Objective To explore the effects of quetiapine combined with sertraline in the treatment of schizophrenia patients with depressive symptoms.Methods 86 patients of convalescence of schizophrenia with depression symptoms were randomly divided into quetiapine combined with sertraline group(observation group) and quetiapine group(control group).The treatment course was 8 weeks.Before and after treatment,the positive and negative symptoms scale (PANSS) and Hamilton depression scale (HAMD) were assessed in the two groups.The curative effect of quetiapine combined with sertraline on the schizophrenia patients with depression symptoms was explored.Results Pre-treatment,there were no differences in the two groups on PANSS score (t =-0.432,P ＞ 0.05),HAMD score (t =0.424,P ＞ 0.05).Post-treatment,there were significant differences between the two groups in PANSS score (t =18.780,P ＜ 0.05;t =12.256,P ＜ 0.05) and HAMD score (t =6.542,P ＜ 0.05;t =4.107,P ＜0.05).There were significant differences between the two groups in HAMD score (t =6.612,P ＜0.05).Conclusion Quetiapine can significantly improve the effects of positive and negative symptoms and depressive symptoms of schizophrenia patients with depression symptoms.Quetiapine combined with sertraline can improve the depressive symptoms of schizophrenia better compared with quetiapine.