1.Operating rules of cotton-pave moxibustion and its samples for clinical application in dermatopathy.
Xue-wei LI ; Jia ZUO ; Wei-ling HUANG ; Yun-kuan YANG
Chinese Acupuncture & Moxibustion 2010;30(3):218-220
In clinical researches, the authors find that cotton-pave moxibustion has obvious effect for treatment of common dermatopathy, such as herpes zoster. This therapy has some advantages such as easy operation, obvious clinical effect, slight and short burning pain and easy to be accepted by patients. The purpose of this paper is to make the operation of cotton-pave moxibustion standardized, spread and popularize the application of this therapy in dermatopathy through detailed description to the operation method and points for attention of cotton-pave moxibustion and its typical cases.
Humans
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Male
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Middle Aged
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Moxibustion
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methods
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Skin Diseases
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therapy
2.Topic model for Chinese medicine diagnosis and prescription regularities analysis: case on diabetes.
Xiao-Ping ZHANG ; Xue-Zhong ZHOU ; Hou-Kuan HUANG ; Qi FENG ; Shi-Bo CHEN ; Bao-Yan LIU
Chinese journal of integrative medicine 2011;17(4):307-313
Induction of common knowledge or regularities from large-scale clinical data is a vital task for Chinese medicine (CM). In this paper, we propose a data mining method, called the Symptom-Herb-Diagnosis topic (SHDT) model, to automatically extract the common relationships among symptoms, herb combinations and diagnoses from large-scale CM clinical data. The SHDT model is one of the multi-relational extensions of the latent topic model, which can acquire topic structure from discrete corpora (such as document collection) by capturing the semantic relations among words. We applied the SHDT model to discover the common CM diagnosis and treatment knowledge for type 2 diabetes mellitus (T2DM) using 3 238 inpatient cases. We obtained meaningful diagnosis and treatment topics (clusters) from the data, which clinically indicated some important medical groups corresponding to comorbidity diseases (e.g., heart disease and diabetic kidney diseases in T2DM inpatients). The results show that manifestation sub-categories actually exist in T2DM patients that need specific, individualised CM therapies. Furthermore, the results demonstrate that this method is helpful for generating CM clinical guidelines for T2DM based on structured collected clinical data.
Diabetes Mellitus, Type 2
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diagnosis
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therapy
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Diagnosis, Differential
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Humans
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Medicine, Chinese Traditional
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Models, Theoretical
3.The point of view of moxibustion in the book, A General Survey of Moxibustion.
Lian-Shi ZHUO ; Li ZHOU ; Shan WANG ; Xue-Kuan HUANG
Chinese Acupuncture & Moxibustion 2005;25(1):72-74
OBJECTIVETo study on academic point of view of the book, A General Survey of Moribustion.
METHODSStudy academic thought of the book and clarify academic origin and characteristics of the book.
CONCLUSIONProcessing of argyi leaf, manufacture of mugwort floss and size of moxa cone have a certain technique standards in the book. The book indicates that small cones should be used with more times of moxibustion. and the properties of mugwort floss are not dry and heat, but are warm and moist and mild, moxibustion not only can be used to treat cold syndrome but also can be used to treat heat syndrome; the body can response to the external moxibustion. The above points of view have still guiding significance in nowadays.
Acupuncture Points ; Acupuncture Therapy ; Artemisia ; Books ; Humans ; Moxibustion ; Surveys and Questionnaires
4.Effects of electro-acupuncture on expression of triggering receptor expressed on myeloid cells 1 in ankle joint synovial tissue of acute gouty arthritis rats.
Chao-Nan ZHANG ; Xue-Kuan HUANG ; Yan LUO ; Juan JIANG ; Lei WAN ; Ling WANG
Journal of Southern Medical University 2015;35(1):133-136
OBJECTIVETo investigate the effects of electro-acupuncture (EA) on the expression of triggering receptor expressed on myeloid cell (TREM)l in ankle joint synovial tissue of acute gouty arthritis (AGA) rats.
METHODSForty male SD rats were randomly divided into 4 groups: normal, AGA, medication and EA group, 10 rats in each group. AGA model was established by induced monosodium urate (MSU) method, except the normal group. Tow days before AGA model was established, normal and AGA groups were lavaged with normal saline (20 ml/kg), medication group was lavaged with colchicine solution (20 ml/kg), EA(1.5-2 Hz, D.-D.wave, 9v; 1-3 rnA) was applied to "Sanyinjiao" (SP6), "jiexi" (ST41) and "Kunlun" (BL60) for 20 min, once daily;continuously for 9 days. Then observed the changes in dysfunction, and the content of TNF-α and IL-lβ detected by ELISA, the expression of TREM-l detected by immunohistochemistry and western blot.
RESULTSCompared to the normal group, the AGA group of the dysfunction index increased significantly (P<0.01), the content of TNF-α and IL-lβ increased significantly (P<0.05), the expression of TREM-l in synovial tissue increased significantly (P<0.05); the medication and EA groups compared to the AGA group, the dysfunction index decreased significantly (P<0.01), the content of TNF-α and IL-lβ decreased significantly (P<0.05), the expression of TREM-l in synovial tissue decreased significantly (P<0.05); there were not statistically significant between the medication and EA group (P>0.05).
CONCLUSIONEA treating AGA may be through down-regulating the expression of TREM -1 in synovial tissue.
Animals ; Ankle Joint ; metabolism ; pathology ; Arthritis, Gouty ; metabolism ; therapy ; Electroacupuncture ; Interleukin-1beta ; metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; Receptors, Immunologic ; metabolism ; Synovial Membrane ; metabolism ; Triggering Receptor Expressed on Myeloid Cells-1 ; Tumor Necrosis Factor-alpha ; metabolism
5.The feasibility and safety of radiofrequency ablation for secondary splenomegaly and hypersplenism in dogs.
