Objective:To translated and Chinesize Craniofacial Pain and Disability Inventory (CF-PDI) and test its reliability and validity in patients with temporomandibular joint disease.Methods:The Spanish version of CF-PDI was translated into Chinese and revised. Using the convenient sampling method, a total of 250 patients with temporomandibular joint disease who were hospitalized in the Second People's Hospital of Foshan from January to December 2019 were selected as research objects. The Chinese version of CF-PDI was used to investigate and the reliability and validity of the questionnaire were verified.Results:In this study, a total of 250 questionnaires were issued and 231 valid questionnaires were collected, with an effective recovery rate of 92.4%. The Chinese version of CF-PDI retained 21 items of the original questionnaire, and the total content validity of the questionnaire was 0.917. Through exploratory factor analysis and principal component analysis, a total of 2 common factors with characteristic roots over or equal to1 can be extracted, the cumulative variance contribution rate was 67.4%, and the loading degree of the factor of each item was 0.486 to 0.744. The Pearson correlation coefficient between the two factors was 0.476, and the Pearson correlation coefficient between factors 1 and 2 and the total questionnaire were 0.785 and 0.814. The differences were statistically significant ( P<0.01) . The correlation coefficient between The Chinese version of CF-PDI and the Pain Digital Rating Scale was 0.496 to 0.532, and he correlation coefficient between The Chinese version of CF-PDI and the total score and scores of each dimension of Pain Catastrophizing Scale was 0.246 to 0.476. The differences were statistically significant ( P< 0.01) . Cronbach's coefficient of the Chinese version of CF-PDI was 0.843, and test-retest reliability was 0.812. Conclusions:Chinese version of CF-PDI has good reliability and validity, which is suitable for pain effect and functional evaluation for patients with temporomandibular joint disease.