Adolescent ; Catheter Ablation ; methods ; Humans ; Male ; Pre-Excitation, Mahaim-Type ; Tachycardia, Atrioventricular Nodal Reentry ; surgery

The hypoxia-inducible factor-1(HIF-1) gene located on the long (q)arm 21-24 of chromosome 14, is composed of HIF-1? and HIF-1? subunits. HIF-1 promotes its target gene HRE to transcribe by binding to the element and then causes a series of responses of the cell to hypoxia. HIF-1 has been found to be overexpressed in breast cancer cell, and the expressions of HIF-1 level were correlated with the prognosis and prediction factors of breast cancer. As a cytokine, HIF-1 will be a new prognosis factor and a new target for the treatment of breast cancer.

78 min,HCT

Objective To evaluate the effects of modulated, medium frequency electrotherapy on hemodynamics after thoracic surgery to provide non-pharmacological measures for preventing deep vein thrombosis (DVT).Methods Seventy thoracic surgery patients were divided into an experimental group and a control group. Both groups received conventional treatment and nursing. The experimental group (35 patients) was treated with modulated, medium frequency electrotherapy additionally while the control group (35 patients) was not. The vein systolic maximum velocity (Vmax), vein diastolic minimum velocity (Vmin) and time-averaged mean velocity (TAVM) in the femoral vein, the superficial femoral vein, the deep femoral vein, the popliteal vein and the anterior tibial vein were observed before the operation, 4h after the operation, just after 20 minutes of electrotherapy, 15 min after the electrotherapy and 30 min after the electrotherapy. Results There were significant differences among the time points in the experimental group. There was no significant difference among the time points in the control group.There were significant differences in lower extremity hemodynamics between the experimental group and the control group at end of the electrotherapy session, but no significant differences at the later time points. Conclusions Modulated, medium frequency electrotherapy has a significant effect on lower extremity hemodynamics. It is an effective method for DVT prophylaxis in perioperative thoracic surgical patients.

Acupuncture Points ; Acupuncture Therapy ; Adult ; Aged ; Eye ; physiopathology ; Female ; Humans ; Male ; Middle Aged ; Paralysis ; physiopathology ; therapy ; Trochlear Nerve Diseases ; physiopathology ; therapy ; Young Adult

OBJECTIVEThis study aims to determine the awareness oral medical interns about occupation safety protection of knowledge and to present a scientific basis for perfecting the occupation safety education system and standard protection behavior.

METHODSA self-designed questionnaire that used a retrospective questionnaire survey on 425 stomatological interns, scoring, and statistical analysis of the survey were performed. The questionnaire included occupation safety prevention knowledge, behavior cognitive, and protective behavior, among others.

RESULTSThe questionnaire recovery rate was 100%, and the average scores of the prevention knowledge and behavior cognitive were 4.55 ± 0.91 and 4.40 ± 1.05, respectively. More than 90% interns can conduct the conventional protection, and less than 40% can perform special protection. For the item "occupation safety protection knowledge", the scores of three grade III hospitals were higher than that of stomatological hospitals and second level of first-class hospitals; the difference was statistically significant (P < 0.001). For the items "behavior cognition" and "protective behavior", the scores of the second level of first-class hospitals were lower than those of grade III hospitals and stomatolgical hospitals (P < 0.001). The second level of first-class hospitals was relatively poor in safety protection knowledge, behavioral cognitive, and protection behavior. The average score was higher for than for boys in the three contents, and the average score of interns accepting pre-job training was higher than those rejected; the difference was statistically significant (P < 0.001).

CONCLUSIONThe occupation safety knowledge of oral medical interns is not sufficient, and the protective behavior is poor. Schools and hospitals should strengthen the intern occupation safety and protection education and improve the status of occupation safety behavior.

Clinical Competence ; Humans ; Internship and Residency ; Occupational Health ; Occupations ; Oral Medicine ; education ; Retrospective Studies ; Surveys and Questionnaires ; Universities

Objective To investigate the clinical effect and survival quality of raltitrexed and radiotherapy in treatment of esophagus cancer. Methods 100 cases with esophagus cancer were selected. There were 50 cases using raltitrexed combined with concurrent radiotherapy as observation group. Others were treated with 5-Fu combined with concurrent radiotherapy as control group. The clinical therapeutic effect and survival situation of two groups were evaluated. Results After treatment, the total response rate of observation group (86.0%) was higher than control group (58.0%), the differences between the two groups was statistical difference(P<0.05).The one- and two-year survival rates in observation group were higher than control group (χ2 = 4.32, 7.954, P=0.038, 0.005<0.05).There was no significant difference between the two groups in incidence rate of acute esophagitis, acute bone marrow suppression and acute skin reaction. Conclusion The clinical therapy of raltitrexed plus radiotherapy in treatment of esophagus cancer is distinct, and improve the survival time and the quality of life of patients.

