Autism in children is a complex disease of developmental disorder in nervous system,characterized by social deficits,impaired language and communication,stereotyped and repetitive behaviors.Studies indicate oxidative stress is associated with autism.Because of genic and environmental factors,children with autism are susceptible to oxidative stress.Oxidative stress induce the development of autism through abnormal metabolism of the membrane lipid,inflammation and excitotoxicity,autoimmunity,energy metabolism disorder,et al.Anti-oxidation might be a safe and effective therapy for autism.

Objective To compare and analyze two methods for determination of vaccine particle content in freeze-dried human rabies vaccine(Vero cells)bulk and final bulk,and to provide experimental basis for establishing standard detection method for particle content and purity of rabies vaccine products.Methods The samples were subjected to vaccine particle cracking,BCA quantification,and size exclusion chromatograghy-high performance liquid chromatography(SEC-HPLC)analysis. BCA-SEC relative area method and BCA-SEC vaccine particle standard curve method were used to detect the total protein concentration of the bulk and final bulk,separately,and the content of vaccine particles was quantitatively analy-zed. Finally,the detection results of the two methods were compared and analyzed.Results The content of vaccine particles in freeze-dried human rabies vaccine bulk was determined to be within 256-305 μg/mL by the two methods,with an average value of 267-285 μg/mL,and the relative standard deviations(RSDs)ranged from 5. 8% to 10. 2%,with good consistency between two methods. The content of vaccine particles in freeze-dried human rabies vaccine final bulk was determined to be in the range of 149-169 μg/mL by the two methods,with an average value of 152-164 μg/mL,and the two methods showed the RSDs between 0. 9%-4. 7% with good consistency.Conclusion The measured value by BCA-SEC standard curve method deviates less from the expected value and is closer to the actual situation of samples,so it is recommended to use this method as a reference for enterprises.

The scientific indexes and methods for checking utilization and intact rates of analytical instruments are established by cybernetic principles, fozzy mathemetical mdthods, theories of systematic engineering, and actual conditions of working units. it is proved that the realization of scientific management and control to manipulators, instruments and working enviroment can raise the utilization and intact rates of analytical instruments, guarantee the assay quality of drugs, increase the efficiency of supervision and promote the research work in drug analysis. Definite social and economic results are thus obtained.

The "opening-closing-pivoting" theory on the six meridians is one of the difficult points in the study of Shang Han Lun (Treatise on Cold Diseases). The authors give an explanation on the space and time differentiation of three-yin and three-yang as well as the "opening-closing-pivoting" theory based on the predecessor's experience, and then analyze the physiological and pathological characteristics of the six-meridian disorders.

After the research of PLA2R1 and its antibodies, Thrombospondin type-1 domain-containing 7A and its antibodies to membranous nephropathy (MN) has made a new understanding.Some researches have reported that the antibodies of PLA2R1 and THSD7A were mutually exclusive in MN, because THSD7A was found in PLA2R1-negative MN patients.But the latest researcher showed that these antibodies can be both positive in MN patients.Similar to the function of PLA2R1, THSD7A can assist clinical diagnosis, treatment, and monitor of MN.In contrast to PLA2R1, THSD7A was also highly expressed on both human and murine podocytes.We can use the mice model to study the pathogenesis of THSD7A-associated MN in the future.In this review, we describe the structure and function of Thrombospondin type-1 domain-containing 7A and its autoantibodies, highlight its role in MN and suggest possible aspects of its future clinical application.

[Objective]To provide a reference for the effects of potassium on quality formation of medicinal material. [Methods] Withpotassium,traditional Chinese medicine,growth and development,physiological characteristicsandeffective medicinal substancesas the key words, from June 2012 to March 2017 in the Pub Med, CNKI, WANFANG, VIP, the effects of potassium on the growth and development, production and quality formations, plant physiology, resistance acquirement, medicinal substances in medicinal material were systematically summarized. [Results] A total of 71 articles were retrieved, of which there were 50 valid literatures. At present, the related researches mainly focus on the relationship between potassium and growth and development, yield and quality formation, effective medicinal substances metabolism of Chinese herbs. [Conclusion] Some progresses have been made in this field. But this paper pointed out the problems in this field and put forward the directions about further research of effective medicinal substances metabolism and its mechanism, establishing multiple factor, multilevel nolinear synthesis model.

