Medical molecular imaging not only promotes the development of medical imaging, but also pushes research progress of life science and benefits the amalgamation of multi-subjects in medical imaging. This editorial overviews the history and development trends of medical molecular imaging.
Humans ; Molecular Imaging ; trends

Cancer has become the leading cause of mortality in the urban area of China. Whole body diffusion weighted imaging (WB-DWI), also known as virtual positron emission tomography, has gradually become accepted as an image tool in tumor localization, characterization, staging and monitoring response to therapy or tumor recurrence. Our article aimed to summarize the limited initial clinical use of WB-DWI in the referred area, and to analyze the most potential advantage of WB-DWI in therapeutic monitoring and tumor staging. WB-DWI as a highly sensitive, completely non-invasive, well-tolerated and low price technique has a promising furture in tumor assessment. Profound clinical study is necessary for its further application improvement.
China ; Diffusion Magnetic Resonance Imaging ; methods ; Humans ; Neoplasm Staging ; Neoplasms ; diagnosis ; pathology ; Whole Body Imaging ; methods

Objective Depending on the stratification of risk factors, to observe the efficacy and safety of different doses of atorvastatin in patients of northern Han population with acute ischemic cerebrovascular disease. Methods One hundred and sixty patients with acute ischemic cerebrovascular disease, admitted from Oct. 2013 to Jan. 2014, were involved in present study, and they were divided into three groups according to the etiology and pathogenesis. In addition to routine treatment, three groups of patients were given 20mg (n=50), 40mg (n=50) and 60mg (n=60) atorvastatin, respectively. Lipids contents, liver function, renal function, muscle enzymes, high sensitivity C reactive protein (hCRP) levels, and NIH Stroke scale (NIHSS) score were determined respectively before treatment and before discharge from the hospital. Results Blood lipid levels were reduced in all the 3 groups, total cholesterol (TC), high density lipoprotein cholesterol-C (HDL-C) and low density lipoprotein cholesterol-C (LDL-C) lowered obviously with significant difference among the 3 groups (P<0.05); while the triglyceride (TG) level showed less lowering, and no statistical difference was found among groups (P>0.05). The highest compliance rate of LDL-C was observed in 60mg group. Compared with those before treatment, the mean levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were elevated, and that of total bilirubin (TBil) and direct bilirubin (DBil) declined after treatment (P<0.05). The levels of blood urea nitrogen (BUN) and creatinine (Cr) were lowered, while that of glomerular filtration rate (GFR) increased compared with those before treatment, but there was no significant difference among groups (P>0.05). The average level of creatine kinase (CK) was lowered (P<0.05), while that of creatine kinase-MB (CK-MB) became higher (P<0.01) after treatment as compared with that before treatment. After treatment, the level of hypersensitive C-reactive protein (hCRP) declined in 20mg and 40mg group, and increased in 60mg group, but the changes showed no significant difference among the 3 groups (P>0.05). NIHSS scores were decreased in a dose-dependent manner after treatment with no significant difference among the 3 groups (P=0.157). Conclusions Atorvastatin can safely and effectively reduce the blood lipid levels, improve the neurological deficits, and reduce the hCRP level to certain extent. Administration of 60mg of atorvastatin may result in highest compliance rate of LDL-C and the greatest degree of improvement of NIHSS. However, further study should be untaken to demonstrate if the long-term and high-dose medication of atorvastatin is safe and effective for ischemic stroke.

Adult ; Diagnosis, Differential ; Female ; Granulomatous Disease, Chronic ; metabolism ; pathology ; Hodgkin Disease ; metabolism ; pathology ; Humans ; Ki-1 Antigen ; metabolism ; Lewis X Antigen ; metabolism ; Lymphoma, Large B-Cell, Diffuse ; metabolism ; pathology ; Lymphoma, Large-Cell, Anaplastic ; metabolism ; pathology ; Young Adult

A microfluidic chip with micropillar arrays for three-dimensional (3D) cell culture was designed and validated.The chip consisted of a polydimethylsiloxane (PDMS) channel plate and a glass cover plate.One cell culture chamber composed of two rows of micropillar arrays and two lateral channels for transporting the culture medium were integrated on the PDMS channel plate.The spacing between micropillars directly affects the chip performance, which is critical for the design of the chip.In this work, the spacing between micropillars was optimized by numerical simulation and experimental validation.With the optimized microfluidic chip, the mixture of cells and extracellular matrix mimics could be steadily injected into the cell culture chamber, the nutrients in the culture medium from the lateral channels could quickly diffuse into the chamber, and the cell metabolites could also timely diffuse out of the chamber.To test the stability of the microenvironment in the microfluidic chip, neural stem cells were three-dimensionally cultured.

