The basic physical teaching is an important part of the training of students' scientific quality.For the advance of the teaching quality,we have to improve the traditional teaching pattern and the evaluation way of the physical quality.This paper offers a teaching method of in-depth dissemination for the basic physics and proposes an evaluation way of physical quality by the theory of attribute distinguishing.

Lipodystrophies represent a heterogeneous group of diseases characterized by varying degrees of body fat loss and predisposition to insulin resistance and metabolic complications such as diabetes mellitus,hypertrigly-ceridemia and hepatic steatosis. The lipodystrophies can be divided into generalized,partial or local,depending on the degree and locality of the observable fat loss;moreover,the generalized and partial divisions can be partitioned further into congenital or acquired forms. Until now,11 genetic factors including AGPAT2,BSCL2,CAVI,PTRF,PPARG, LMNA,ZMPSTE24,AKT2,CIDEC,PLINI and WRN were reported to be involved in congenital lipodystrophies. The most prevalent subtype of acquired lipodystrophy currently occurs with prolonged duration of protease inhibitor - contai-ning,highly - active antiretroviral therapy in human immunodeficiency virus(HIV)- infected patients. Other types of acquired lipodystrophies are mainly autoimmune in origin and display complement abnormalities. The current manage-ment includes cosmetic surgery and early identification and treatment of metabolic and other complications with diet, exercise,hypoglycemic drugs,and lipid - lowering agents. Metreleptin treatment demonstrated remarkable clinical effect and good tolerance.

Objective To investigate whether AZD1152 (AZD),the selective inhibitor of aurora kinase B,may play a role in the treatment of cisplatin-resistant ovarian carcinoma when administrated alone or in combination with cisplatin.Methods Hey (cisplatin-resistant ovarian cancer cell line) cells were analyzed.According to the treatment plan,Hey cells were divided into four groups (AZD group,cisplatin group,AZD + cisplatin group and control group).Methyl thiazolyl tetrazolium (MTT) assay was used to test the cells proliferation,caspase-3/7 activity analysis was used to analyze cells apoptosis,and fluorescence insitu hybridization (FISH) assay was used to determine the copy the number of chromosome 7 and checked the copy numbers of hTERC gene and C-myc gene.Results MTT test showed that proliferation of AZD group was lower than that in control group(P ＜ 0.01).The cells proliferation with the treatment with 10 and 20 nmol/L AZD for 24 hours was (81.4 ± 3.6)％ and (81.4 ± 3.6)％ respectively,and the cells proliferation for 48 hours was (43.1 ± 2.0) ％ and (38.5 ± 1.6) ％ respectively,which was significantly lower than control group (100％,P ＜ 0.01) ; Treated with the same concentration of AZD,inhibition of proliferation was significantly enhanced as the time extended (P ＜ 0.01).Proliferation in group AZD+cisplatin was lower than that in cisplatin group (P ＜ 0.01) which suggest that there were additive effects after combined AZD with cisplatin.Compared with control group,caspase-3/7 activity in AZD group increased significantly (P =0.000),and the same results was seen between AZD ± cisplatin group and cisplatin group or AZD group (all P ＜ 0.01).Compared with cisplatin group or control group,the copy numbers of hTERC,C-myc and the number of chromosome were significantly increased in AZD group and AZD + cisplat group (all P ＜ 0.05).Conclusions AZD could inhibite ovarian cancer cells proliferation and induce cells apoptosis significantly.AZD alone or in combination with cisplatin may result in the increased cells polyploidy.

Objective:To evaluate the clinical efficacy of left left atrial function for the healthy by using real-time three plane ultrasonic imaging in.Methods: The three plane real-time ultrasound imaging was used for evaluation healthy people of left atrial function in 32 adults (including storage volume of left atrium, left atrial pipeline volume, left ventricular ejection fraction). At the same time, the two-dimensional echocardiography was also used to detect the parameters which were to compare two methods of correlation and consistency.Results:Two methods of ultrasonic examination in LARV, LACV and LVEF indicators have no obvious difference; LARV, LACV and LAEF in three plane image and two-dimensional ultrasound images show good correlation, the correlation coefficient rLARV=0.82, rLACV=0.85, rLVEF=0.88,P<0.05).Conclusion:Real-time three plane ultrasound imaging and two-dimensional echocardiography in the assessment of left atrial function of normal people have a good correlation.

