The expression of matrix metalloproteinase-9 (MMP-9) after cerebral ischemia reperfusion injury can accelerate the damage of brain-blood barrier and plays an important role in brain edema after cerebral hemorrhage. The level of MMP-9 can reflex the severity of brain ischemia, indicate to the volume of infarct area and point out the prognosis of the disease. This article reviewed its source and expression,the gene regulation and polymorphism, hemorrhage transformation and nhibitors, and the mechanism was also analyzed.

ObjectiveTo explore the influence of slow and mild movements in Taichiquan kinesitherapy.MethodsForty healthy males were divided into Taichiquan group and walking group with 20 persons in each group. The shift of practicing a 5-min bout of the simplified Taichiquan exercise, time of walking 18 m at a comfortable pace and change of one person's body center of gravity during exercise were measured respectively.ResultsTaichiquan group had (1796.4±91)cm shift during 5 min Taichiquan exercise; walking group spent (14.1±1.7)s when walking 18 m at a comfortable pace; and the downward shift of body center of gravity due to the exercise style undulated ( 5.5 ±12.7)cm vertically below the umbilicus (P>0.05).ConclusionSlow, mild and continual movement is the kinesiological basis of Taichiquan kinesitherapy.

ObjectiveTo explore changes of the reacting force of the ankle joint (J) and the achilles tendon force (A) in the sagittal plane in a weight-bearing leg in a bout of the simplified-style Taijiquan exercise.MethodsJ and A determined from 30 healthy young males were analyzed using the simplified free body method.ResultsJ and A increased during exercise, J produced by movement 10, 14 and A produced by movement 8, 12 were about 2.4 times and 0.7 times body weight of 67.3kg respectively.ConclusionTaijiquan can increase the force of ligment and muscle around the ankle joint, especially that of triceps muscle of calf, and it is helpful for remaining the stability of the ankle structure.

ObjectiveTo explore the change of the concentration of monoamine neurotransmitters in serum in patients with post stroke depression(PSD).Methods85 patients with acute stroke were screened by Center for Epidemiological Survey,Depression Scale(CES-D) and assessed by Hamilton Depression Scale(HAMD).A clinical diagnostic of depression was made based on Diagnostic and Statistical Mannal of Mental Disorders,edition 4(DSM-Ⅳ).There were 34 patients who involved with depression(PSD group), the others(51 cases) not(no depression group).Other 20 normal persons were chosen as a control(control group). In all patients and control subjects, the concentrations of monoamine neurotransmitters in serum was measured.ResultsThe concentration of monoamine neurotransmitters in serum was significantly lower in patients with post stroke depression.ConclusionsPost stroke depression is related to decrease of concentrations of monoamine neurotransmitters in serum.

The article sums up "the brain and the heart both govern the spirit"from the ancient philosophical basis,ancient anatomy,living and medical practice,the development of TCM viscera picture theory and modern clinical application of the corresponding theories.

The recent literatures showed that the acupuncture therapy had played a special role in treating ischemic stroke, including the changes of fibrinolysis, amino acid neurotransmitters, active peptides, proteins in the blood, calmodulin, nitric oxide and the synthase, and so on. But the standard of judgments, the manipulations of acupuncture, the selection of acupoints, and the course of treatment remain uncertain.

Overexpression of epidermal growth factor receptor (EGFR) in esophageal cancer has been related to tumor grade, vascular invasion and metastasis. The level of EGFR expression may be a predictive marker of esophageal caneer's sensitivity to chemoradiotherapy. EGFR inhibitors have been indicated as an effective targeted therapy, and promising results have been observed in phase Ⅱ and Ⅲ clinical trials.

Thirty-four patients with chronic lingual tonsillar hypertrophy were treated in our department from 1994 to 2000. There were 18 males and 16 females ranging in age from 21 to 60 years old. The clinical feature of lingual tonsillar hypertrophy usually appeared a series of pharyngeal symptoms, such as foreign-body sensation, sore throat, speech change, difficulty in swallowing, dysapnea and obstructive sleep apnea. The CO2 laser surgical lingual tonsillectomy was used for these patients. Result showed that the cure rate was 100% without any serious complications by following up 2 months to 3 years. The variety of presentations of lingual tonsillar hypertrophy and methods of surgical treament were discussed.

Objective To investigate the risk factors of vagus nerve invasion of advanced adenocarcinoma of esophagogastric junction (AEG).Methods The specimens from 98 patients with advanced AEG who underwent radical total gastrectomy and esophagogastric Roux-en-Y anastomosis from January 2011 to August 2012 at the First Affiliated Hospital of Anhui Medical University were collected.Serial section cutting was done and the upper and bottom incisional edges of every section were marked.The specimens were stained by hematoxylin-eosin solution,S-100 and CK immunohistochemistry.Vagus nerve invasion could be affirmed if cancer cells were observed in the peripheral space of vagus nerve and vagus nerve parenchyma or cancer cells infiltrated along the peripheral space of vagus nerve.Relationship between nerve invasion and clinicopathological factors was analyzed using chi-square test or Fisher exact probability.Factors related to vagus nerve invasion were analyzed using one-way analysis of variance and multi-factor logistic regression analysis.Results The incidence of vagus nerve invasion was 28.6％ (28/98),and the tumor only invaded the vagus nerve which had the same altitude as the upper incisional edge.The results of one-way analysis of variance showed that Siewert classification,intravascular cancer emboli,lymph node metastasis,the degree of lymph node metastasis,clinical staging,the degree of tumor differentiation were correlated with the vagus nerve invasion (x2 =14.156,14.552,5.454,10.706,6.919,14.767,P ＜ 0.05).The results of multi-factor logistic regression analysis showed that Siewert classification,intravascular cancer emboli and degree of tumor differentiation were the independent influencing factors of vague nerve invasion (OR =3.667,10.368,0.249,P ＜ 0.05).Conclusion Vagus nerve invasion is correlated with Siewert classification,intravascular cancer emboli and degree of tumor differentiation.The range of vagus nerve invasion is restricted under the upper incisional edge of tumor section.

As the third generation platinum antitumor drug with independent intellectual property rights,a number of basic and clinical research shows lobaplatin can effectively inhibit the proliferation of human breast cancer cell lines including triple-negative breast cancer in vivo.Compared with the cisplatinbased regimens,lobaplatin-based regimens have similar efficacy,and better safety profile.It becomes the new treatment option of metastatic breast cancer,and remains to be further study to optimize clinical rational drug use.