Surgery, selective radioiodine therapy and thyroid stimulating hormone suppressive therapy are the standard treatment modalities for differentiated thyroid cancer (DTC). After therapy, most DTC patients could get good prognosis. However, some patients with distant metastasis lose the ability to concentrate radioiodine at early time or during the treatment, and develop radioiodine-refractory DTC (RAIR-DTC). These patients progress quickly and have high mortality. Looking for effective treatments for these patients has been the hot spot in research of thyroid carcinoma. In this paper, we summarized the recent advances in the diagnosis and treatment of RAIR-DTC, hoping to early identify these patients and buy time for early intervention of other possible beneficial treatments such as targeted therapy and radiotherapy.

Objective To observe and analyze the clinical effect of Modified Decoction for the treatment of lung -qi and spleen -qi deficiency syndrome in patients with stable stage of chronic obstructive pulmonary disease (COPD).Methods 86 patients with lung -qi and spleen -qi deficiency syndrome in stable stage of COPD were divided into the observation group (n =43) and control group (n =43) according to a random number table method. The control group was treated with conventional western medicine therapy,the observation group was given modified Bufei decoction treatment on the basis of western medicine treatment.The clinical therapeutic effect of two groups was assessed.Results The effective rate of the observation group was 83.72%,which was significantly higher than 72.09% of the control group,the difference was statistically significant (χ2 =3.9289,P <0.05).After treatment,the FEV1 ,FEV1 /FVC,FEV1% expected values of the two groups were significantly higher than those before treatment (t =3.6984,3.6915,3.7431,4.2675,4.6821,5.0567,all P <0.05).After treatment,the FEV1 ,FEV1 /FVC, FEV1% predicted value of the treatment group were (2.45 ±0.35)L/s,(63.91 ±7.42)%,(47.29 ±7.52),which were significantly higher than those of the control group (t =3.6884,3.7581,4.1957,all P <0.05).After treatment, the levels of IL -8 and TNF -αwere not significantly changed in the control group.The levels of IL -8 and TNF -αin the observation group were significantly lower than those in the control group (t =8.864,9.571,all P <0.05). Conclusion In COPD patients of stable stage with lung -qi and spleen -qi deficiency syndrome,plus or minus fill lung soup can effectively relieve clinical symptoms and improve pulmonary function of patients,reduce the acute attack,and improve the quality of life of patients,it is worthy of clinical application.

Objective To explore diagnostic value of the immune intensity of platelet ?-amyloid precursor protein(APP) and isoforms proportion for Alzheimer's disease(AD).Methods The APP immune intensity of platelets was evaluated by flow cytometric detection and the isoforms proportion of APP130/APP106 was also detected by Western Blot analysis in 31 AD cases, 22 vascular dementia (VD) patients , 28 neural degeneration patients and 30 healthy elders.Results There was no significant difference of APP immunity in the each group. The ratio of APP130/APP106 was significantly lower in the AD group compared with the groups VD, degenerative disorder and healthy elders(all P

Objective:The aim of quality control in the key process of clinical laboratory is to provide accurate and reliable and timely clinical laboratory test reports. Methods:Strictly enforce the national development ofmedical institution clinical laboratory management approach, and to quality control from the several important aspects, such as the basic information before clinical examination, clinical laboratory equipment, reagents management, software conditions, issue of test reports, which should ensure quality control throughout the entire process of testing. Results:Thought strengthening of clinical laboratory quality control can greatly improve the accuracy of test results, reduce the test results influence because of subjective and objective factors in the testing process, which will promote and improve the quality of clinical testing. Conclusions:It is important to the quality of clinical laboratory tests and hospital medical quality and safety. Thought strengthening quality control in the key process of clinical laboratory, accurate test data can be provide for clinical diagnosis and treatment, and then effectively improve the level of the hospital.