1.Heritability and genetic correlation of body mass index and coronary heart disease in Chinese adult twins
Yu′e XI ; Wenjing GAO ; Xuanming HONG ; Jun LYU ; Canqing YU ; Shengfeng WANG ; Tao HUANG ; Dianjianyi SUN ; Chunxiao LIAO ; Yuanjie PANG ; Zengchang PANG ; Min YU ; Hua WANG ; Xianping WU ; Zhong DONG ; Fan WU ; Guohong JIANG ; Xiaojie WANG ; Yu LIU ; Jian DENG ; Lin LU ; Weihua CAO ; Liming LI
Chinese Journal of Preventive Medicine 2022;56(7):940-946
Objective:To examine the heritability of body mass index (BMI) and coronary heart disease (CHD), and to explore whether genetic factors can explain their correlation.Methods:Participants were from 11 provinces/municipalities reqistered in the Chinese National Twin Registry (CNTR) from 2010 to 2018. Participants data were collected from face-to-face questionnaire survey. Bivariate structure equation model was used to estimate the heritability and the genetic correlation of BMI and CHD.Results:A total of 20 340 pairs of same-sex twins aged ≥25 years were included in this study. After adjusting for age and gender, the heritability of BMI and CHD was 0.52 (95% CI: 0.49-0.55) and 0.76 (95% CI: 0.69-0.81), respectively. Further, a genetic correlation was identified between BMI and CHD ( rA=0.10, 95% CI:0.02-0.17). Conclusion:In Chinese adult twin population, BMI and CHD are affected by genetic factors, and their correlation can be attributed to the common genetic basis.
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