Children with plastic bronchitis,characterized by unknown origin,insidious onset,rapid progress,severe symptom and high mortality,is a relatively rare disease.Also,it is difficult to diagnose and treat with plastic bronchitis characterized by marked airway obstruction,via the formation of large gelatinous or rigid airway cast.It is associated with certain diseases including bronchial asthma,cystic fibrosis,accompanied with acute chest syndrome with sickle cell disease,congenital heart disease and bacterial and viral respiratory infection.Clinicians should be aware of this disease,and early bronchoscopy should be intervened.

Fatigue is one of the most common complaints in cancer patients that profoundly affects all aspects of quality of life.However,cancer-related fatigue remains under recognized and poorly treated.This rcview has been conducted with the causes and potential treatments of fatigue in cancer patients.The methods for evaluating fatigue,and possible therapeutic options are also discussed.

Retinal ischemia-reperfusion injury (RIRI) is a common pathological and physiological clinical oculopathy,which can occur in retinal artery and vein occlusion,diabetic retinopathy and acute angle-closure glaucoma.The resulting ischemia can cause cell metabolic dysfunction,serious retinal damage and descending visual function.RIRI is the result of multiple factors.The currently accepted hypotheses mainly include the injury effect of oxygen-derived free radicals,intracellular calcium overload,the action of leucocyte and apoptosis.However the protection and treatment research in the RIRI is limited.The present paper reviews the progression in the drug intervention of RIRI.

The study aims to observe the clinical efficacy of Baoerkang san on spleen-deficiency and dampness-obstructing diarrhea in children. Children diarrhea divided into acute diarrhea (group I) and chronic persistent diarrhea (group II). A randomized, double-blind, positive control test was conducted for dose finding. The 340 cases with acute diarrhea in group I were divided into three groups: the high dose group (112 patients), the low dose group (113 patients) and the positive control group (115 patients), which were treated for 3 days. Their clinical efficacies were compared to evaluate the clinical safety of Baoerkang san. The 167 patients with chronic persistent diarrhea in group If were divided into the high dose group (56 patients), the low dose group (55 patients) and the control group (56 patients), which were treated for 5 days. Their clinical efficacy were compared to evaluate the clinical safety of Baoerkang san. According to the results, the cure rate and the effective rate of acute diarrhea and chronic persistent diarrhea in the high dose group and the low dose group were significantly higher than that of the positive control group (P <0. 05, P < 0.01). In the treatment of spleen-deficiency and dampness-obstructing diarrhea with traditional Chinese medicines, the cure rate and the effective rate of acute diarrhea and chronic persistent diarrhea in the high dose group and the low dose group were significantly higher than that of the positive control group (P < 0.05, P < 0.01). During the test, all of the three groups did not suffer any adverse event, with no any abnormality in general physical indexes. In conclusion, Baoerkang san shows a significant efficacy in treating acute diarrhea and chronic persistent diarrhea (spleen-deficiency and dampness-obstructing) and safe clinical application.
Child ; Child, Preschool ; Diarrhea ; drug therapy ; physiopathology ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Humans ; Infant ; Male ; Phytotherapy ; Spleen ; drug effects ; physiopathology ; Treatment Outcome

Dermatovenereology have developed rapidly in fields including genodermatology, dermatological epidemiology, skin immunology, infectious skin diseases, clinical diagnosis, drug treatment, light therapy, and sexually transmitted diseases in recent years. Meanwhile, many skin diseases and a few venereal diseases still lack effective ways of treatment and control. More efforts should be made in both basic and clinical researches in the related fields.
Dermatology ; trends ; Forecasting ; Humans ; Venereology ; trends

