Objective To explore the influence of follow-up by telephone on adherence and quality of life for breast cancer patients with hormonal therapy.Methods Totally 78 breast cancer patients with hormonal therapy were divided into the intervention group (40 cases) and the control group (38 cases).The control group were carried on routine guidance treatment and enjoined regular subsequent visit.The patients in intervention group were carried on the above-mentioned treatment and also receive regular follow-up by telephone.Through the follow-up by telephone we provided guidance for present and will present problems.Adherence for breast cancer patients with hormonal therapy and cancer rehabilitation evaluation system-short form(CARES-SF) were used to investigate the patients' adherence and quality of life six month after the intervention.Then we compared the adherence and quality of life before,six month of the intervention.The changes of adherence and quality of life scores were analyzed by repeated-measure ANOVA.Results The score of quality of life in the intervention group after 6 month of intervention was (25.43 ± 6.04),while in the control group was (40.61 ± 7.73),the difference was significant between the two groups,P＜0.05.The score of medication adherence in the intervention group after 6 month of intervention was (8.57 ± 6.20),while in the control group was (14.12 ± 6.63),the difference was significant between the two groups,P＜0.05.Conclusion Follow-up by telephone can improve adherence and quality of life for breast cancer patients with hormonal therapy.

With the development of mass spectrometry technology and its wide range of applications in the biological field,Veristrat classifier has been applied in non-small cell lung cancer (NSCLC) individualized therapy as well as in other tumors.Oncologists select individualized treatment plan based on peripheral blood veristrat test results.Many trials have verified its guiding role in NSCLC and other tumors' s first line and multi-line individualized therapy.Veristrat classifier provides a new idea and method for individualized treatment of NSCLC and other tumors.

0.05). Conclusion Both sulfurous acid,magenta and acetylacetone spectrophotometric methods were suitable for the determination of formaldehyde in rongalite in the laboratory of basic units, and acetylacetone spectrophotometric method was better because less environmental factors interfered with the detection results.

Objective To compare and investigate the criteria of impairment evaluation about eye injury.MethodsThe distill items, contents of these items and excursus of three criteria, Assessment and Gradation of Disability Caused by Work-related Injuries and Occupational Diseases (AGDCWIOD), Assessment for Body Impairment of the Injured in Road Traffic Accident (ABIIRTA) and Assessment and Gradation of Impairment Caused by Trauma (AGICT), commonly used in justice practice at present were compared.ResultsThere were essential differences among three criteria. AGDCWIOD was loose, ABIIRTA and AGICT were strict. AGDCWIOD and AGICT were religious, ABOIIRTA was oversight and non-religious. At the same time, there were differences between domestic and international criteria, and domestic criteria were behind the times.ConclusionThere are many problems in the criteria of impairment evaluation about eye injury; related items need recension and consummation.

Fish bones are the most common pharyngeal foreign bodies encountered in the ENT emergency. Many fish bones may be buried in the surrounding soft tissue of the pharynx and larynx. Any delayed treatment for these foreign bodies may cause catastrophic complications. We present a case of 51-year-old woman who had an ingested fish bone migrating to the retropharyngeal space. We used spiral Computed tomography scanning (CT, taken at intervals of 2mm) with dimensional reconstruction for the accurate location diagnosis and surgical planning. We treated successfully before any complication by transoral Laser CO2 microsurgery.
Animals ; Female ; Foreign Bodies ; surgery ; Humans ; Laser Therapy ; Microsurgery ; Middle Aged ; Pharynx ; surgery ; Seafood ; Tomography, Spiral Computed ; Tomography, X-Ray Computed

Stereotactic body radiation therapy (SBRT) has been applied in extracranial metastases effectively,with the characteristics of concentrated dose distribution in target region,great dose gradient change in surrounding region and low dose in normal tissue beside target region.The radiation biology characteristics of SBRT,therapeutic mechanism,integration of SBRT into standard systemic therapy regimens have been studied further.

[Summary] Osteoporosis in elderly women are commonly accompanied by elevated levels of ferritin. Abnormal iron metabolism plays a key role in the progress of osteoporosis. Research on bone metabolic disorders caused by iron accumulation remains at the exploratory stage, including NF-κB pathway in differentiation of osteoclasts. A review on the relationship between NF-κB pathway and osteoporosis induced by iron accumulation is herewith presented, with a view to provide further ideas for transforming the clinical outcomes.

BACKGROUND:According to the previous studies, it is known that bone marrow mesenchymal stem cells live in the physiological environment of lower oxygen concentration compared with the common culture concentration (20%-21%). Hypoxia can promote bone marrow mesenchymal stem cells proliferation and maintain the characteristics of differentiation potential.
OBJECTIVE:To understand the biological characteristics of bone marrow mesenchymal stem cells after hypoxic preconditioning, and search for in vitro basis for bone marrow mesenchymal stem cells therapy in vivo with hypoxic preconditioning strategy.
METHODS:After passage and inoculation, bone marrow mesenchymal stem cells were cultured in the hypoxic incubator (1%O2, 5%CO2). Bone marrow mesenchymal stem cells cultured in the normoxic incubator (20%O2, 5%CO2) served as controls.
RESULTS AND CONCLUSION:Compared with bone marrow mesenchymal stem cells cultured under normoxia (20%O2), bone marrow mesenchymal stem cells cultured under hypoxia (1%O2) began to display exponential growth phase after a longer incubation period. Hypoxia (1%O2) was not the lethal condition for bone marrow mesenchymal stem cells. cellsurvival rates of both groups reduced over time, while those of bone marrow mesenchymal stem cells cultured under normoxia reduced faster (P<0.05). Surface markers expression of bone marrow mesenchymal stem cells, including CD29(+), CD90(+), CD31(-), CD45(-), after hypoxic preconditioning did not change greatly when compared with the results before hypoxic preconditioning. The hypoxia preconditioned bone marrow mesenchymal stem cells did not differentiate into vascular endothelial cells. Hypoxia-inducible factor-1αprotein expression was promoted after 24 hours to 48 hours hypoxic preconditioning, and there was significant difference between the two time points (P<0.05). Vascular endothelial growth factor expression increased at both transcriptional and protein levels after 48 hours hypoxic preconditioning (P<0.05). Culture under hypoxia (1%O2) does not produce a lethal effect on bone marrow mesenchymal stem cells and can be used for hypoxic preconditioning. Surface markers of bone marrow mesenchymal stem cells after 48 hours hypoxic preconditioning exhibit no great changes and the hypoxia preconditioned bone marrow mesenchymal stem cells maintain the characteristics of stemness. Hypoxic preconditioning can promote the ability of bone marrow mesenchymal stem cells to survive under hypoxia/ischemic condition. The activation of the hypoxic response signal transduction pathway through hypoxia-inducible factor-1αmay explain this.

To study the curative effect of selective posterior rhizotomy for spastic limbs after spinal cord injury, and to study the histochemistry of nerve roots. The posterior nerve roots of L 2～S 1 were separated from anterion roots and splited into rootlets. The lower threshold rootlets were sectioned after electrical stimulation. The sectioned rootlets were studied with histochemistry. The resalt showed that the selective posterior rhizotomy was performed on 29 cases who were followed up for 3 years. The treatment was satisfactory. The rate of reducing spasticity was 90% and the rate of functional improvement was 80%. The Ache reaction of sectioned rootlets was positive. The result suggest that it is a successful way to treat spastic limbs after spinal cord injury with selective posterior rhizotomy. Electrical stimulation is necessary in selective posterior rhizotomy.