Retinal ischemia-reperfusion injury (RIRI) is a common pathological and physiological clinical oculopathy,which can occur in retinal artery and vein occlusion,diabetic retinopathy and acute angle-closure glaucoma.The resulting ischemia can cause cell metabolic dysfunction,serious retinal damage and descending visual function.RIRI is the result of multiple factors.The currently accepted hypotheses mainly include the injury effect of oxygen-derived free radicals,intracellular calcium overload,the action of leucocyte and apoptosis.However the protection and treatment research in the RIRI is limited.The present paper reviews the progression in the drug intervention of RIRI.

Fatigue is one of the most common complaints in cancer patients that profoundly affects all aspects of quality of life.However,cancer-related fatigue remains under recognized and poorly treated.This rcview has been conducted with the causes and potential treatments of fatigue in cancer patients.The methods for evaluating fatigue,and possible therapeutic options are also discussed.

Children with plastic bronchitis,characterized by unknown origin,insidious onset,rapid progress,severe symptom and high mortality,is a relatively rare disease.Also,it is difficult to diagnose and treat with plastic bronchitis characterized by marked airway obstruction,via the formation of large gelatinous or rigid airway cast.It is associated with certain diseases including bronchial asthma,cystic fibrosis,accompanied with acute chest syndrome with sickle cell disease,congenital heart disease and bacterial and viral respiratory infection.Clinicians should be aware of this disease,and early bronchoscopy should be intervened.

Cariostatic Agents ; therapeutic use ; China ; Dental Caries ; prevention & control ; Fluorides ; therapeutic use ; Health Promotion ; Humans ; Oral Health

Acupuncture Therapy ; Adult ; Hoarseness ; therapy ; Humans ; Hysteria ; therapy ; Male

The study aims to observe the clinical efficacy of Baoerkang san on spleen-deficiency and dampness-obstructing diarrhea in children. Children diarrhea divided into acute diarrhea (group I) and chronic persistent diarrhea (group II). A randomized, double-blind, positive control test was conducted for dose finding. The 340 cases with acute diarrhea in group I were divided into three groups: the high dose group (112 patients), the low dose group (113 patients) and the positive control group (115 patients), which were treated for 3 days. Their clinical efficacies were compared to evaluate the clinical safety of Baoerkang san. The 167 patients with chronic persistent diarrhea in group If were divided into the high dose group (56 patients), the low dose group (55 patients) and the control group (56 patients), which were treated for 5 days. Their clinical efficacy were compared to evaluate the clinical safety of Baoerkang san. According to the results, the cure rate and the effective rate of acute diarrhea and chronic persistent diarrhea in the high dose group and the low dose group were significantly higher than that of the positive control group (P <0. 05, P < 0.01). In the treatment of spleen-deficiency and dampness-obstructing diarrhea with traditional Chinese medicines, the cure rate and the effective rate of acute diarrhea and chronic persistent diarrhea in the high dose group and the low dose group were significantly higher than that of the positive control group (P < 0.05, P < 0.01). During the test, all of the three groups did not suffer any adverse event, with no any abnormality in general physical indexes. In conclusion, Baoerkang san shows a significant efficacy in treating acute diarrhea and chronic persistent diarrhea (spleen-deficiency and dampness-obstructing) and safe clinical application.
Child ; Child, Preschool ; Diarrhea ; drug therapy ; physiopathology ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Humans ; Infant ; Male ; Phytotherapy ; Spleen ; drug effects ; physiopathology ; Treatment Outcome

Dermatovenereology have developed rapidly in fields including genodermatology, dermatological epidemiology, skin immunology, infectious skin diseases, clinical diagnosis, drug treatment, light therapy, and sexually transmitted diseases in recent years. Meanwhile, many skin diseases and a few venereal diseases still lack effective ways of treatment and control. More efforts should be made in both basic and clinical researches in the related fields.
Dermatology ; trends ; Forecasting ; Humans ; Venereology ; trends

AIM: Integrins act as receptors for molecules of the extracellular matrix (ECM) and play a major role in mediating cell morphology change,metabolism,function,migration,proliferation and differentiation. It is still unclear that whether ECM is associated with regulation of microglial activation and integrin expression. The study investigated the effects of three different ECM (fibronectin, vitronectin and laminin) on the expression of rat microglia integrin. METHODS:Experiments were performed in Research Center for Clinical Neurology, Tongji Medical College of Huazhong University of Science and Technology from May 2006 to August 2007. ①Neonatal Wistar rats were bought from Experimental Animal Center of Tongji Medical College. Animal intervention met the animal ethical standard. ②Rat microglia was cultured and purified. Culture plate was coated with fibronectin, vitronectin and laminin, and non-ECM served as control. ③The influence of individual ECM on microglia integrin expression and microglia surface expression of MHC Ⅰ by flow cytometry. RESULTS:①MHC classⅠexpression on rat microglia was significantly increased by fibronectin and vitronectin(P

The pathogenic basis of degenerative retinal diseases is structural and functional abnormality of neuron of retina.The irreversible damage of visual function is the unfortunate results of degenerative retinal diseases,and some effective treating approach to these blindness eye diseases is still in expectation.In recent years,stem cells replacement therapy is increasingly developed and is a prospective way for degenerative retinal diseases.But some formidable challenges for successfully grafting cells to the retina are waiting for further solving,such as migration,survival,and differentiation of the stem cells etc.Recent studies showed that retinal tissue engineering technique may be a good alternation to address all the problems mentioned above.The current advances in stem cell and tissue engineering retina researches,including selectable seed cells,appropriate scaffold materials and transferring method in vivo,are reviewed in this paper.

Idiopathic orbital inflammatory pseudotumor(IOIP) is a common orbital disease.It is a nonspecific inflammatory process,and the etiology is still unknown.IOIP occurs at any position of orbit.The clinical manifestation varies according to the anatomic involvement and the degree of inflammation progress.IOIP can clinically mimic many other orbital diseases,especially serious type of this disease can present similar clinical characteristics as the malignant tumor,so it is comprehensive to make a clinical diagnosis.Currently,the diagnosis of IOIP is allowed based on the differentiation from an exclusion of other diseases by a thorough medical history and clinical manifestations,and then acquire some assistant information by radiologic evaluation and laboratory tests and observe the response to steroid treatment.The final diagnosis still requires histopathological examination.