Epithelium ; pathology ; Humans ; Melanoma ; pathology ; Skin Neoplasms ; pathology

Objective: To explore the relationship between thyroid hormone levels and prolonged recovery after cardiac surgery with cardiopulmonary bypass (CPB) in congenital heart disease (CHD) children younger than 1 year of age. Methods: A total of 186 CHD children younger than 1 year treated in our hospital from 2014-01 to 2015-01 were retrospectively summarized. According to the pediatric intensive care unit (PICU) stay time, the patients were divided into 2 groups: Prolonged recovery group, the patients stated in PICU≥5 days,n=39 and Non-prolonged recovery group, the patients stayed in PICU<5 days,n=147. Thyroid hormone levels within 24 hours of operation with prolonged recovery conditions were studied. Results: Compared with Non-prolonged recovery group, the patients in Prolonged recovery group showed decreased levels of FT3 (2.02 ± 0.48) pg/ml vs (2.27 ± 0.46) pg/ml, TT3 (0.59 ± 0.30) ng/dl vs (0.71 ± 0.24) ng/dl and TT4 (5.39 ± 2.58)μg/ml vs (6.49 ± 2.20) μg/ml, allP<0.05; while the levels of free thyroid hormone and thyrotropin were similar between 2 groups,P>0.05. Multivariable logistical regression analysis presented that low level of FT3 within 24 hours of operation was the independent risk factor for prolonged recovery (OR= 0.32, 95% CI 0.12-0.84,P=0.02); linear regression analysis indicated that post-operative reduction of thyroid hormone was related to low body weight of the patients (r=0.11,P<0.001). Conclusion: Lower body weight was usually having lower level of FT3 within 24 hours of operation, which was the independent predictor for prolonged recovery in CHD children younger than 1 year after cardiac surgery.