1.Updated research progress of selective PPARγ modulators
Yi HUAN ; Jun PENG ; Xuan PAN ; Zhan-zhu LIU ; Zhu-fang SHEN
Acta Pharmaceutica Sinica 2021;56(2):352-359
Thiazolidinediones (TZDs) are currently the only recognized insulin sensitizers available for the clinical treatment of type 2 diabetes. Although their advantages are recognized, the profiles of numerous adverse effects hinder the continued use of these drugs. Peroxisome proliferator-activated receptor
2.Significance of Changes of Serum Beta 2-Microglobulin,Cytocine Levels in Childhood Idiopathic Thrombocytopenic Purpura
jin-kai, WEI ; xiao-wei, YANG ; yu-huan, LIU ; xuan, SHI ; yue-hong, XU
Journal of Applied Clinical Pediatrics 2006;0(21):-
Objective To study the changes and significance of serum beta 2-microglobulin(?2-MG),cytocine interleukin-2(IL-2) in the clinical progress of childhood idiopathic thrombocytopenic purpura(ITP).Methods One hundred and ten patients of childhood ITP were chosen for the test group(70 cases of primary ITP and 40 cases of recurrent ITP),and 110 normal children for the control group.Levels of serum ?2-MG and IL-2 were determined by radioimmunoassay kit and analysed with two sample t-test.Results Among the patients,the serum IL-2 levels were significantly lower and serum ?2-MG levels were significantly higher than those in control group(P0.05).Conclusion Determining serum IL-2 and ?2-MG levels has important significance to reflect the progress of disease and direct treatment.
3.Clinical analysis on six cases of hepatic myclopathy.
Li KONG ; Zhong-xuan REN ; Su-huan ZHANG
Chinese Journal of Hepatology 2004;12(2):107-107
Adult
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Humans
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Liver Cirrhosis
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complications
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Male
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Middle Aged
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Spinal Cord Diseases
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etiology
5.Effect of rehabilitation treatment using the assistive devices for children with cerebral palsy
Shuxin ZHANG ; Qing DU ; Huan WANG ; Peijie CHEN ; Jianan LI ; Xuan ZHOU ; Nan CHEN ; Xiaojie LI ; Chao WU
Chinese Journal of General Practitioners 2012;(10):753-756
Objective To investigate the effect of the synthetic rehabilitation treatment using the assistive devices for children with cerebral palsy.Methods 60 outpatients (male 31,female 29) diagnosed as cerebral palsy in our hospital from June 2009 to June 2010 were divided into trial group (n =30) and control group (n =30).Both of the two groups received our rehabilitation treatment three times a week.Compared with the daily family rehabilitation training of the control group,trial group still received a daily rehabilitation treatment by their parents using the assistive devices under the guidance of the therapist.They were assessed with Gross Motor Function Measure 66 items version (GMFM-66)and 88 items version (GMFM-88) before and after 6 months treatment.Results The total score of GMFM-66 and each dimension score of GMFM-88 improved in both group after 6 months treatment,except the centrol group Lying & Rolling dimension.Trial group 51 ± 13 vs.44 ± 15,control group 42 ± 17 vs.38 ± 16 (t =-3.580,P =0.001).There was significant difference on the total score of GMFM-66 and the three dimensions score (Lying & Rolling,Sitting and Walking,Running & Jumping) of GMFM-88 between two group.Lying & Rolling:F =4.59,P =0.036; Sitting:F =6.40,P =0.014 ; Walking,Running & Jumping:F =4.35,P =0.041.Conclusion The synthetic rehabilitation treatment in Medical institutions associate with family rehabilitation treatment using the assistive devices can effectively improve the recovery of gross motor function in children with cerebral palsy.
