1.Fixation of displaced proximal humeral fractures with proximal humeral internal locking plate in the elderly
Quan JI ; Liangyuan WEN ; Qingyun XUE ; Lilian ZHAO ; Gongyi HUANG
Chinese Journal of Geriatrics 2011;30(9):749-752
Objective To investigate the treatment effect of the proximal humeral internal locking system (PHIL()S) on the elderly patients with displaced proximal humeral fractures.MethodsFrom Feb 2004 to Mar 2007, 36 patients (mean age: 72.2 years) with proximal humeral fractures were treated with PHILOS plate fixation which included 14 cases with 2-part, 17 cases with three-part and 5 cases with four-part fractures according to Neer classification.Operation time,intraoperative blood loss, blood transfusion, perioperative complications and function evaluation of the operated shoulder joint were calculated with 14.5 months follow-up at average.Results The average operation time and blood loss were (61.5± 11.6) min and ( 165.2±91.2) ml, respectively. 1 case with accidents of blood vessel and 1 case with pneumonia were found without neurovascular injuries. All fractures were radiographically healed in an average of 3-5 months.No necrosis of humeral head appeared and 30 (83.3%) cases were excellent or good according to Neer scoring system. Two part fracture and early operation ( within 3 days after operation) might improve the postoperative function of shoulder joint, but the patient's age, gender and ASA score were not statistically with Neer score.Conclusions PHILOS plate fixation is a suitable procedure for displaced proximal humeral fractures via stable fixation and early rehabilitation, especially for elderly patients combined with osteoporosis.
2.The accuracy and safety of CT guided cutting needle biopsy for the hepatic lesions near the diaphragmatic dome
En-Quan ZHANG ; Wei CHEN ; Ming LU ; Jian WANG ; Ping CAI ; Xue-Quan HUANG ;
Journal of Interventional Radiology 2006;0(12):-
Objective To evaluate the safety and accuracy of CT-guided cutting needle biopsy for the hepatic lesions near diaphragmatic dome.Methods A total of 25 cases with hepatic lesions near the diaphragmatic dome were undertaken CT-guided cutting needle biopsy using 16 gauge or 18 gauge core biopsy needles.Results Histological examination showed malignancy in 17 cases and benign in 8 with 2 false negative results(8%),and there were no false positive results.The specificities of malignant and benign lesions were 100% and 75%,respectively.Overall accuracy was 92%.Pneumothorax,needle tract hemorrhage,and subcapsular hepatic hemorrhage occurred in 2(8%),1(4%)and 1(4%),respectively.Conclusion CT-guided cutting needle biopsy for the hepatic lesions near diaphragmatic dome is a reliable and relatively safe diagnostic method.(J Intervent Radiol,2007,16:838-840)
3.CT-guided permanent ~(125)I seed brachytherapy for vertebral metastatic cancer
Xue-Quan HUANG ; Ping CAI ; Lin ZHANG ; Wei CHEN ; Jie-Hui ZHU ; En-Quan ZHANG ; Jian WANG ;
Journal of Interventional Radiology 2006;0(12):-
Objective To evaluate the functional outcome,predicting response and toxicity of CT- guided permanent implanted ~(125)I seed branchytherapy for metastatic cancers in vertebrae.Methods Forty three vertebrae with metastatic cancer were treated by CT-guided percutaneous permanent implanted ~(125)I seed branchytherapy in 15 patients.There were 8 male and 7 female patients with average age of 54.6 years and 2 to 5 vertebrae involved in this group.According to the size of tumor,the optimal activity and quantity of seeds were calculated by TPS and correlative formula.~(125)I seeds were implanted percutaneous puncture under CT- guidance with coaxial needles to pass the normal osseous tissue for approaching the lesions including 3 routes of pedicnlar lateral and anterior ways.The distance between seeds and posterior border of vertebral body was over 3 nun(3-10mm).Permanent ~(125)I seed implantation brachytherapy for paraspinal metastatic lesions were also taken place.Results Mean follow-up time was 12.3 months(range 3-30 months)and outcome was evaluated clinically and radiographieally in 10 of 15 procedures,with 5 only on clinical data.No new pain occurred at 11 sites with no previous complaint.The pain was completely controlled at 18/32 sites,partial control at 14/32 sites.No complications correlated to the radiotherapy damage of nerve and spinal cord were found.Conclusion The procedure of CT-guided permanent implanted ~(125)I seeds brachytherapy for vertebral metastatic cancers is a safe effective and minimal invasive method with few complications.It is beneficial not only for pretherapeutic metastasis but also for recurrent tumors after radiotherapy;bearing rather high tolerance and safety.(J Intervent Radiol,2007,16:834-837)
4.Construction and Characterization of a ppbR gene Mutant of Pseudomonas sp. M18
Fei ZHENG ; Xian-Qing HUANG ; Yu-Quan XU ; Xue-Hong ZHANG ;
Microbiology 1992;0(02):-
Pseudomonas sp. M18, one of plant-growth-promoting rhizobacteria, can produce secondary metabolites including phenazine-1-carboxylic acid (PCA) and pyoluteorin (Plt). PA2572 gene coding protein is a probable two-component response regulator in Pseudomonas according to homologous speculations. In order to investigate its genetic function, PA2572 homologous gene, ppbR, was amplified from M18 genome, inactivated by inserting a Gm cassette. The resulting reconstruct was introduced into the M18 genome using homologous recombination technique, so as to obtain the null mutant M18P. The results showed that the M18P has less flagellar swimming and swarming motility, and yielded fewer PCA. The production of PCA was only 50% of the wild type. However, there was no remarkable difference between mutant and wild type in producing pyoluteorin in KMB medium.