Quan-da LIU ; Kuan-sheng MA ; Zhen-ping HE ; Jun DING ; Xue-quan HUANG ; Jia-hong DONG
Chinese Journal of Surgery 2003;41(4):299-302
OBJECTIVETo assess the feasibility and safety of radiofrequency ablation (RFA) in spleen to treat secondary splenomegaly and hypersplenism in dogs.
METHODSFourteen healthy mongrel dogs were randomly divided into two groups: group A (n = 4) and group B (n = 10) Both groups underwent ligation of the splenic vein and its collateral branches to induce congestive splenomegaly. At the end of the 3rd week, radiofrequency thermal ablation of the spleen was performed in the group B via laparotomy. After splenic RFA, the procedure-related complications were observed, CT scan was performed and the spleens were obtained according to schedule. The radiofrequency (RF) thermal lesions and its histo- pathological changes of the spleen were examined regularly.
RESULTSThere were no morbidity and mortality in the experimental dogs. CT findings revealed that splenomegaly could sustained over 2 months after ligation of the splenic vein. The segmental RF lesions included hyperintense zone of coagulative necrosis and more extensively peripheral hypo-intense infarcted zone. The latter was called as "bystander effect". The infarcted zone would be absorbed and subsequently disappeared between 4 and 6 weeks after RFA, and the size of the remnant spleen shrunk, but the lesion of coagulative necrosis hardly altered. The fundamental histopathological changes of splenic lesions caused by RF thermal energy included local coagulative necrosis and the peripheral thrombotic infarction zone. Subsequently, tissue absorption and fibrosis occurred in the zone of thrombotic infarction. Simultaneously occluded vessels, fibrin deposition, and disappearance of normal splenic sinuses resulted in the condensed structure of the viable remnant spleen, which were the pathological basis responsible for the shrunk spleen.
CONCLUSIONSIt is feasible and safe to perform RFA in the spleen to treat experimental splenomegaly and hypersplenism. The RFA technique could be safely performed clinically via laparotomy or laparoscopic procedure to strictly isolate the spleen from the surrounding organs.
Animals ; Catheter Ablation ; Disease Models, Animal ; Dogs ; Feasibility Studies ; Female ; Hypersplenism ; etiology ; pathology ; surgery ; Ligation ; adverse effects ; Male ; Random Allocation ; Spleen ; diagnostic imaging ; pathology ; Splenectomy ; methods ; Splenic Vein ; surgery ; Splenomegaly ; etiology ; pathology ; surgery ; Tomography, X-Ray Computed
6.Effect of Fushengong Prescription on p38 MAPK Signal Pathway of Rats with Chronic Renal Failure
Pan TONG ; Xue-kuan HUANG ; Qing SHEN ; Yang ZHANG ; Ke XU ; Hong-yu LUO
Chinese Journal of Experimental Traditional Medical Formulae 2020;26(14):105-110
Objective:To observe the effects of Fushengong prescription on p38 mitogen-activated protein kinase(p38 MAPK) signal pathway of rats with chronic renal failure(CRF),and to explore its mechanism of reducing inflammatory reaction of renal tissues and delaying the progress of renal interstitial fibrosis. Method:The 55 male Sprague-Dawley rats were randomly divided into normal group,model group, and low,medium and high dose groups of Fushengong prescription,with 11 rats in each group.The normal group was routinely reared, and the other four groups of rats were fed a diet containing 0.5% adenine to produce a model of CRF, which was continuously molded for 21 days.After successful modeling,all rats switched to conventional feed.Normal group and model group were given normal saline 20 mL·kg-1,and each group of Fushengong prescription was given 4,8,16 g·kg-1 of water prescription once a day for 30 days.After the experiment,Masson staining was used to observe the degree of renal interstitial fibrosis.The expression of monocyte chemotactic protein-1(MCP-1) in renal tissues was detected by immunohistochemistry. The expression of phosphorylated p38 mitogen-activated protein kinase(p-p38 MAPK) and transformed growth factor-
7.Effect of Fushengong Prescreption on Regulation-antagonism Effect of ACE-AngⅡ-AT1R Axis and ACE2-Ang(1-7)-MASR Axis of Rats with Chronic Renal Failure
Ke XU ; Xue-kuan HUANG ; Qing SHEN ; Yang ZHANG ; Hong-yu LUO ; Jia-yu TIAN ; Bo ZOU ; Qin YANG ; Ke-ming HOU
Chinese Journal of Experimental Traditional Medical Formulae 2021;27(5):62-69
Objective:To study the effect of Fushengong prescreption on the regulation-antagonism effect of angiotensin converting enzyme-angiotensin Ⅱ-angiotensin Ⅱ 1 receptor (ACE-AngⅡ-AT1R) axis and angiotensin converting enzyme 2-angiotensin (1-7)-Mas receptor[ACE2-Ang(1-7)-MASR] axis of rats with chronic renal failure(CRF), and to explore its mechanism of delaying the development of CRF. Method:The 65 male SD rats were randomly divided into normal group (
8.Effect of Fushengong Prescription on Wnt/β-catenin Signaling Pathway in Kidney of Rats with Chronic Renal Failure
Yang ZHANG ; Xue-kuan HUANG ; Qing SHEN ; Pan TONG ; Ke XU ; Hong-yu LUO ; Jia-yu TIAN ; Bo ZOU ; Shi YIN
Chinese Journal of Experimental Traditional Medical Formulae 2020;26(24):89-95
Objective:To observe the effects of Fushengong prescription on secretory glycoprotein (Wnt)/