OBJECTIVE:To evaluate drug utilization of inpatients in neurology department of our hospital.METHODS:Category of drugs,consumption amount,consumption sum and administration time for each person of 853 cases in neurology department of our hospital in 2008 were analyzed retrospectively.RESULTS:Of total 853 inpatients,patients with stroke accounted for 82.8%.The first 3 drugs in the list of consumption amount were Nao'an capsule,folium ginkgo tablet and Shuxuetong injection.The first 3 drugs in the list of consumption sum were Shuxuetong injection,Monosialoganglioside injection and Cobamamide for injection.Aspirin tablet,Nao'an capsule and Cobamamide for injection took up the first 3 places in the list of DDDs.CONCLUSION:Inpatients in neurology department mainly suffer from cerebrovascular disease and are treated with TCM for activating blood and eliminating stasis and nervous system agents,They are also treated various complications such as infection,constipation,hypertension,diabetes and so on.Drug use in the clinic is rational.

OBJECTIVE:To make a systematic review on the efficacy and safety of canagliflozin in the treatment of type 2 dia-betes,and to provide evidence-based reference for clinical treatment. METHODS:Retrieved from Cochrane Library,PubMed,EM-Base,CBM and Wanfang database,randomized controlled trials (RCT) of canagliflozin (test group) versus placebo (control group)in the treatment of type 2 diabetes were collected,and Meta-analysis was performed by using Rev Man 5.2 statistical soft-ware after extracting data and evaluating quality. RESULTS:A total of 7 RCTs were included,involving 2 188 patients. The results of Meta analysis indicated that glycosylated hemoglobin levels [WMD=-0.82,95%CI(-0.99,-0.65),P<0.001],the proportion of HbA1c<7%[RR=2.51,95%CI(1.98,3.19),P<0.001],fasting plasma glucose levels [WMD=-32.91,95%CI(-39.65,-26.17), P<0.001] in test group were significantly better than those of control group,the incidence of genital tract infections was significant-ly higher than control group [RR=3.76,95%CI(2.23,6.35),P<0.001];however,compared with control group,there was no sig-nificant difference in the incidence of hypoglycemia [RR=1.13,95%CI(0.40,3.20),P=0.81] and urinary tract infections[RR=1.19,95%CI(0.82,1.73),P=0.36]. CONCLUSIONS:Canagliflozin is safe and effective in the treatment of type 2 diabetes,and it needs to be noticed with genital tract infections during the clinical use. Due to the limitation of methodology,large-scale and poly-centric RCT are required for further validation of the conclusions.

Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carbon Monoxide Poisoning ; enzymology ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Myocardium ; enzymology ; Young Adult

This aticle introduced the process of Botulinum toxin from toxin to drug, as well as the application in Spastic Cerebral Palsy such as dose, therapeutic estimation and side-effect etc.

This article discusses how to handle one or more block corruptions on an Oracle data file and describes some main methods for data extraction.

Objective To investigate the changes of microinflammatory indicators in the maintenance hemodialysis patients to provide the new idea for clinical treatment.Methods Serum super sensitive C reactive protein (hs-CRP),interleukin 6(IL-6),tumor necrosis factorα(TNF-α),homocysteine(Hcy),malondialdehyde(MDA),albumin(ALB),hemoglobin,transferrin(Tf)levels and in-tact parathyroid hormone(iPTH)levels in 80 patients with hemodialysis were detected and the results were compared with those in the normal healthy population.Results The hs-CRP,IL-6,TNF-αlevels in the maintenance hemodialysis patients were significantly higher than those in the normal healthy population (P <0.05 ),the CRP level was positively correlated with IL-6,TNF-α,Hcy, MDA and iPTH levels and negatively correlated with ALB and Tf levels.Conclusion The microinflammatory indicators in the ma-intenance hemodialysis patients are higher than those in the normal people,which urgently need to conduct the related treatment.

Objective To evaluate the clinical esthetical effect in the cervical margin of the porcelain fused to metal crown restoration.Methods 225 cases with the porcelain fused to metal crown were observed.The evaluator examined these restorations for cervical color,marginal fit,and gingival state.(Results 53) cases of restoration changed in the cervical color.The method and the tooth preparation volume,the procedure and the material,which were all closely relevant to the cervical color change.(Conclusion Using)the correct method,improving the procedure and choosing the proper material would reduce the cervical color change.

Epidemiological studies indicated that dietary tiber was inversely associated with stroke risk.Epidemiological studies have confirmed that increased dietary fiber intake can reduce the risk of stroke.Animal experiments and clinical studies have shown that dietary fiber intake may reduce the incidence of stroke by reducing vascular risk factors,such as hypertension,diabetes,dyslipidemia,and obesity.The direct mechanism of increased dietary fiber intake reducing stroke risk remains to be further studied.Clinicians should pay attention to the important role of dietary fiber,guide the patients with stroke and individuals at risk of stroke to increase consumption of fiber-rich fruits and vegetables.

BACKGROUND:Tissue engineering is an interdisciplinary field and its experimental safety covers a wide scope along with the increase in accidents of tissue engineering laboratories, the safety management in tissue engineering laboratories in universities has become an important public health problem. OBJECTIVE:To enhance the safety management strategies for tissue engineering laboratories in chinese universities and improve the safety management system. METHODS:PubMed, Elseveir, WanFang and CNKI databases were retrieved for the literatures concerning the biosafety, safety management of hazardous chemicals, waste, medical information, instrument operation and human body mechanics in tissue engineering laboratories, and then the status of laboratory management was analyzed. RESULTS AND CONCLUSION:The status of safety management in tissue engineering laboratories in China is analyzed based on the technique characters and regulations on safety management. Management strategies for laboratory safety have been proposed according to the differences in relevant laboratory safety management between China and the US, such as regular training on laboratory safety, improving the safety consciousness of experimental staff, constructing the strict system access to laboratory, improving safety facilities, standardizing the experimental safety manual and appointing specialized safety management committee. Comprehensive and systematical regulations on laboratory safety management will ensure the smooth running of tissue engineering laboratories in universities, thus accelerating the development of tissue engineering.

Objective To study the protective effect of a hyperoxic solution on phosgene-induced lung injury by observing the changes in W/D ratio, lung water (LW), and L/B, and MDA contents, GSH-PX activity, and protein contents in broncho-alveolar lavage fluid (BALF). Methods The rabbits were divided into normal control group, hyperoxic solution (HO) and balance salt(BS) groups.Group HO and Group BS inhaled phosgene, and hyperoxic solution was given intravenously in group HO, but BS was given in group BS. W/D, LW, L/B, and MDA contents,GSH-PX activity,protein contents in broncho-alveolar lavage fluid (BALF) were determined. Results The MDA contents, W/D, LW and L/B were increased, and GSH-PX activity was decreased significantly in Group HO and Group BS compared with control group (P