Objective To investigate the effects of icariin on the expressions of osteoprotegerin(OPG)and receptor activator of nuclear factor-kB ligand(RANKL)mRNA in rat osteoblasts cultured in vitro.Methods Calvarial osteoblasts were obtained from newborn SD rats aged＜24 h by trypsin-collagenase digestion method. After treatment with different concentrations of icariin(10~(-10)-10~(-4) mol/L)for 48 h,total RNA was isolated from osteoblasts.Expressions of OPG and RANKL mRNA were detected by semiquantitative RT-PCR.Results Icariin remarkably increased OPG mRNA levels and decreased RANKL mRNA levels in calvarial osteoblasts in a dose- dependent fasion with a maximum effect at a concentration of 10~(-7)mol/L(P＜0.05).Osteoblasts pre-treated with icariin prevented the inhibitory effect of dexamethasone on OPG mRNA(0.570?0.093 vs 1.083?0.081)and the stimulative effect on RANKL mRNA(1.079?0.050 vs 0.718?0.082)(both P＜0.05).Conclusion Icariin upregulates OPG expression and downregulates RANKL expression in osteoblasts,which may explain the beneficial role of icariin in preventing and treating osteoporosis.

Adult ; CD56 Antigen ; metabolism ; Carcinoma ; metabolism ; pathology ; surgery ; Carcinoma, Medullary ; pathology ; Carcinoma, Papillary ; metabolism ; pathology ; DNA-Binding Proteins ; metabolism ; Diagnosis, Differential ; Female ; Humans ; Paraganglioma ; metabolism ; pathology ; Thyroid Neoplasms ; metabolism ; pathology ; surgery ; Thyroidectomy ; methods ; Transcription Factors ; Triglycerides ; metabolism

Objective To establish the HPLC fingerprint of Taoren Xikang pills and provide the method for the quality control and evaluation of the preparation. Methods Methanol extracts of ten batches of Taoren Xikang pills were analyzed with HPLC-UV method. Analysis was performed on C18 column (4.6 mm× 250 mm, 5 μm) with the mobile phase of acetonitrile-water gradient eluted at the flow rate of 1.0 mL/min. The detection wavelength was 203 nm. Results A standard HPLC fingerprint procedure was developed for Taoren Xikang pills with 26 common peaks. The similarity of 10 batches of Taoren Xikang pills was not lower than 0.9. Conclusion The method is accurate, repeatable and can be used for the quality control of Taoren Xikang pills.

Objective The current status of achievement motive levels and autonomous learning ability of nursing students was studied and compared in order to put forward suggestions to improve the achievement motive levels accordingly.Methods 119 nursing students were investigated about their achievement motive levels and autonomous learning ability by questionnaires.Then these students were divided into three groups according to their achievement motive scores and the autonomous learning ability was compared.Results The scores of Success-oriented motive of nursing students were significantly higher than that of failure-threatened motive.The total score of autonomous learning ability was(88.653+9.373)and the autonomous learning ability among these three groups was statistically different(P＜0.01).Conclusion The achievement motive greatly influenced the autonomous learning ability of nursing students.Measures should be adopted to improve the achievement motives so as to enhance their autonomous learning ability.

Objective To investigate the curative effect and care measures using subhypothermia treatment in patients with severe brain injury.Methods 70 cases of severe brain injury were randomly divided into treatment group(n=35) and control group (n=35),the treatment with subhypothermia and correlation care,control group treated with conventional treatment care.Compared rate of cure,mortality and complications in two groups.Results In treatment group cured 30 cases ( 85.7% ),5 patients died (14.3% ),the control group cured 23 cases (65.7%),death 12 cases(34.3%).Two groups had significant difference (x2 = 4.15,x2 = 3.99,P ＜ 0.05 ).The GOS score (3.23 ±2.15) points in treatment group were lower than the control group(5.03 ±0.96) points after treatment(t =3.52,P ＜0.05).The incidence of complications in the treatment group was 17.0% (6/35) lower than the control group,37.1% (13/35 ) (x2= 3.95,P＜0.05).Conclusion Subhypothermia care may reduce complications in patients with severe brain injury.

Objective To study the method of internal boundary parameters identification of middle ear.Method The numerical model is created using CT technology.Based on Matlab tools,the neural network for identifying internal boundary is proposed.Result The uniform pressure of 105 dB is applied at the outside of the tympanic membrane,and the harmonic analysis is calculated on the model to take the training samples.The internal condition parameters are identified using the good neural network.Conclusions The investiga-tion shows that the inverse method reveals a fast convergence and a high degree of accuracy.