Adult ; Antigens, CD20 ; metabolism ; CD3 Complex ; metabolism ; Diagnosis, Differential ; Facial Dermatoses ; metabolism ; pathology ; surgery ; Follow-Up Studies ; Humans ; Lymphoma, B-Cell, Marginal Zone ; metabolism ; pathology ; Lymphoma, Large-Cell, Anaplastic ; metabolism ; pathology ; Male ; Pseudolymphoma ; metabolism ; pathology ; surgery ; Skin Neoplasms ; metabolism ; pathology

Actins ; metabolism ; Adult ; Diagnosis, Differential ; Granzymes ; metabolism ; Histiocytic Sarcoma ; metabolism ; pathology ; Humans ; Ki-1 Antigen ; metabolism ; Lymph Nodes ; metabolism ; pathology ; Lymphoma, Large-Cell, Anaplastic ; metabolism ; pathology ; Male ; Neoplasms, Muscle Tissue ; metabolism ; pathology ; Protein-Tyrosine Kinases ; metabolism ; Receptor Protein-Tyrosine Kinases

Chromosomes, Human, Pair 22 ; Humans ; Infant, Newborn ; Male ; Trisomy

Adult ; Antigens, CD20 ; metabolism ; Burkitt Lymphoma ; metabolism ; pathology ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Histiocytic Necrotizing Lymphadenitis ; metabolism ; pathology ; Humans ; Lymphatic Diseases ; metabolism ; pathology ; Lymphoma, Large B-Cell, Diffuse ; metabolism ; pathology ; Lymphoma, Large-Cell, Anaplastic ; metabolism ; pathology ; Neprilysin ; metabolism ; Proto-Oncogene Proteins c-bcl-6 ; metabolism ; Receptors, Complement 3d ; metabolism ; Submandibular Gland Diseases ; metabolism ; pathology ; Young Adult

Tilianin was separated and authenticated from the seeds of Dracocephalum moldavia, a Uygur medicine, by chromatographic technique and spectroscopic method. The purity of tilianin is more than 98% determined by HPLC area normalization method. Thin layer chromatography (TLC) method was used to separate tilianin from D. moldavia by mixture of chloroform-methanol (5: 1) as a developing solvent on high performance silicagel precoated plate (SGF254) and using aluminium trichloride as a chromogenic agent for qualitative identification of D. moldavia. To establish a HPLC method for quantitative analysis of D. moldavia, tilianin was used as a Quantitative marker and separated on a C18 (4.6 mm x 250 mm, 5 μm) column with acetonitrile-01% formic acid (25: 75) as the mobile phase and detected at 330 nm. The calibration curve of tilianin displayed ideal linearity over the range of 0.617 2-123.44 μg x mL(-1) with a regression equation of Y = 33.773X - 0.824 8 (r = 1). The average recovery of tilianin was 101.0% with RSD of 3.7%. The RSD values of intra-day and inter-day precision were less than 2%. The content of tilianin in 4 batches of the authenticated semen of D. Moldavia was between 0.016 and 0.187 mg x g(-1). The qualitative and quantitative method established is suitable for the quality evaluation and assessment of semen of D. Moldavia.
Chromatography, High Pressure Liquid ; Chromatography, Thin Layer ; Drugs, Chinese Herbal ; chemistry ; isolation & purification ; standards ; Flavonoids ; chemistry ; isolation & purification ; standards ; Glycosides ; chemistry ; isolation & purification ; standards ; Lamiaceae ; chemistry ; Magnetic Resonance Spectroscopy ; Quality Control