Animals ; Dental Implantation, Endosseous ; Dental Implants ; Dental Implants, Single-Tooth ; Denture, Complete, Immediate ; Denture, Partial, Immediate ; Humans ; Immediate Dental Implant Loading ; methods ; Jaw, Edentulous ; rehabilitation ; Jaw, Edentulous, Partially ; rehabilitation ; Mandible ; Maxilla

OBJECTIVE: To intensify ward management on high-alert medications ensure clinical medication safety.METHODS: The main problems encountered in ward management on high-alert medications were analyzed;the application of continuous quality improvement(CQI) in the management on high-alert medications was introduced and the outcome was evaluated.RESULTS: The continuous quality improvement has greatly enhanced the management quality on high-alert medications and reduced the number of problems from previous 158 times before practice to 2 times after the practice of the continuous quality improvement.CONCLUSION: CQI is a continuous activity and it is conducive to the improvement of management quality on high-alert medications.

Objective To review the characteristics,mechanism,the brain structural and functional changes of cognitive impairment induced by sleep-disordered breathing in children.Methods The retrieve time was from 2002 to 2014 and the retrieve databases were the US.national library of medicine and Weipu Chinese journal databases.Search word included sleep disorders breathing, cognitive, sleep apnea syndrome, neurobehavioralmanifestations,image,sleep deprivation.Results 52 English literature and 1 Chinese literature were accepted.Most literatures were clinical trial, comparative study, multicenter study, randomized controlled trial, controlled clinical trial.Conclusion The study in the cognitive impairment and characteristics change of the brain function and structure in children with SDB is not enough.Most cognitive assessments are completed by scale.How to diagnosis early,more objectively assess cognitive, study molecular mechanisms, study function change and positioning of brain function need more research in clinical.

Humans ; Occupational Diseases ; prevention & control ; Risk Assessment ; Safety

Confronted with many problems such as the aged population, increase in the demand for long-term care and financial pressure resulted from the previously defective social security system, after years of efforts, Germa-ny eventually succeeded in putting forward an effective national compulsory long-term care system in 1994 . The sys-tem which is based on the original health insurance system and supports multiple payments involves both local govern-ments and private organizations. Specific rules are clarified in terms of the insurance relations, application qualifica-tions, payment conditions and financial mechanism. Shares and contributions of the long-term care have been in-creased after years of practice. Besides, the number of applicants and beneficiaries is rising. Yet on the other hand, problems and controversies still exist in service quality, qualifications and contents for application and financial mech-anism. Germany’s experience in improving the social security system, the quality management of long-term care and effective control of financial balance serves as a significant reference for China in planning and implementing long-term care insurance system.

A total of 446 hyperuricemic patients were divided randomly by community-based cluster sampling into study (n =228) and comparison (n =218) groups.After 12-month health interventions,the Knowledge-Attitude-Performance (KAP) questionnaire [(19.0±4.7) points],lifestyle (balanced diet,modest physical exercises & regular monitoring) self-report questionnaire [attitudes prevention awareness:(8.3 ± 6.1) points,disease self-management behaviors:(13.2 ± 9.8) points],uricacid index [(395 ± 46)mmol/L] and body mass index (BMI) [(23.1 ± 2.3)kg/m2] were better than those at pre-intervention in study group [(9.3 ± 2.7),(4.6 ± 3.9),(7.4 ± 6.4)],[(420 ± 44)mmol/L,(24.9 ± 1.6) kg/m2] (P ＜ 0.05).Also the inter-group difference had statistical significance (P ＜ 0.05).It suggests that health intervention management is both feasible and effective in improving the KAP of patients,modulating lifestyles and lowering the levels of uric acid index and BMI.

OBJECTIVE:To investigate the improvement effect of Eucalyptol enteric soft capsule on mice with lipopolysaccha-ride(LPS)-induced acute lung injury(ALI). METHODS:60 mice were randomly divided into blank control group,model control group,Eucalyptol enteric soft capsule low-dose,medium-dose,high-dose groups(100,300,900 mg/kg),12 in each group. Mice in administration groups were intragastrically given relevant medicines,mice in blank control group and model control group were intragastrically given equal volume of normal saline(0.1 mL/10 g). After 2 h of administration,except for the blank control group, ALI was induced in other groups by atomized LPS. After 6 h of modeling,the mice were sacrificed,alveolar lavage fluid(BALF) and lung tissue were taken. Morphological changes of lung tissue were observed under microscope;number of total cells,neutro-phils in BALF were calculated by blood cell count plate and staining by wright-giemsa respectively. Total protein concentration in BALF supernatant was detected by BCA method;TNF-α,IL-6 contents in BALF supernatant were determined by enzyme-linked immunosorbent assay. RESULTS:Compared with blank control group,lung tissue of mice in model control group showed obvious pathological damage and severe pulmonary edema;number of total cells,neutrophils in BALF,total protein concentration and TNF-α,IL-6 contents in BALF supernatant were significantly increased(P<0.01). Compared with model control group,pathologi-cal damage in lung tissue of mice was obviously improved in Eucalyptol enteric soft capsule high-dose group,number of total cells,neutrophils in BALF,total protein concentration and TNF-α,IL-6 contents in BALF supernatant were significantly decreased (P<0.05);and there were no significant differences in other groups (P>0.05). CONCLUSIONS:High-dose Eucalyptol enteric soft capsule can obviously improve LPS-induced ALI of mice.

Gray Platelet Syndrome ; Humans

The test concludes the existing prominent problems and main damages on medical morality recently in China,and it also discusses the necessity and feasible ways to reinforce the medical moral construction from the two aspects of theory and practice under social market economical condition.

Objective To investigate the expression and significance of inducible co-stimulator (ICOS) in experimental autoimmune uveoretinitis (EAU). Methods EAU was induced in 24 Lewis rats (immune group) by immunization with retinal S-antigen (50 ?g) and complete Freund′s adjuvant, and another 4 rats were in the control group. Anterior segment of the rats′ eyes were observed by split microscope every day. Immunohistochemical staining was performed using polyclonal antibodies to ICOS on the sections of the spleen which were obtained from the rats in immune group at the 7th, 12th, 15th and 21st days after immunisation respectively. Western blotting was performed to investigate the dynamic expression of ICOS protein in the spleen. The same procedures were made at the corresponding time points in the rats in control group. Results A few ICOS positive cells were observed in the normal spleen. The number of ICOS positive cells in immune group increased obviously at the 7th and 12th days after immunization, reached the peak at the 15th day, and decreased at the 21st day which was still higher than that in the control group. The result of Western blotting showed that the dynamic changes of ICOS protein was identical with the changes of positive-cell number detected by immunohistochemistry. Conclusions The enhanced expression of ICOS happens before EAU occurs, which increases when the inflammation occurs and deteriorates, and decreases at the alleviative stage of EAU. It suggests that ICOS participates in the formation, development and disappearance of EAU and plays an important role in the incidence of EAU.