Objective To explore effects of strengthen pelvic floor muscle training on patients with urinary incontinence after transurethral anatomical enucleation of the prostate (TUAEP).Methods A total of 100 patients with urinary incontinence after TUAEP from October 2014 to March 2016 were randomly divided into control group and intervention group (50 respectively). Patients in control group received normal pelvic floor muscle training. Patients in intervention group received strengthen pelvic floor muscle training. Recovery of patients from urinary incontinence was analyzed using ICI-Q-SF at 1 week, 1 month and 3 months after training. Results Repeated measurement of variance analysis showed that scores of ICIQ and quality of life were significant different before and after the training in both groups (Ftime=832.918,287.139;P<0.05). Differences in scores of ICIQ and quality of life between two groups were statistically significant (Finterval=6.174,20.521;P<0.05). Measurements and interventions were not interacted (Finteraction=0.769,1.590;P>0.05). One month after training, 6 out of 50 cases (12.0%) in intervention group had urinary incontinence, while in control group 14 out of 50 cases (28.0%) had urinary incontinence. Three months after training, all the patients in intervention group recovered from urinary incontinence, while in control group 6 patients (12%) still presented urinary incontinence (P<0.05).Conclusions Strengthen pelvic floor muscle training improves the recovery of urinary incontinence in patients after TUAEP, with better effects than normal pelvic floor muscle training.

Objective: To investigate the effect factors of liver enzymes elevation by monitoring the liver function changes before and after intraportal islet transplantation. Methods: 16 diabetic patients who received intraportal islet transplantation in our hospital were analyzed. The levels of aspartic aminotransferase (AST), alanine aminotransferase (ALT)and total bilirubin (TBil)were monitored after islet transplantation. Results: Among those 16 diabetic patients who received intraportal islet transplantation, 11 patients showed an increased AST and 8 patients showed an increased ALT, among which a 2.5-fold increase in AST was observed in 4 patients and over 1.5-fold elevation of ALT was observed in 3 patients. The level of TBil were in the normal range before and after transplantation in all patients. Transplanted tissue volume of islet was the main factor for significantly increased AST (P<0.05) in this study. It is also shown that the change in portal pressure is related to the AST elevation after islet transplantation. Conclusions The amount of transplanted islet tissue volume is related to the liver enzymes elevation after intraportal islet transplantation. Therefore, the improvement of the purity of islet to reduce the amount of transplanted tissue could be benefit to prevent the liver injury after islet transplantation. Meanwhile, the purified islets should be injected as slowly as possible to maintain a stable portal pressure.

Objective:Previous studies have shown an association between programmed death-ligand 1 expression(PD-L1)in non-small cell lung cancer(NSCLC)and clinical factors and that PD-L1 is positively correlated with TNM staging.This study aimed to explore the prognostic significance of PD-L1 and its correlation with the maximum standardized uptake value(SUVmax).Methods:Clinicopath-ological data and the follow-up information of the 122 de novo primary NSCLC patients were analyzed.PD-L1 expression was detected by immunohistochemistry in this 122 surgically resected non-small cell lung carcinoma tissues.Survival outcomes were analyzed using the Kaplan-Meier method and multivariate Cox proportional hazards model.Correlation between SUVmax and PD-L1 expression was analyzed using Spearman's rank correlation analysis.Results:Multivariate analysis revealed that PD-L1 expression(HR=4.518,95% CI:1.176-17.352,P=0.028)and tumor size(HR=1.404,95%CI:1.020-1.933,P=0.037)were independent risk factors for overall survival(OS) in early NSCLC patients.Sex,age,pathological type,CEA level,and SUVmax group had no obvious effect on OS(P 0.05)in early NSCLC patients.In univariate analyses,sex,pathological type,tumor size,and SUVmax group affected OS in stageⅢ-ⅣNSCLC patients.How-ever,age,CEA level,and PD-L1 expression had no effect on OS.PD-L1 expression was not an independent risk factor for OS in stageⅢ-ⅣNSCLC patients.The SUVmax group had no association with PD-L1 in all patients.Conclusions:PD-L1 expression is an independent risk factor for OS in early NSCLC patients but not in stageⅢ-Ⅳpatients.