Objective To investigate the effect of borneol on levels of monoamine neurotransmitters in the prefrontal cortex of rat after long-term continuous operations.Methods A rat model of long-term continuous operations were established by using a treadmill protocol.Then Borneol(0.4 g/kg,p.o.) was given to the rats after the operation,and their activity-rest behavior and active avoidance response were assessed.Two h later,the rats were sacrificed and the level of monoamine neurotransmitter in the prefrontal cortex was determined by high performance liquid chromatography combined with electrochemical detection(HPLC-ECD).Results After the administration of borneol,the activities of operational animals were increased markedly as compared with that of vehicle operational group.The operational rats after borneol application had less response time than the ones treated with vehicle(6.85?1.24) s in active avoidance response.The levels of monoamine neurotransmitters including noradrenaline,dopamine,and 5-serotonin in the prefrontal cortex were decreased after treadmill operation.While application of borneol made the levels of noradrenaline and 5-serotonin increased significantly as compared to operational group.Conclusion Borneol have a reversal effect on rat awake activity impairment after long-term continuous operations.And the arousal effects of borneol are associated with the increase of noradrenaline and 5-serotonin levels in the prefrontal cortex.

So far,the unified definition and diagnostic criteria of feeding intolerance in preterm infants is still unavailable,although they have always been modified and improved.The curative effects of intervention strategies,including the feeding strategies,breast-feeding,medication,and so on,still need multiple clinical randomized studies in order to be verified and evaluated.Therefore,this article will summarize the progress in the definition of feeding intolerance,feeding strategies and medication.

Objective To explore the management status of long term care hospital nursing workers and find out appropriate countermeasures.Methods By using the methods of questionnaire survey and interview,management status of nursing workers from similar hospitals was investigated.The results were explored and applied combined with the nursing management of our hospital.Results Satisfaction degree of patients and their families about nursing workers increased from 76.7％ to 97.4％.Conclusions It is of key importance that continuous exploration and improvement of hospital nursing workers management be implemented to enhance the high quality nursing of elderly chronic disease hospital.

Neuroblastoma(NB) is the most common extracranial solid malignant tumor in childhood,which has various clinical manifestations.Tumor metastasis or relapse is one of the major causes of death in patients with NB.At present,the treatments of NB are mainly concentrated on the surgery,chemotherapy,radiation therapy,myeloablative therapy and transplantation,tumor targeted therapy,etc.But the treatment of children with high-risk NB is still not optimistic.Studies have shown that multidmg resistance is a major impediment to the successful treatment of NB.Hence,it is of great significance to have a comprehensive understanding of the chemoresistance mechanisms to improve the survival rate of NB patients.This review discusses the chemoresistance mechanisms of NB in several respects.

Objective Onto observe the curative effect of carboprost tromethamine injection combined with mifepristone on the treatment of the patients with risky placenta previa. Methods 66 cases with placenta previa during mid pregnancy from January 2016 to December 2016 in Dingbian county people's hospital were randomly divided into two groups, 33 cases in the control group and 33 cases in the observation group. All patients were received cesarean section and traditional treatments such as oxytocin and gauze filling. Hemostatic effect, prognosis and incidence of adverse reactions in the two groups were compared. Results The intraoperative bleeding volume, the amount of vaginal bleeding 2 hours after operation and the amount of vaginal bleeding 2 to 24 hours after operation in the observation group were less than those in the control group (P<0.05). The rate of postpartum hemorrhage, the rate of disseminated intravascular coagulation and the incidence of puerperal disease in the observation group were significantly less than those in the control group (P<0.05). The sanguinous lochia time and menstrual recovery time in the observation group were better than those in the control group (P<0.05). There was no significant difference in the rate of hysterectomy and adverse reactions between the two groups. Conclusion Carboprost Tromethamine Injection combined with mifepristone in the treatment of pernicious placenta previa can effectively reduce the bleeding rate and promote the rehabilitation of pregnant women. It is safe and has no obvious adverse reactions. It is worthy of clinical application.

