2.Insights on multi-institution practice for physicians of public hospitals
Qiuqi XUE ; Li XIANG ; Lan YAO
Chinese Journal of Hospital Administration 2011;27(3):164-166
A review of the system background for the multi-institution physician practice in China,and an analysis for the specific constraints for physicians of public hospitals to embrace such a practice On this basis, the paper probed into the measures to encourage the physicians for doing so. The measures recommended include advanced design, improvement of the quality of care and safety mechanism,incentives mechanism, mandatory enforcement of medical liability insurance to minimize risk exposure of such a practice, aiming at advancement of this practice.
3.Clinical Observation of Jianpi Shoushen Decoction for Cases of Impaired Glucose Tolerance with Qi Deficiency and Phlegm-dampness Constitution
Xiaoyan ZHOU ; Daijun YAO ; Yaqian LI ; Xue LI
China Pharmacy 1991;0(03):-
OBJECTIVE: To observe the clinical efficacy of Jianpi shoushen decoction in the treatment of cases of impaired glucose tolerance with Qi deficiency and phlegm-dampness constitution. METHODS:62 Patients with impaired glucose tolerance with Qi deficiency and phlegm-dampness constitution were randomized into 2 groups, i.e. trial group were treated with Jianpi shoushen decoction q.d for 3months (p.o.,n=31); control group were treated with 50 mg Acarbose tablet t.i.d for 3 months (p.o.,n=31). Patients in two groups were all received healthy education such as diet guide and sport instruction. The effective rate, glycemic index and weight index of two groups were observed. RESULTS: The rate of hypoglycemic efficacy and weight lose efficacy in trial group were better than in control group(P
4.Ophthalmic imaging features of posterior scleritis
Zhi, LI ; Lin-Li, WANG ; Jun, MEI ; Xue, YAO
International Eye Science 2014;(7):1331-1333
AlM: To analyze, summarize and describe ophthalmic imaging features of posterior scleritis.
METHODS: Clinical data of 16 patients ( 21 eyes ) with posterior scleritis diagnosed in our hospital from October 2008 to June 2013 were retrospectively analyzed. The results of type-B ultrasonic, fundus chromophotograph, fundus fluorescein angiography, CT were recorded for comprehensive evaluation and analysis of ophthalmic imaging features of posterior scleritis.
RESULTS: All patients underwent type-B ultrasonic examination and manifested as diffuse and nodular types. The diffuse type showed diffusely thickened sclera and a dark hypoechoic area that connected with the optic nerve to form a typical “T”-shaped sign. The nodular type showed scleral echogenic nodules and relatively regular internal structure. FFA showed that relatively weak mottled fluorescences were visible in the arterial early phase and strong multiple needle-like fluorescences were visible in the arteriovenous phase, which were then progressively larger and fused; fluorescein was leaked to the subretinal tissue in the late phase;varying degrees of strong fluorescences with less clear or unclear boundaries were visible in the optic disk. CT results showed thickened eyeball wall.
CONCLUSlON: Posterior scleritis is common in young female patients, whose ophthalmic imaging features are varied and more specific in type-B ultrasonic. Selection of rational ophthalmic imaging examination method, combined with clinical manifestations, can accurately diagnose posterior scleritis and avoid the incidence of missed and delayed diagnosis.
5.Study of the common genotype of glucose-6-phosphate dehydrogenase deficiency in newborn infant in Guangdong region
Xue XIAO ; Youxiang ZHANG ; Li YU ; Yao ZHANG
Chinese Journal of Applied Clinical Pediatrics 2014;29(8):616-618
Objective To investigate the genotypic frequency of glucose-6-phosphate dehydrogenase (G6PD) (1376G > T),G6PD 1311C > T and G6PD IVS11-93T > C in 50 newborns with G6PD deficiency in Guangdong region.Methods To identify G6PD deficiency in the patients of neonatal ward in Guangzhou First People's Hospital during 2010,detected by methemoglobin reduction test and measurement of G6PD/6-phosphate dehydrogenase (6PGD) ratio.Fifty G6PD deficiency subjects were classified into the experimental group,20 neonatal jaundice subjects were classified into the control group.Genomic DNA was extracted by standard method from the peripheral blood of each subject.PCR-direct DNA sequence analysis was used to identify G6PD 1376G > T,1311C > T and 11 intron 93T > C mutations.Results The overall results of mutation analysis in the 50 G6PD deficiency subjects showed the existence of 3 different alleles:G6PD 1376G >T,1311C >T,11 intron 93T > C(including 1311C > T/IVS11-93T > C and 1376G >T/1311C >T/IVS11-93T > C complex mutations).The different genotypic frequency in the experimental group was G6PD 1376G >T 26.0% (13/50 cases),1311C > T 4.0% (2/50 cases),11 intron 93T > C 4.0% (2/50 cases),1311C > T/IVS11-93T > C 2.0% (1/50 cases),1376G > T/1311C > T/IVS11-93T > C 2.0% (1/50 cases).The G6PD enzyme activity of the subjects with 1311C > T/IVS11-93T > C and 1376G > T/1311C > T/IVS11-93T > C complex mutation were reduced.These G6PD mutations were not found in the controls.Conclusions G6PD 1376G > T is one of the commonest mutation in G6PD deficiency newborn in Guangdong region.A novel complex mutation 1376G > T/1311C > T/IVS11-93T > C in this study was found.
