Animals ; Brain ; drug effects ; pathology ; Humans ; Hypothalamo-Hypophyseal System ; drug effects ; Neuroprotective Agents ; pharmacology ; Pituitary-Adrenal System ; drug effects ; Receptors, GABA-A ; drug effects ; Receptors, Glucocorticoid ; drug effects ; Receptors, N-Methyl-D-Aspartate ; drug effects ; Steroids ; pharmacology

China ; Humans ; Infant, Newborn ; Metabolism, Inborn Errors ; diagnosis ; therapy ; Neonatal Screening ; Phenylketonurias ; diagnosis ; Tandem Mass Spectrometry

Humans ; Lysosomal Storage Diseases ; prevention & control ; therapy ; Lysosomes ; metabolism

The values of vitamin E in serum were decreased significantly in rats with 15% BSA III burn from 1.5 hours to 7 days postburn, and then restored gradually, while the levels of lipid peroxides in serum and lung were increased from 1.5 hours to 3 days. The activities of superoxide dismutase and glutathine peroxidase in blood were also decreased after burns, the former remaining low within 14 days and the latter restoring after 7 days postburn. After intraperitoneal injection of vitamin E to the burned rats, the overproduction of lipid peroxides in serum and lung was inhibited with inhibition rates of 28% and 31%, respectively. No more pathological changes of ultrastructural picture were observed in lung of the burned rats supplemented with vitamin E as compared to the control. The results showed that it was beneficial to supply vitamin E in treatment of burns as soon as possible.

Recently,considerable progress has been made in the treatment of systemic lupus erythematosus(SLE),especially in the clinical use of new immunosuppressive agents,which leads to improved remission rate and life quality.However,plasmapheresis still shows to be necessary in severe lupus with serious complications.With the development of plasmapheresis technology,the efficiency and specificity of antibody adsorption being improved significantly,it played an important role in the treatment of acute stage life-threaten lupus.Here we intend to make a review on the relative improvement of plasmapheresis technology and its clinical use.

Animals ; Clinical Trials as Topic ; Drugs, Chinese Herbal ; pharmacology ; therapeutic use ; Drugs, Investigational ; Humans ; Liver ; pathology ; Liver Cirrhosis ; drug therapy ; prevention & control

Colorectal Neoplasms ; pathology ; Humans ; Neoplasm Staging

Objective To investigate the value of selective water excitation technique for the assessment of articular cartilage.Methods MR sagittal scanning of knee joints was performed in the fifteen healthy volunteers.MR scan sequences were 3D-FFE-SPIR and 3D-FFE-WATS.The signal noise ratio (SNR)of the cartilage,the contrast noise ratio(CNR)between cartilage and adjacent tissue and their efficiency were calculated and analyzed statistically.Tweenty-nine patients who were suspected having cartilage injury were performed MR examination anti the image characteristics and the detecting ability of each sequence on cartilage lesions were analyzed.Results In the healthy volunteers,the cartilage SNR was 3D-FFE-SPIR:197.93?18.58,3D-FFE-WATS:187.32?21.50(P=0.159).CNR(cartilage/bone)was 3D-FFE-SPIR:185.50?18.34,3D-FFE-WATS:169.55?24.57(P=0.054).CNR(cartilage/muscle)was 3D-FFE-SPIR:61.40?19.04,3D-FFE-WATS:47.27?21.05(P=0.064).The cartilage SNR and CNR between cartilage and bone,muscle of 3D-FFE-SPIR weren't significantly higher than that of 3D-FFE- WATS.CNR(cartilage/liquid)was 3D-FFE-SPIR:91.53?14.46,3D-FFE-WATS:149.28?32.30(P= 0.000).CNR(cartilage/marrow)was 3D-FFE-SPIR:159.26?18.83,3D-FFE-WATS:176.87? 22.50(P=0.028).CNR(cartilage/fat)was 3 D-FFE-SPIR:134.56?15.80,3D-FFE-WATS:154.01? 22.42(P =0.010).The CNR between cartilage and liquid,marrow,fat were higher in 3D-FFE-WATS and significantly different than that of 3D-FFE-SPIR.Thirty detected cartilage injuries of patients were 3D-FFE- WATS:39,3D-FFE-SPIR:45 and there was no statistical difference between them(P=0.37). Conclusion 3D-FFE-WATS can show the articular cartilage clearly.It has high scan speed and suppress the fat signal evenly.Its ability for finding cartilage damage is equal to that of 3D-FFE-SPIR.So WATS can be used in the routine clinical cartilage examination.

Objective To study the repairing effects of nerve growth granule(NGG) on rat common peroneal nerve transection injury.Methods After 50 Sprague-Dawley rats were subjected to nerve suture after transaction,they were randomly divided into 5 groups for daily intragastric administration of drugs:NGG high-dose(5.2g/kg),medium-dose(2.6g/kg),low-dose(1.3g/kg) groups,mecobalamin group(positive control) at 625 ?g/kg,control group(control group control).The drug administration lasted for 4 weeks.Footprint test was performed 2-,3-and 4-weeks after surgery to evaluate toe spread function(TSF).Electrophysiology was performed 4 weeks after operation to determine the compound muscle action potential(CMAP) and nerve action potential(NAP).The number of regenerated myelinated nerve fibers,thickness of myelin sheath and cross sectional area of tibial muscle were measured by histomorphology.Results TSF,amplitude and recovery rate of CMAP and NAP,the number of regenerated myelinated nerve fibers,thickness of myelin sheath and section area of tibial muscle were all increased significantly in a dose-dependent manner compared with the control group.Conclusion NGG contributes to axon growth and myelination,and thus promotes peripheral nerve regeneration in rats with functional recovery.

Objective　To study killing effect of plasmas ozo ne water on microorganisms by plasmas ozone disinfection solution through plasma s ozone resulting from discharge along surface disinfection solution produced by machine and its effect factors. Methods　Quantitative solut ion test was used to study killing action of plasmas ozone disinfection water to E. coli and staphyrococcus aureus, and to study its eff ect factors. Results　Plasmas ozone water could kill 99.9% E. coli and staphyrococcus aureus after 15 min. The kill ing effect was affected by organism. With the increasing of organism concertrat ion, the killing efficacy increased. Conclusions　Plasmas ozone can effectively kill microorgnisms in water and the efficacy was affected by org anism.