6.Progress of potential therapeutic targets and small molecule ligands of anti-colorectal cancer pathogenic Fusobacterium nucleatum
Xue-xin BAI ; Ya-hui HUANG ; Chun-quan SHENG ; Shan-chao WU
Acta Pharmaceutica Sinica 2023;57(3):639-645
The composition of intestinal microflora is closely related to the occurrence and development of colorectal cancer (CRC). Among them,
7.Two new triterpenes from Maytenus guangxiensis with their antiproliferative activity
Yuan-yuan HUANG ; Xue-gong JIA ; Fu-sheng DENG ; Jing-ya MO ; Jing-quan YUAN
Acta Pharmaceutica Sinica 2022;57(2):441-445
Four triterpenoids were isolated and purified from the 95% ethanol extract of
8.Experimental study of the inhibitory effects of biotic royal jelly on the growth of ascitic hepatoma cell H22 in mice
Yong-Zi WANG ; Chang-Quan LING ; Xue-Qiang HUANG ; Pin-Rong PAN
Academic Journal of Second Military Medical University 2001;22(4):357-359
Objective: To observe the inhibitory effects of biotic royal jelly on the ascitic hepatoma cell H22. Methods: Mice bearing H22 tumor were fed on different types of royal jelly: No.1, 2 and 3. Their anti-tumor effects were observed in vivo. The general royal jelly and normal saline were observed as control. Results: Among these biotic royal jelly, the biotic royal jelly No.1 showed obvious tumor-inhibiting and survival-prolonging effects. In addition, it increased the number of WBC and augmented the amount of IL-2 and IFN-γ; the pathological study also indicated the denaturing and necrosis of most tumor cells with nuclei constraining and cell membrane rupturing, and large amount of lymphocytes and plasmacytes infiltrating around the mass. Conclusion: The No.1 biotic royal jelly has obvious anti-tumor effect, and it may take effects by inhibiting or killing tumor cells and improving the immunity of the host.
9.Recognition of Gaussian pixelate Chinese character based on simulated prosthetic vision.
Ji ZHAO ; Xue-Quan LV ; Chun-Rui HUANG ; Pan-Pan CHEN ; Xin-Yu CHAI
Chinese Journal of Medical Instrumentation 2009;33(5):317-319
In this paper, Gaussian pixelate Chinese character processing software is designed, and HMD is used to realize the recognition experiment for pixelate Chinese characters based on simulated prosthetic vision. The structure of recognition system, software design and the experiment for determining Gaussian width (sigma) are presented. It is shown that when sigma is 0.235, the recognition program is the best.
Equipment Design
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Image Processing, Computer-Assisted
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Language
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Prostheses and Implants
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Software Design
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Visual Perception
10.Implementation of eye movement tracking system based on camshift algorithm.
Chun-Rui HUANG ; Xue-Quan LV ; Ji ZHAO ; Qiu-Shi REN ; Xin-Yu CHAI
Chinese Journal of Medical Instrumentation 2009;33(4):239-242
In this article, the implementation of eye movement tracking system includes three procedures: hardware acquisition, data extraction and overall analysis. The system is based on Camshift algorithm with an eye tracking module added, developed on VC++ 6.0. The system can track the eye movement effectively in simulated phosphene evaluation experiment based on prosthetic vision.
Algorithms
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Analysis of Variance
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Eye Movements
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physiology
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Prosthesis Design