6.The role and clinical significance of follicular helper T cells and interleukin-21, CXCL13 in patients with ankylosing spondylitis
Linhu YAO ; Jinghong MENG ; Xue LI ; Ping WEI
Chinese Journal of Rheumatology 2014;18(8):552-554
Objective To test the level of follicular helper T cells (Tfh) and interleukin (IL)-21,CXCL13 in the peripheral blood of patients with ankylosing spondylitis (AS),and to analyze the relationship between Tfh and clinic features and explore the possible immunological pathogenesis of AS.Methods The Tfh cells were obtained from patients and normal controls and detected by flow cytometry.While the levels of IL-21,CXCL13 in patients and normal controls were measured by enzyme-linked immunosorbent assay (ELISA) tests.Data analysis were performed by Student's t-test,Rank-sum test,Spearman's correlation test.Results The expression of CD4+CXCR5 qCOS + cells (Tfh) (mean rank 33.71) and IL-21 [(299±27) ng/L],CXCL13 [(5.8±1.0) μg/L] in the peripheral blood of AS was significantly higher than normal controls [mean rank 23.54,(176±26) ng/L,(4.2±0.8) μg/L] (Z=-2.258,t=17.221,t=6.464,all P<0.05).It was similar in AS with peripheral joint involvement compared with AS of non-peripheral joint involvement,and there was no difference between AS patients with positive HLA-B27 and those without HLA-B27.Mean -while,no correlation was found between the expression of Tfh,IL-21,CXCL13 and level of ESR,CRP,BASDAI.And there was no significant correlation between the expression of Tfh and IL-21,CXCL13 (P>0.05).Conclusion The expression of Tfh and the levels of IL-21,CXCL13 are increased significantly,but are not closely relatedto disease activity.These results indicate that the abnormality of Tfh may play an important role in the pathogenesis of AS.
9.The Analysis of Spinal Tuberculosis by Imaging
Yingang ZHANG ; Ning JIAO ; Jing LI ; Anjin YAO ; Jinshan XUE
Journal of Practical Radiology 2001;0(01):-
Objective To determine the potential value of imaging for spinal tuberculosis. Methods 180 patients proved as spinal tuberculosis by operation or clinical follow who underwent X-ray film, CT and MRI were reviewed. They were classified A, B or C in term of imaging and clinical symptom. A was the normal of X- ray film and positive of CT or MRI. B was positive of X-ray film, CT and MRI. C was with the neurological symptoms. Results 40 patients ( 40/180 ) were categorized as A . They had short duration (
10.THE COMPARISON OF THREE KINDS OF ENZYMELINKED IMMUNOSORBENT ASSAY ON SCREENING THE “LEAKY” PHENOTYPE SCID MICE
Yi LI ; Heng CUI ; Xue YE ; Yu YAO
Acta Anatomica Sinica 1953;0(01):-
Objective Choose an easy method to screen the “leaky" phenotype SCID mice before experimental use. Methods IgG in SCID mice serum was assayed by three kinds of ELISA(sandwich ELISA, sandwich indirect ELISA and Avidin\|biotin sandwich ELISA). Results Avidin\|biotin sandwich ELISA is the most sensitive method of the three, and 41 SCID mice of 6~8 weeks old were assayed with this method. The average IgG of 40 SCID mice was 0 24?0 16mg/L, only one was 2\^3mg/L. The “Leaky" probability was 2\^4%.Conclusion\ The Avidin\|Biotin sandwich ELISA is an easy, sensitive and reliable method to screen“leaky" SCID mice.\;[