1.Graded nursing to rectal cancer patients with radioactive proctitis induced by preoperative neoadjuvant chemoradiotherapy
Suping GUO ; Xiuzhen LING ; Yijun DENG ; Yuanhong GAO
Modern Clinical Nursing 2014;(9):35-37
Objective To explore the key points of graded nursing care to rectal cancer patients with radioactive proctitis induced by preoperative neoadjuvant chemoradiotherapy.Methods The clinical data of 162 rectal cancer patients undergoing neoadjuvant chemoradiotherapy were analyzed retrospectively. The experience of grading nursing care for patients with radioactive proctitis induced by neoadjuvant chemoradiotherapy was summarized.Results Of 162 patients,radioactive proctitis occurred in 110 patients(67.9%).Among the 110 patients with proctitis,62(38.3%)were grade I radioactive proctitis,29(17.9%)gradeⅡand 19(11.7%)gradeⅢ.The graded nursing was done to the patients with radioactive proctitis and achieved good effect.Conclusions Radioactive proctitis has a high incidence in rectal cancer patients with preoperative neoadjuvant chemoradiotherapy and graded nursing care can reduce the distress of patients with radioactive proctitis effectively and promote wound healing,thus to improve their quality of life.
2.Analgesic and Anti-inflammatory Effects of the Water Extract of Glycosmis citrifolia (Willd.) Lindl
Lizhen HUANG ; Ningning HOU ; Wenfang MA ; Haijing WU ; Xiuzhen DENG ; Biao TANG
Herald of Medicine 2016;(3):233-236
Objective To observe the analgesic and anti-inflammatory effects of the water extract of Glycosmis citrifolia (Willd.) Lindl.on mice and explore the mechanism. Methods The analgesic and anti-inflammatory effects were evaluated by 0.7% acetic acid-induced writhing test,the hot plate test,tests of dimethylbenzene-induced ear swelling,1% carrageenan-induced paw edema,determination of PGE2 in inflammatory feet,0.6% acetic acid-induced increase in peritoneal capillary permeability and cotton ball granuloma. Results The water extract of Glycosmis citrifolia (Willd.) Lindl.at low,medium and high doses can reduce the acetic acid-induced writhing times (P<0.01 or P<0.05),increase the pain threshold of mice (P<0.01 or P<0.05), inhibit dimethylbenzene-induced ear swelling (P<0.01 or P<0.05),1% carrageenan-induced paw edema (P<0.01 or P<0.05) and PGE2 production (P<0.01),0.6% acetic acid-induced increase of peritoneal capillary permeability (P<0.05),and the de-velopment of cotton ball granuloma (P<0.01 or P<0.05). Conclusion The water extract of Glycosmis citrifolia (Willd.) Lindl.shows analgesic and anti-inflammatory effects on mice.
3.Effect of pulmonary surfactant on the incidence of bronchopulmonary dysplasia
Xiuzhen YE ; Jie YANG ; Jieling WU ; Qundi DENG ; Chuan NIE ; Wencheng LI ; Yue WANG
Chinese Journal of Emergency Medicine 2009;18(6):584-587
Objective To explore, the effect of different dosage of pulmonary surfactant (PS) on the inci-dence of bronchopulmanary dysplasia. Method Four hundred and three premature infants with hyaline membrane disease were divided into 3 groups according to the dose of PS: low-dose group (L-PS group, ≤ 100 mg/kg, n =188) ,high-dose group(H-PS group, > 100 mg/kg, n = 94) and no-PS group (N-PS group, n = 121). The frac-tional inspired oxygen(FiO2) and ptlmonary oxygenating function before and after 6 hours treatment were observed and the durations of oxygen therapy and mechanical ventilation, frequency of repeated intubafion, length of hospi-talization and the incidence of BPD were compared among the three groups. Results After 6 hours PS administra-tion, the FiO2,oxygen index and duration of oxygen therapy and mechanical ventilation were significantly decreased (P <0.05), while PO2 and the arterio-alveolar partial pressure of oxygen were significantly increased (P <0.05)in the H-PS and L-PS groups, compared with the N-PS group. Compared with the L-PS and N-PS groups,the H-PS group showed a decreased incidence of BPD. Conclusions PS administration could improve the pul-monary oxygenation and prevent the development of BPD, especially in high-dose.
4.The research about wet paking the ligustrazine phosphate to cure the effusion when using chemotherapy medicine
Xuejin ZHAO ; Yulan LI ; Yanhui ZENG ; Xiuzhen LIN ; Meiyin FENG ; Qunyu DENG
Chinese Journal of Practical Nursing 2006;0(26):-
Objective To study the effects of wet paking the ligustrazine phosphate to cure the effusion when using chemotherapy medicine. Methods Divided 120 patients into 2 groups randomly. In the experimental group, ligustrazine phosphate was used to cure the effusion, while in the control group, the traditional method was used. Compared the effects of differences between the two groups. Results The effects about curing the effusion in the experimental group was significant better than those of in the control group. Conclusion It is an effective method about wet packing the ligustrazine phosphate to cure the effusion when using chemotherapy medicine.