OATP1B3, a member of SLC superfamily, is specifically expressed on the sinusoidal membrane of hepatocytes and is considered to be important in hepatic drug elimination. The overexpression of OATP1B3 was found recently in tumor tissues such as prostate, colon, and pancreatic tumors. Sequence variations in SLCO1B3 gene, such as SNPs, have been described and a common haplotype consisting of 334T>G and 699G>A SNPs is related to altered transport characteristics of OATP1B3. OATP1B3 is of relevance to drug metabolism through affecting alteration of hepatic concentration of endo- and xenobiotic compounds that interact with nuclear receptors such as PXR and CAR, and thereby directly alter the extent of target gene transcription, including major CYP isoenzymes such as CYP3A4. This review will provide an overview of substrates and inhibitors of OATP1B3 and subsequently to assess the effect of genetic mutation on transport activity. The studies linking OATP1B3 with cancer clinical outcomes are also discussed in this review.

The study aims to observe the clinical efficacy of Baoerkang san on spleen-deficiency and dampness-obstructing diarrhea in children. Children diarrhea divided into acute diarrhea (group I) and chronic persistent diarrhea (group II). A randomized, double-blind, positive control test was conducted for dose finding. The 340 cases with acute diarrhea in group I were divided into three groups: the high dose group (112 patients), the low dose group (113 patients) and the positive control group (115 patients), which were treated for 3 days. Their clinical efficacies were compared to evaluate the clinical safety of Baoerkang san. The 167 patients with chronic persistent diarrhea in group If were divided into the high dose group (56 patients), the low dose group (55 patients) and the control group (56 patients), which were treated for 5 days. Their clinical efficacy were compared to evaluate the clinical safety of Baoerkang san. According to the results, the cure rate and the effective rate of acute diarrhea and chronic persistent diarrhea in the high dose group and the low dose group were significantly higher than that of the positive control group (P <0. 05, P < 0.01). In the treatment of spleen-deficiency and dampness-obstructing diarrhea with traditional Chinese medicines, the cure rate and the effective rate of acute diarrhea and chronic persistent diarrhea in the high dose group and the low dose group were significantly higher than that of the positive control group (P < 0.05, P < 0.01). During the test, all of the three groups did not suffer any adverse event, with no any abnormality in general physical indexes. In conclusion, Baoerkang san shows a significant efficacy in treating acute diarrhea and chronic persistent diarrhea (spleen-deficiency and dampness-obstructing) and safe clinical application.
Child ; Child, Preschool ; Diarrhea ; drug therapy ; physiopathology ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Humans ; Infant ; Male ; Phytotherapy ; Spleen ; drug effects ; physiopathology ; Treatment Outcome

In recent years,a lot of researches have shown microRNA (miRNA) involved in every link of epithelial-mesenchymal transition(EMT) regulation process through a variety of signaling pathways in tumor; even the same kind of miRNA plays significantly different roles in different tumors,inducing great significance to guide clinic.

Objective;To test the relationship between Collective Self-Esteem,Self-Esteem and Depression,Anxiety.Methods;800 freshmen completed the Collective Self-Esteem Scale,the self-Esteem Sale,Self-Rating Depression Scale and Self-Rating Anxiety Scale.Results;①The rate of slight depression was 21.6%;moderate depression,5.9%;high depression,1.6%.The mean of anxiety was 42,the mode of anxiety was 36.②The predicting effects of Self-Esteem,private collective self-esteem and public collective self-esteem on depression were significant(P

Objective To investigate the clinical effect of internal fixation and bone graft in surgical reduc-tion of different types of tibial plateau fractures.Methods 90 patients with tibial plateau fractures were selected. They were divided into observation group (60cases) and control group (30cases).The observation group treated with operative reduction of internal fixation and bone grafting for the treatment,and the control group were treated by calca-neal traction and plaster external fixation.The effect,joint function recovery and complication occurrence were com-pared between the two groups.Results The excellent and good rate was 90.00%in the observation group,which was significantly higher than that in the control group (66.67%),the difference was significant (χ2 =11.211 7,P<0.05);The HSS score was respectively (70.3 ±5.9)points and (84.2 ±3.2) at 3 and 6 months after treatment in the observation group,it was significantly higher than that of the control group (t=4.107 3,5.397 1,all P<0.05);the postoperative complication rate was 8.33%in the observation group,which was significantly lower than that in the control group,the difference was significant (χ2 =7.284 3,P<0.05).Conclusion Internal fixation and bone graft in surgical reduction is proved to be effective in treating the patients with different types of tibial plateau fractures.It can promote the recovery of joint function of the patients,which has high safety,and is worthy to be popularized.