Objective To observe the effect and safety of modified Yishen Zhuyang Huoxue Huazhuo Formula for polycystic ovarian syndrome (PCOS) in the TCM pattern of deficiency of spleen and kidney with phlegm-dampness. Methods Totally 123 cases were recruited into this study and randomized to two groups by central random approach, 64 cases in the observation group and 59 cases in the control group. Patients in the observation group were given the modified Yishen Zhuyang Huoxue Huazhuo Formula, while those in the control group were given compound cyproterone acetate tablet, for two treatment courses, three months for one course. The changes of ovarian volume and the number of follicles before and after treatment were observed. Adverse reactions were also evaluated. Results Bilateral ovarian volumes in both groups decreased after treatment (P<0.05, P<0.01), while the control group showed a significant better improvement (P<0.05). The number of follicles in the two groups decreased, but no significant difference were observed between the two groups (P>0.05). The rate of adverse reaction in the observation group was lower than the control group. Conclusion Modified Yishen Zhuyang Huoxue Huazhuo Formula is effective for PCOS patient by reducing the ovarian volume with a low incidence of side effect.

Diabetic macular edema (DME) is thickening retina with two disc diameter,which is the leading cause of blindness in diabetic retinopathy patients.The initial studies demonstrated that laser treatment of DME prevented further visual deterioration but did not improve visual acuity.Although glucocorticoid slow-release system can extend the time of effective drug concentration,to help glucocorticoid better carry out its biological effect,further studies are needed to warrant their safety due to increasing intraocular pressure and cataract progression.Novel studies identifying the presence of vascular endothelial growth factor (VEGF) in the eye with DME allowed for the development of an alternative anti-VEGF therapy,which revolutionized the management of DME by not only preventing vision loss,but also improving overall vision.Anti-VEGF therapy is becoming the first-line treatment of DME.However,present treatment modalities including anti-VEGF for DME had limitations,which build on the current understanding of DME pathogenesis.Further in-depth study of the development and outcome of DME is needed to optimize the therapeutic schemes,based on objective and scientific observation of treatment response.Finally we need to fully utilize the public health services and clinical management resources for diabetic patients,to prevent the visual impairment of DME before its occurrence.

Pertussis is an severe infectious respiratory disease that continues to be a serious public health problem,which is caused by Bordetella Pertussis.Because it's highly infectivity,it is still an important etiological factor associated with persistent cough in adults and adolescents.With the introduction of mass vaccination in 1974,there has been a dramatic decrease in the morbidity and mortality.However,in recent years,increasing numbers of pertussis are reported in adolescents and adults in many countries where with high vaccination coverage.The thesis summarize and discuss the progress of pertussis cpidemiology and clinical characteristics.

Electromagnetic Fields ; adverse effects ; Health Policy ; Humans

Animals ; Dogs ; Drug Evaluation, Preclinical ; methods ; Statistics as Topic

Objective To observe the clinical cure effect of Zhilong Tongluo Decoction on chronic obstructive pulmonary disease in acute exacerbation(AECOPD). [Method] Take prospective research method to randomly divide 70 cases of AECOPD into 2 groups, the control one(35 cases) take routine western medicine(WM) for treatment, the treatment group(35), added with Zhilong Tongluo Decoction on the basis of control one. After being treated for 14d, compare their PH value, PaO2, PaCO2, HCT, ESR, CRP and clinical effect and side effects before and after treatment. [Result] The comparison of both groups had no difference of statistical meaning on PH,PaO2,PaCO2,HCT,ESR,CRP; after treatment, the PH and PaO 2 markedly increased, PaCO2 obviously decreased(P<0.05), so did HCT,ESR,CRP(P<0.05,P<0.01); the treatment group was much better than control one on improvement, so was the effective rate. Both had no marked side effects. [Conclusion] Zhilong Tongluo Decoction controls inflammation and improves ventilation and blood flow with its Tongluo(stretch col aterals), having obvious effect on AECOPD.

[Objective]To evaluate the application of sonographic measurements of the thickness of transverse carpal ligaments in CTS(carpal tunnel syndrome) patients.[Methods]Fifty-two wrists from 40 patients with CTS confirmed by surgery and 32 wrists from 20 healthy individuals(control group) underwent sonographic examination of the thickness of transverse carpal ligaments at the level of pisiform bone and the hook of the hamate bone in transverse plane by the same operator.[Results]The thickness of transverse carpal ligaments in CTS patients was(0.41?0.10) cm at hamate hook level and(0.35?0.11) cm at pisiform level versus(0.28?0.11) cm and(0.20?0.08) cm in the control group.There was significant difference in the mean value of thickness of transverse carpal ligaments hetween the two groups at the two levels.[Conclusion]Ultrasonography examination of the thickness of transverse carpal ligaments is a new and valuable technique in the diagnosis of carpal tunnel syndrome and is much helpful to choose operation methods.

Comprehensive evaluation for colleges of stomatology is a complex systematic engineering, which is affected by the determination of index and weight. Based on the previous research results,this study establishes a comprehensive evaluation index for colleges of stomatology in China by applying Delphi method,carrying out two-round consultation to 45 experts,which includes 4 first layer indicators and 21 second layer indicators.

Electromagnetic Fields ; adverse effects ; Humans ; Radiologic Health

Objective:To establish a system for quantitatively measuring alveolar bone density and to test its precision and validity. Methods: With the aid of computer technique, the system measured the average gray level intensity of regions of interest (ROIs) on standardized exposed direct digital periapical radiograph. To correct the variation resulting from exposure condition, an aluminum stepwedge was exposed simultaneously. By referring the image of aluminum stepwedge on each radiograph the equivalent aluminum thickness(EAT)and corrected gray level intensity(CGL)of the ROIs could be calculated as indicators of alveolar bone density. Nineteen specimens containing different amounts of hydroxy-phosphorite were radiographed. The precision of the system was tested by repeatedly measuring 2 of the specimens. The set of specimens was exposed under two different exposure time in order to test the system's validity to correct the gray level difference caused by different exposure time. Results: After repeated measurement of specimens, we found the Relative Standard Deviation(RSD) of EAT and CGL was between 0.83%-2.15%; At the level of 95%, if the difference of EAT between the two ROIs was larger than 0.05 mm or the difference of CGL was larger than 3, the content of hydroxy-phosphorite in them was different; The two sets of data during different exposure time were processed with Wilcoxon Signed Ranks Test, and the result showed effective correction of the variation caused by different exposure time. Conclusion:The precision and validity of the quantitative alveolar bone density measuring system are acceptable. The system can be used to compare alveolar bone density longitudinally and cross-sectionally.