BACKGROUNDMatrix metalloproteinase-9 (MMP-9), endostatin (ES) and vascular endothelial growth factor (VEGF) are important angiogenic regulators for many neoplasms. The aim of this study is to judge clinical and prognostic values of detection of serum MMP-9, ES and VEGF in patients with non-small cell lung cancer (NSCLC).

METHODSSerum levels of MMP-9, ES and VEGF were detected in 92 patients with NSCLC, 50 patients with pulmonary benign disease and 52 healthy controls by ELISA method.

RESULTSThe serum levels of MMP-9, ES and VEGF in NSCLC patients were significantly higher than those in patients with pulmonary benign disease and healthy controls (P=0.000, P=0.000, P=0.000). The sensitivity and specificity of serum MMP-9 was 92.51% and 79.10% with a cutoff value of 117.17 μg/L, 88.32% and 74.25% for ES with a cutoff value of 100.31 μg/L, and 83.40% and 75.63% for VEGF with a cutoff value of 380.32 ng/L. Serum MMP-9 and ES levels were significant prognostic factors for lung cancer patients (P=0.0145, P=0.008). The change of serum MMP-9 level after chemotherapy was a useful indicator of prognosis for NSCLC patients (P=0.0322).

CONCLUSIONSThe serum levels of MMP-9, ES and VEGF are significantly increased in patients with NSCLC. They might be used as prognostic parameters in patients with NSCLC.

Objective To observe the clinical effect of endoscope combined with drug therapy in the treatment of hemorrhage of esophageal and gastric varices in patients with cirrhosis ,thus to provide reference for clinical diagnosis and treatment.Methods From January 2017 to January 2018,58 liver cirrhosis patients with ruptured esophageal gastric varices bleeding in Tongji Huangzhou Hospital of Huazhong University of Science and Technology were selected and divided into two groups by random number table method ,with 29 cases in each group.The control group was treated with somatostatin alone.The observation group was treated with somatostatin combined with endoscopic therapy.The clinical efficacy of the two groups was compared ,and the clinical indicators and the changes of indices of TCM syndromes before and after treatment were compared between the two groups .Results The total effective rate of the observation group was 89.8%, which was higher than 79.3% of the control group, and the difference was statistically significant (χ2＝9.75,P＜0.01).After treatment,the pain,abdominal distention,poor appetite,nausea,weakness of the body tired ,depression,boredom,loose stool and other syndromes index scores of two groups were improved obviously ,the improvements in the observation group was better than those in the control group , and the differences were statistically significant (t ＝8.847,9.470,7.833,8.120,9.029,8.120,9.029,all P ＜0.05).After treatment,the white blood cells,platelets of the two groups were increased ,the spleen length to diameter, thickness of spleen,portal venous trunk,spleen vein diameter of the two groups were reduced ,the improvements in the observation group was better than those in the control group , and the differences were statistically significant ( t ＝8.934,8.923,8.933,9.463,9.478,9.463,all P＜0.05).Conclusion Endoscope combined with drugs in the treatment of cirrhotic esophageal variceal hemorrhage has significant clinical efficacy ,and can effectively improve the patients'TCM syndrome score and clinical indicators.