Objective To investigate the changes in pentane (marker of lipid pemxidation) concentuation in the expired air induced by hepatic ischemia-reperfusion(IR)injury in rabbits.Methods Thirty healthy male Japanese white rabbits weighing 2.4-3.0 kg Were randomly divided into 2 groups(n=15 each):group Ⅰ sham operation and group Ⅱ hepatic IR.Anesthesia was induced with 3% pentobarbital 30mg/kg iv and maintained with The animals were tracheostomized and mechanically ventilated.Femoral artery and vein were cannulated for BP monitoring and blood sampling.Hepatic blood flow was occluded for 25 min followed by 180 min reperfusion.The expired air was collected before(baseline,T0)and at 1,10 and 25 min of ischemia and at 1,10,25,60,120 and 180 rain of reperfusion (T1-9) for determination of pentane concentration which was extracted by solid phase micro-extraction (SPME) and detected by gas chromatography-mass spectrography(GC-MS).Blood samples were also taken at the above time points for measurement of serm ALT,AST and SOD activities and MDA concentration.The animals were killed at the end of 180 min reperfusion.Liver specimens were obtained for histology.Results There was no significant difference in age,body weight,MAP and HR between the two groups.There was no significant change in pentane concentration in the expired air and the ALT,AST and SOD activities and MDA concentration at all time points as compared with the baseline in sham operation group.In IR group the pentane concentration in the expired air was significantly increased at T4,5 and the ALT and AST activities and MDA concentration were significantly increased and SOD activity was significantly decreased at T7-9 as compared with the basehne and the sham operation group.Conclusion The pentane concentration in the expired air can reflect the occurrence of lipid peroxidation during hepatic IR injury.

【Objective】 To observe the effect of electroacupuncture(EA) onlearning and memoryin vascular dementia (VD) rats andto explore its possible therapeutic mechanism.【Methods】Fifty specific pathogenfree(SPF) adult rats were randomizedintofour groups.Except the 8 rats in the pseudo-operation group(group A),the other 42 rats were induced cerebral ischemia by four-vessel occlusion method.Then the model rats were randomized into model group (group B),EAgroup(group C) and nimotop group(group D).Groups Aand B were fed with the same forage and received no medication.Group Creceived EAonthe acupoints of Baihui,Geshu,Pishu and Shenshu,and EAwas set in continuous wave with the frequency being 150Hz,once per day and lasting 15 consecutive days.Group Dreceived nimotop 12mg/kg,qd,for 15 consecutive days.After 15-day treatment,the learning and memory abilities of the rats were observed by Morris water test,the plasma carbon monoxide(CO) level was detected by double-wavelength spectrophotometer,and brain nitric oxide(NO) content was examined byspectrophotometry-colorimetry.【Results】The model rats had obvious disorders of learningand memory,their escapelatency was prolonged,thetimes swimmingacross the platforminthe original quadrant did not differ fromthose inthe other three quadrants,and plasma COand cerebral NOlevels were obviouslyincreased.In EAgroup,escapelatency was shortened,thetimes swimmingacrossthe platform inthe original quadrant were more thanthose inthe other three quadrants,and plasma COand cerebral NOlevels were obviously decreased(P

Objective To characterize the skin physiology function of patients with ache and to facilitate its treatment. Methods Sixty patients with acne (20 males and 40 females) and 60 healthy human controls (20 males and 40 females) were included into this study. The average age of patients and controls was 23.4 years and 25.1 years, respectively. Sebumeter was used to detect the sebum secretion in the following areas: forehead, nose, right and left cheeks, Cutometer(R) MPA580 to measure the skin elasticity, and Scalar Moisture Checker to test the skin hydration on right and left cheeks. Results A significant increase was observed in the level of sebum secretion in the T-zones (199.98±58.21 μg/cm2 vs 117.55±63.16 μg/cm2, t=7.34, P<0.05) as well as in the cheeks(154.45±55.06 μg/cm2 vs 87.50±47.36 μg/cm2, t=7.14, P< 0.05) in the patients compared with the controls. However, the level of skin elasticity and hydration was of no significant difference between the patients and controls (0.7931±0.0755R vs 0.7882±0.0498R, 30.75%±3.87% vs 30.94%±2.91%, respectively, both P>0.05). Conclusion Facial sebum secretion is increased in patients with acne.