Through PubMed, CNKI and other databases to retrieve original documents about the maintenance treatment of advanced colorectal cancer, collect and analyzed research theory and progress in the maintenance treatment of advanced colorectal cancer. The clinical efficacy of maintenance therapy are evaluated and the patient's disease-free survival and quality of life are observed. The Result shows that the maintenance treatment can improve disease-free survival of advanced colorectal cancer patients, and the toxicity of maintenance treatment can still be tolerated. So the maintenance treatment of advanced colorectal cancer has better clinical efficacy, it is worth to study in the future.

Objective To explore the curative effect of loop electrosurgical excision procedure (LEEP) on cervical intra-epithelial neoplasia(CIN) infected with high risk human papilloma virus (HR-HPV).Methods 80 CIN patients with HPV infection underwent LEEP were selected.HR-HPV DNA load was detected before operation and 3 months after operation,and at the same time,vaginal examination and cervical directed biopsy were conducted.Results Before LEEP operation,the differences between different levels of CIN HPV load were not significant(P ＞0.05,F =0.45).3 months after operation,CIN Ⅰ grade 19 cases (86.4％) turned to chronic inflammation,CIN Ⅱgrade 36 cases (83.7％) turned to chronic inflammation,CINⅢ grade 13 patients (86.6％) were chronic inflammation.Cervical HPV load postoperatively negative rate was 85％ and the lower HPV load,the higher postoperatively negative rate.Conclusion LEEP is the effective treatment for cervical lesion and can significantly decrease the HPV-DNA loading at cervix.

Objective To investigate the method of early termination of cesarean scar pregnancy (CSP).Methods Clinical data of 12 patients with CSP were retrospectively analyzed,all patients were treated with mifepristone 25mg in the morning and evening for 3 days,and misoprostol 600μg in the morning at the fourth days.Results Of 12 patients,medical abortion were completely in 4 cases,and 6 cases were failure which were carried out painless abortion with microtubules(disposable suction tube).2 cases were taken curettage because of hemorrhage after incomplete abortion.1 case was improved by massage the uterus,and intramuscular injection of oxytocin 20u in cervix;another one case was taken uterine artery embolization because of postoperative bleeding about 2 000ml with shock symptoms.Conclusion The CSP is complicated,the early prevention and treatment must be taken for it,and once it diagnosed,the termination of pregnancy should be immediately taken,in patients with a history of cesarean section line miscarriage may occur when the hard-to-control bleeding.Uterine artery embolization is an effective treatment method for the first choice.

Objective To evaluate the effects of selective mesenteric angiography with continuous papaverine perfusion for the diagnosis and treatment of non-occlusive mesenteric ischemia(NOMI).Methods Eighteen patients with NOMI underwent selective superior mesenteric arteriography and papaverine perfusion via the SMA simultaneously were analized retrospectively.Results Fifteen out of the 18 cases recovered;2 cases underwent laparotomy;1 case died within 10 days.Conclusion Selective superior mesenteric arteriography with continuous papaverine perfusion is an effective diagnostic and therapeutic method for non-occlusive mesenteric ischemia.(J Intervent Radiol,2006,15:209-212)

Cervical artificial disc replacement (CADR) as a new method for the treatment of cervical spondylosis, is becoming a basic and clinical research. Compared with the anterior cervical discectomy and fusion (ACDF), the biggest difference of CADR lies in the reconstruction of the cervical vertebra height and physiological curvature, retaining the spinal physiological function maximally and reducing the degenerative changes in adjacent segments. A large number of clinical investigation have suggested that ACDR can become an operation method to replace the ACDF. However, the complications and the problems of prosthesis itself are gradually exposed, such as that the prosthesis, can't completely simulate the biological effects of human intervertebral disc, the other factors and including the operation methods and prosthesis itself. At the same time, the problem that how to prevent complications and problems is required to be solved. Whether, the effect of CADR on the activity of the operation segment, and the prevention of adjacent segment degeneration can be guaranteed for a long time has drawn more and more attention from scholars.
Cervical Vertebrae ; surgery ; Humans ; Postoperative Complications ; etiology ; Total Disc Replacement ; adverse effects

Objective:To explore the clinical effect of glucocorticoid methylprednisolone combined with the conventional treatment on severe hand-foot-mouth disease ( HFMD) in children. Methods:One hundred and twenty children with severe HFMD from our hos-pital were randomly divided into the hormone group and non-hormone group with 60 cases each. The non-hormone group was treated with western routine therapy, and the hormone group was treated with glucocorticoid methylprednisolone 2mg·kg-1 ·d-1 additionally. The changes in such symptoms as fever, rash, surprised and chatter, drowsiness and shock were recorded in all cases. The disappear-ance time of febrile, shock and herpes and hospital stay were compared between the two groups. Results:The clinical effect of the hor-mone group was better than the non-hormone group;it could shorten the disappearance time of febrile, shock, herpes and pharyngeal buccal redness (P<0. 05), while showed no effect on the hospital stay. Conclusion:Glucocorticoid combined with the routine thera-py in the treatment of severe HFMD in infants exhibits better clinical effect.

Thirty cases of hiccup due to cerebral disorders were treated by injecting 2 ml of Angelica(another 30 cases were treated by muscular injection of 30 mg of metoclopramide as the control group.After the treatments for three days, the total effective rate was 100% in the former and 83.3% in the latter.

Non-muscle invasive bladder cancer (NMIBC) represents the malignant tumor of urinary bladder which is limited to mucosa and submucosal.NMIBC has high recurrence,and can progress to muscle invasive bladder cancer.Adjuvant intracavitary perfusion is beneficial for patients after surgery.There are many drugs for intravesical instillation in clinic.However,the new bladder perfusion drug which is safer and more effective,is always a research hotspot.