6.Surrogate biomarkers identification for neuropsychiatric lupus by proteomic fingerprint technology
Huan CHEN ; Ling SUN ; Hua CHEN ; Chaojun HU ; Yongzhe LI ; Peng WANG ; Jing XIE ; Denian BA ; Wei HE ; Xuan ZHANG
Chinese Journal of Rheumatology 2012;16(6):402-405
Objective To identify biomarkers in cerebrospinal fluid (CSF) by proteomic technology and develop a diagnostic model for neuropsychiatric lupus (NPSLE).Methods CSF proteomic spectra of 27 patients with NPSLE before and after treatment,and 27 controls including 17 patients with scoliosis,and 10 SLE patients without neuropsychiatric manifestation (non-NPSLE) were generated by matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) combined with weak cationic exchange (WCX) magnetic beads.Data were analyzed with t test,non-parametric Kruskal-Wallis H test or Wilcoxon sign-rank test.A decision tree model for NPSLE classification was built based on the discriminating peaks.In addition,CSF samples of 12 patients with NPSLE,12 patients with lumbar disc herniation and 9 patients with other neurological conditions were employed as blind test group to verify the accuracy of the model.Results Twelve discriminating mass-to-charge (m/z) peaks were identified between NPSLE and controls.The diagnostic decision tree model,built with a panel of m/z peaks 8595,7170,7661,7740 and 5806,recognized NPSLE with the sensitivity and specificity of 92.6% and 92.6% based on training group samples,91.7% and 85.7% based on blind test group,respectively.Conclusion Potential CSF NPSLE biomarkers are identified by proteomic technology,the novel diagnostic model is sensitive and relatively specific for the diagnosis of NPSLE.
7.Ultrasonographic diagnosis of benign cystic lesions in the scrotum.
Wei-feng XUAN ; Hong-huan ZHANG ; Yi CHEN
National Journal of Andrology 2007;13(9):807-809
OBJECTIVETo investigate the ultrasonographic characteristics of benign cystic lesions in the scrotum.
METHODSA total of 96 patients with benign cystic lesions in the scrotum were analyzed retrospectively.
RESULTSEighteen of the patients had benign cystic lesions in the testis, including 9 cases of intratesticular cystic lesion, 5 tubular ectasia of the rete testis, 2 epidermoid cyst and 2 dermoid cystine. And 78 of the total number had the lesions in the epididymis, including 75 cases of seminal cyst and 3 seminal fluid deposition in the epididymis. High-frequency ultrasound could clearly reveal benign cystic lesions in the scrotum, differentiate them from cystis degeneration of testiculoma, and diagnose tubular ectasia of the rete testis and seminal fluid deposition in the epididymis.
CONCLUSIONUltrasonography could be a first choice and a valuable imaging means in the diagnosis of benign cystic lesions in the scrotum.
Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Cysts ; diagnostic imaging ; Genital Diseases, Male ; diagnostic imaging ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Reproducibility of Results ; Retrospective Studies ; Scrotum ; Ultrasonography ; methods
8.Factors of influence on quality evaluation of adhesive property on cataplasma.
Huan-yu KONG ; Hui ZHOU ; Hong-gang ZHONG ; De-long WANG ; Xuan WANG
China Journal of Chinese Materia Medica 2004;29(10):947-950
OBJECTIVETo provide experimental proof for establishing a standard quality evaluation method of adhesive property on Cataplasma by studying the factors of effect on evaluation of adhesive quality on Cataplasma.
METHODWith 180 degrees peel off test, tensile shear and adhesive force test, the influence caused by the square of samples, texture of fabric base and the moisture loss was tested with multifunctional material tester and first stickiness tester.
RESULTThe peel off strength of 40 mm wide sample is 26% lower than that of the 20 mm wide sample (P < 0.05), and tensile shear strength had no significant difference. The peel off strength of transverse fabric base was higher than that of lengthways fabric base (P < 0.01). The tensile shear strength of transverse fabric base was lower than that of lengthways fabric base (P < 0.05). The sample with 35% moisture lost had a maximum tensile shear strength and the sample which lost 30% moisture lost had a maximum peel off strength; The sample which lost 20% moisture lost had a maximum first adhesive force.