The pattern/symptom differentiation system in acupuncture treatment is lack of the unique characteristics and advantages in theory and clinical practice and it just rigidly adopts the methods of pattern/symptom differentiation of the other disciplines in TCM. In fact, it is necessary to have the unique and more practical theoretic system to guide acupuncture treatment. According to the characteristics of acupuncture in diagnosis and treatment, the acupoints selection based on "disease-symptom-location" combination becomes the law of acupuncture treatment. The acupoints selection based on "disease-symptom-location" combination is the expression to concretize the diagnosis and treatment of disease under the guidance of pattern/syndrome differentiation. Both of them are originated from the general principles of TCM and for the particular disciplines of TCM. The acupoints selection based on "disease-symptom-location" combination benefits the promotion and application of acupuncture.
Acupuncture Points ; Acupuncture Therapy ; Diagnosis, Differential ; Humans ; Meridians

Cariostatic Agents ; therapeutic use ; China ; Dental Caries ; prevention & control ; Fluorides ; therapeutic use ; Health Promotion ; Humans ; Oral Health

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder of hematopoietic stem cells due to acquisition of somatic mutations.Somatic mutations in phosphatidylinositol glycan class A (PIGA) account for intravascular hemolysis and other PNH manifestations,but the pathophysiology of clonal expansion of PNH cells cannot be elucidated clearly.PNH is closely related to aplastic anemia and myelodysplastic syndromes.Today,the gold standard for PNH is flow cytometry to detect the absence or severe deficiency of glycosylphosphatidylinositol (GPI)-anchored proteins on white and red blood cells.However,PNH diagnosed by phenotype is a group of heterogeneous disease in pathogenesis.Eculizumab,a first-in-class monoclonal antibody that inhibits terminal complement,is highly effective in stopping intravascular hemolysis and improving quality of life.Further research on the pathogenesis of PNH would be helpful to understand the underlying reasons for PNH phenotype cells in different patients,improve differential diagnosis and more targeted and specific therapy.Research progress in recent years will be reviewed in this article.

Objective To explore effects of spinal-epidural anesthesia combined with epidural anesthesia for cesarean section anesthesia and hemodynamic maternal.Methods 122 cases of mothers for cesarean section surgery in Lyuliang Municipal People's Hospital from January 2012 to January 2014 were selected,and they were divided into two groups by randomized single-blind method.The control group (61 cases) was given simple subdural anesthesia (EA),while the observation group was given CSEA.The maternal hemodynamics,efficacy of the anesthesia and adverse reactions were compared between the two groups.Results The onset time of anesthesia,maximum block level,amount of anesthetic in the observation group were (3.87 ± 0.25) min,(5.04 ± 0.41) T,(6.87 ± 0.92) mL,which were significantly reduced compared with the control group (t =8.55,8.03,6.45,all P ＜ 0.05),and the duration of anesthesia was (116.76 ± 7.89) min,which was significantly increased compared with the control group (t =7.93,P＜0.05).The MAP and HR of observation group in T1,T2,T3 showed no significant differences compared with T0 (P ＞ 0.05);while the control group of patients with the MAP at T2 had obvious reduction compared with T0 (t =8.34,P ＜ 0.05),T2,T3 compared with T0 decreased significantly (t =7.87,7.56,all P ＜ 0.05).The incidence rate of adverse reaction in the observation group was 9.84％,which was significantly lower than 24.59％ of the control group,the difference was statistically significant (x2 =9.45,P ＜ 0.05).Conclusion The lumbar epidural anesthesia for cesarean section anesthesia had significantly fewer adverse reactions,and it can remain stable maternal vital signs,which was an ideal cesarean for section anesthesia.

Objective:To study the extraction process of AWei capsule.Methods:Taking the contents of gallic acid and the yield of extracts as assessment index to optimize water extraction process of AWei capsule with orthogonal experimental design.Taking the contents of magnolol,honokiol and the yield of extracts as assessment index to optimize ethanol extraction process of AWei capsule with orthogonal experimental design.Results:The optimal water extraction process of AWei capsule was extracting twice,every time lasted 1.5h,every time added 14 times water.The optimal ethanol extraction process of AWei capsule was using 80%ethanol as solvent,extracting twice,every time lasted 1.5h,every time added 6 times solvent.Conclusion:The optimized extraction process is stable and reasonable.