anastomosis,as well as the difference ratio of placental tissue areas(PTD),were compared between the two groups.The correlation between the levels of oxidative stress indicators in placental tissues and placental perfusion level was analyzed.Results Compared with placental A and placental B in the control group,the MDA level in the placental tissues of the blood supply end and the blood recipient end in the observation group was increased,while the SOD and GSH-PX levels were decreased,and the maximum diameter of AA anastomosis was reduced,there were statistically significant differences(P＜0.05).In the observation group,the MDA level in the placental tissues of the blood supply end was higher than that of the blood recipient end,the SOD and GSH-PX levels were lower than those of the blood recipient end,and the maximum diameter of AA anastomo-sis was smaller than that of the blood recipient end,with statistically significant differences(P＜0.05).The maximum diameters of AV anastomosis and PTD in the observation group were larger than those in the control group(P＜0.05).There was no significant difference in the maximum di-ameter of VV anastomosis between the two groups(P＞0.05).Pearson correlation analysis showed that there were no significant correlations of MDA,SOD and GSH-PX levels with the maximum di-ameter of AA anastomosis and PTD in the placental tissues of the control group(P＞0.05).In the placental tissues of the blood supply end and the blood recipient end in the observation group,MDA levels showed a strong negative correlation with the maximum diameter of AA anastomosis and a strong positive correlation with the maximum diameter of AV anastomosis and PTD(P＜0.05).SOD and GSH-PX levels showed strong positive correlations with the maximum diameter of AA anas-tomosis and strong negative correlations with the maximum diamete of AV anastomosis and PTD(P＜0.05).Conclusion There is a significant imbalance of oxidative stress in placental tissues of TTTS pregnant women,and the decrease in antioxidant activity of placental tissues may be an impor-tant cause of placental perfusion injury.

Objective To investigate the correlation between the level of oxidative stress indica-tors in placental tissues and placental perfusion level in twin-to-twin transfusion syndrome(TTTS).Methods A total of 105 cases of dichorionic monoamniotic monozygotic twin pregnant women were included in the study.They were divided into control group of 90 cases and observation group of 15 cases based on whether TTTS occurred during pregnancy.The levels of oxidative stress indicators[malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-PX)]in placental tissues below the attachment points of the two umbilical cords in the two groups were detec-ted.The maximum diameters of arterio-arterial(AA)anastomosis,veno-venous(VV)anastomosis,and arterio-venous(AV)anastomosis,as well as the difference ratio of placental tissue areas(PTD),were compared between the two groups.The correlation between the levels of oxidative stress indicators in placental tissues and placental perfusion level was analyzed.Results Compared with placental A and placental B in the control group,the MDA level in the placental tissues of the blood supply end and the blood recipient end in the observation group was increased,while the SOD and GSH-PX levels were decreased,and the maximum diameter of AA anastomosis was reduced,there were statistically significant differences(P＜0.05).In the observation group,the MDA level in the placental tissues of the blood supply end was higher than that of the blood recipient end,the SOD and GSH-PX levels were lower than those of the blood recipient end,and the maximum diameter of AA anastomo-sis was smaller than that of the blood recipient end,with statistically significant differences(P＜0.05).The maximum diameters of AV anastomosis and PTD in the observation group were larger than those in the control group(P＜0.05).There was no significant difference in the maximum di-ameter of VV anastomosis between the two groups(P＞0.05).Pearson correlation analysis showed that there were no significant correlations of MDA,SOD and GSH-PX levels with the maximum di-ameter of AA anastomosis and PTD in the placental tissues of the control group(P＞0.05).In the placental tissues of the blood supply end and the blood recipient end in the observation group,MDA levels showed a strong negative correlation with the maximum diameter of AA anastomosis and a strong positive correlation with the maximum diameter of AV anastomosis and PTD(P＜0.05).SOD and GSH-PX levels showed strong positive correlations with the maximum diameter of AA anas-tomosis and strong negative correlations with the maximum diamete of AV anastomosis and PTD(P＜0.05).Conclusion There is a significant imbalance of oxidative stress in placental tissues of TTTS pregnant women,and the decrease in antioxidant activity of placental tissues may be an impor-tant cause of placental perfusion injury.