CONCLUSIONThe square of samples, the texture of fabric base and the moisture loss of samples can all affect the evaluation of adhesive quality on Cataplasma.
Adhesiveness ; Drugs, Chinese Herbal ; administration & dosage ; standards ; Materials Testing ; methods ; Ointment Bases ; chemistry ; Ointments ; chemistry ; standards ; Quality Control ; Tensile Strength
9.Mechanisms of bone marrow mesenchymal stem cells plus normothermic mechanical perfusion alleviating hepatocyte apoptosis after donation after cardiac death transplantation in rats
Longlong WU ; Mengshu YUAN ; Ling LIN ; Xuan TIAN ; Weiping ZHENG ; Huan CAO ; Hongli SONG
Chinese Journal of Organ Transplantation 2022;43(4):228-234
Objective:To explore the effect and possible mechanism of normal temperature mechanical perfusion(NMP)plus bone marrow mesenchymal stem cells(BMMSCs)on early endoplasmic reticulum stress(ERs)and cellular apoptosis after donation after cardiac death(DCD)donor liver transplantation.Methods:BMMSCs were isolated and cultured by adherence method.Sixty Sprague-Dawley(SD)rats were randomly divided into five groups of sham operation(sham), static cold storage(SCS), NMP, BMMSC and NMP plus BMMSCs(BP)( n=12 each). Liver tissue and serum sample of each group were harvested at Day 1/7 post-operation.Hematoxylin-eosin(HE)staining was employed for observing pathological changes of liver tissue; TdT-mediated dUTP nick end labeling(TUNNEL)staining for detecting cellular apoptosis; immunohistochemistry for detecting the expression of hepatocyte transcription factor C/EBP homologous protein(CHOP); Western blot for detecting the expressions of GRP-78, p-PERK, ATF4, CHOP and cleaved caspase-3. Results:Compared with SCS group, hepatic injury and inflammation significantly declined in NMP, BMMSC and BP groups and improvement of hepatic injury was the most pronounced in BP group.Cellular apoptosis lessened markedly in BP group at Day 1/7 as compared with SCS group and the difference was statistically significant.The expressions of ERs-related proteins GRP-78, p-PERK and ATF4 spiked in SCS group and the expressions of pro-apoptotic proteins CHOP and cleaved caspase-3 were significantly elevated and declined markedly in BP group.And the difference was statistically significant.Conclusions:BMMSCs plus NMP can significantly improve hepatocyte apoptosis and inflammatory response after DCD donor liver transplantation.And its mechanism may be correlated with suppressing early endoplasmic reticulum stress of hepatocytes.
10.Effect of Psychiatric Prevention and Therapy Program in the Community
Huan-rong LUO ; Xue-jing ZHANG ; Xiao-xuan DENG ; Shaoling XU ; Suping WU ; Yuansong ZHENG ; Dechun WU ; Qunming HUANG ; Jiantao LIU ; Juan XU ; Dahong QIU ; Yuexia LIU
Chinese Journal of Rehabilitation Theory and Practice 2006;12(3):190-191
ObjectiveTo analyze the outcome of psychiatric prevention and therapy program in the community in Huicheng District,Huizhou city.MethodsThe variables of supervision rate,improvement rate,society participation rate,disturbance creating rate of violence,the mean recurrence frequency in one year and hospitalization rate,etc.were observed in psychiatric patients pre-and post initiation of the program as the model of socialization,complexity,accessibility.Results3 years after carrying out the program in Huicheng District of Huizhou city,the supervision rate,improvement rate,society participation rate of psychiatric patients have significantly increased,and the disturbance creating rate of violence,the mean recurrence frequency in one year and hospitalization rate have substantially decreased.ConclusionThe psychiatric prevention and therapy program in the community in Huicheng District,Huizhou city has been shown to be an effective way for psychiatric intervention.