OBJECTIVE:To observe the hypoglycemic effects of Huangsang oral solution.METHODS:Diabetes models of mice was induced with alloxan then the mice were randomly divided into the NS group,model control group,phenformin group,and high dose,middle dose and low dose Huangsang oral solution groups(30.0 g?kg-1,15.0 g?kg-1 and 8.0 g?kg-1).The corresponding drugs were given by ig bid for 10 days.Blood glucose was measured with glucose oxidas method.The effects of Huangsang oral solution on blood glucose concentration and glucose tolerance in diabetic mice as well as on blood glucose concentration in the normal mice were observed.RESULTS:The different dose of Huangsang oral solution could decrease the blood glucose level significantly and improve glucose tolerance in alloxan-induced diabetes mice,and the effect was significant compared with the model control group(P