OBJECTIVE:To observe the clinical efficacy and safety of Guizhi fuling capsule combined with Tamoxifen citrate tablet in the treatment of breast hyperplasia. METHODS:216 female patients with breast hyperplasia were randomly divided into control group and observation group. Control group was orally treated with Tamoxifen citrate tablet 10 mg,bid. Observation group was additionally orally treated with Guizhi fuling capsule 3 granules,tid. The treatment course was 3 months. Drug withdrawal was conducted in menstrual period. The clinic data was observed,including clinical efficacy,the maximum mass diameter and breast pain scores before and after treatment,and incidence of adverse reactions. RESULTS:The total effective rate in observation group was significantly higher than control group,the difference was statistically significant(P<0.05). After treatment,the maximum mass diameter and breast pain scores in 2 groups were significantly lower than before,and observation group was lower than con-trol group,the difference was statistically significant(P<0.05). There was no significant difference in the incidence of adverse reac-tions(P>0.05). CONCLUSIONS:Guizhi fuling capsule combined with Tamoxifen citrate tablet has more significant efficacy than only Tamoxifen citrate tablet in the treatment of breast hyperplasia,with similar safety.

BACKGROUND; Studying the pathogenesis and rule of intestinal barrier damage under exercise stress will provide theoretical evidence for preparing intestinal barrier protectant under this state.OBJECTIVE : To observe the changes in intestinal barrier of rats following different intensities of swimming exercise. DESIGN: Randomized controlled animal experiment.SETTING: Laboratory of Exercise Sciences & Sports Medicine, Huibei University; Basic Laboratory, Medical College, Wuhan University.MATERIALS: Thirty-six healthy male SD rats, aged 3 weeks, were involved and randomized into 3 groups: control group (n =10), proper exercise group (n =12) and excessive exercise group (n =14). The rats of three groups were raised in the same condition.METHODS:①Control group: Rats did not exercise normally. ②Proper exercise group: Rats swam without loading. In the first 3 days, they adaptatively swam for 30 minutes and gradually for 60 minutes within 1 week, then they swam once a day, 6 times a week, 6 weeks in total. ③Excessive exercise group: In the first 3 days, they adaptatively swam for 30 minutes and gradually for 120 minutes within 1 week. After trained for 1 week, they were given excessive swimming training. Then, they were forced to swan once a day, 6 times a week, within 4 weeks successively. Within later 2 weeks, the rats were forced to swan once in the morning and evening separately, 6 times a week.MAIN OUTCOME MEASURES:①Intestinal barrier parameter: intestinal mucosal permeability, plasma endotoxin, becterium shift rate.②Intestinal mucosal membrane structure.RESULTS: Thirty-six rats were involved in final analysis.①After excessive exercise, plasma endotoxin of rats was doubly increased, intestinal mucosal permeability was enhanced by 2.5 times, and bacterium shift rate was increased by 230%.②Proper exercise had no obvious influences on the structure of intestinal mucosal membrane tissue of rats, and excessive exercise expanded Golgi complex in the intestinal epithelial cells and rough endoplasmic reticulum of rats, caused severe edema of epithelial cells and infiltration of inflammatory cells.CONCLUSION: Proper exercise improves intestinal function of body; excessive exercise causes intestinal barrier injury of body and pathological syndrome of digestive system.

Pancreatic fistula is a common complication after pancreaticoduodenectomy(PD),and other complications occurred secondary to it such as hemorrhage and severe abdominal infection are also the main cause of death after PD.Proper selection of anastomotic methods is essential to the success of PD.The most common anastomotic methods can be divided into pancreaticojejunostomy and pancreatogastrostomy,but the effects of these methods have always been controversial consistently.In this paper,the effects of pancreaticojejunostomy and pancreatogastrostomy in the prevention of postoperative pancreatic fistula were synthetically analyzed based on recent research results.

Acupuncture Points ; Acupuncture Therapy ; Adult ; Chronic Disease ; therapy ; Defecation ; Diarrhea ; physiopathology ; therapy ; Humans ; Male

Acupuncture Points ; Acupuncture Therapy ; Adult ; Female ; Humans ; Infertility, Female ; therapy

Acupuncture Therapy ; Adult ; Female ; Fever ; complications ; Humans ; Neuralgia ; etiology ; therapy

Acupuncture Points ; Acupuncture Therapy ; Edema ; pathology ; therapy ; Humans ; Lower Extremity ; pathology ; Male ; Middle Aged

Acupuncture Therapy ; Adult ; Dysmenorrhea ; complications ; Female ; Humans ; Syncope ; etiology ; therapy

Acupuncture Points ; Acupuncture Therapy ; Humans ; Male ; Meniere Disease ; therapy ; Middle Aged ; Treatment Outcome

Objective To study the relationship between neural apoptosis and the expression of Bcl-2,Bax proteins in the perihematomal brain tissue of patients with intracerebral hemorrhage(ICH).Methods The rate of neural apoptosis of perihematomal brain tissue was examined by TUNEL method and the Bcl-2,Bax proteins expression were detected by immunohistochemisty method. Correlation analysis was done not only for the expression of Bcl-2,Bax proteins and apoptosis rate with hematoma volume but also for the apoptosis rate with hematoma volume, the scores of clinical nervous impairment and the course of disease.Results The apoptosis rate and the expression of Bcl-2,Bax proteins in the perihematomal brain tissue of ICH patients significantly increased in comparison with the control group (all P