5.Study of dose distortion and Bragg peak location correction in MRI-guided proton therapy
Xiuzhen DENG ; Xiufang LI ; Mengya GUO ; Shuaizhe GU ; Qi LIU ; Zhiling CHEN
Chinese Journal of Radiation Oncology 2022;31(2):176-181
Objective:To analyze the influence of magnetic field on the proton beam delivery and dose distribution, and develop a correction method for the Bragg peak (BP) shift under the vertical magnetic field, providing reference for the dose calculation and beam delivery of MRI-guided proton therapy.Methods:Monte Carlo (MC) simulation was used to study the dose distribution of the proton beam in the water phantom under the magnetic field. The BP location was corrected by the method of" angle correction+ energy correction" , and the correction parameters were calculated by the analytical formula based on the simulation data.Results:The magnetic field caused the dose distortion and shift of BP location. The shift degree was increased with the increase of field strength and initial energy. Compared with MC simulation, the result of calculating proton deflection in the air by the analytical method yielded a deviation within 0.2%. Based on the simulation data and calculation formulas, the correction parameters under different conditions could be calculated within 1 s by using the MATLAB programming. The calculation results showed that the air layer with magnetic field, isocenter depth, irradiation direction exerted different influence on the correction parameters. After correction, the BP location was basically consistent with the expected (offset ≤0.2 mm).Conclusions:The BP shift under the vertical magnetic field can be effectively corrected by " the angle correction+ energy correction" method. The correction parameters under different conditions can be quickly and accurately calculated by the calculation formulas based on simulation data.
6.The development and verification of an independent dose calculation toolkit for proton Therapy
Mengya GUO ; Xiufang LI ; Qi LIU ; Jie WANG ; Xiuzhen DENG ; Shuaizhe GU ; Yuehu PU ; Zhiling CHEN
Chinese Journal of Radiation Oncology 2022;31(10):910-915
Objective:To develop and validate the accuracy of an independent dose calculation toolkit for the horizontal beamline of Shanghai Advanced Proton Therapy (SAPT) facility based on an open-source dose calculation engine.Methods:Machine data, such as absolute integral depth doses (IDDs) and lateral profiles in air were measured and lateral profiles in water were derived by Monte-Carlo simulations. The dose computation models for SAPT horizontal beamline pencil beams in water were achieved by combining machine data and dose calculation engine. The verification of the dose reconstruction toolkit included absolute dose verification and relative dose verification. The absolute dose verification is performed to mainly compare the reconstructed value and the measured value at different depths along the center axis of the beam direction of a cube plan. The relative dose verification is conducted to mainly compare the lateral profile or two-dimensional dose distribution between the measured value and the reconstructed value. Meanwhile, the precision of double-gaussian and single-gaussian lateral beam models was compared.Results:The deviations of the absolute dose between the calculated and measured values were basically within 2%. The deviations of 20%-80% penumbra between the measured and the calculated values were within 1 mm, and deviations of the full width at half height were within 2 mm. For 3 cube plans and 2 clinical cases, the two-dimensional gamma pass rates (3 mm/3%) between the measured and calculated dose distributions at the corresponding depths were greater than 95%. The double-gaussian lateral beam model was more accurate in the high dose gradient region and deeper depth.Conclusion:The precision of independent dose calculation toolkit is acceptable for clinical requirements, which can be employed to investigate other dose-related issues.
7.Antimicrobial susceptibility surveillance in China: a MOHNARIN program report (2009-2010)
Yun LI ; Yuan LU ; Feng XUE ; Jian LIU ; Bo ZHENG ; Xiuzhen ZHANG ; Yunjian HU ; Ting YU ; Yunzhuo CHU ; Zhidong HU ; Jianhong ZHAO ; Shiyang PAN ; Wangsheng ZHAO ; Bijie HU ; Qiulian DENG ; Jian YANG ; Yan LI ; Wenen LIU ; Ling ZHOU ; Fang DONG ; Weiling FU ; Xiuli XU ; Fengyan PEI ; Ling MENG ; Ping JI ; Manning LI ; Weiwei YANG ; Jia ZHANG
Chinese Journal of Laboratory Medicine 2012;35(1):67-87
Objective To investigate the bacterial resistance in nationwide and understand the distribution of bacterial and resistance trend.MethodsThe 6507 clinical isolates were collected from 19 hospitals in 17 cities.The susceptibility tests were performed using agar dilution method recommended by Clinical and Laboratory Standards Institute (CLSI) in central laboratory.The values of MIC50,MIC90 and MICrange were calculated by SPSS 17.0 and the susceptibilities of isolates to antimicrobial agents were determined by using CLSI (2010) guideline.Of all 6507 isolates,4691 strains were collected from target wards and 1816 were isolated from others wards.ResultsAmong 4691 strains,1156 were Gram-positive (24.6% ) and 3535 were Gram-negative (75.4%).Based on the minimum inhibitory concentration results,the prevalence of methicillin resistant Stapylococcus aureus and methicillin resistant Stapylococcus epidermidis are 51.6% ( 325/630 ) and 87.0% ( 228/262 ) respectively.Staphylococci showing intermediate or full resistance to vancomycin were not observed. Coagulase negative Staphylococci showed 2.5% (16/642)intermediate rate and 1.6% ( 10/642 ) full resistance rate to teicoplanin,and showed 0.5% ( 3/642 )resistance rate to linezolid.Antibiotic resistance rate of Enterococcus faecalis to ampicillin was 17.1%(19/111),while the resistance rate of Enterococcus faecium to ampicillin reached up to 85.0%(164/193).Three Enterococcus faecium were resistant to glycopeptides.The prevalence of penicillin resistance Streptococcus pneumoniae and penicillin intermediate Streptococcus pneumoniae were 41.2% ( 145/352) and 37.2% (131/352) respectively based on oral penicillin criterion,while the prevalence were 0.0% (0/352) and 6.0%(21/352) based on vein to non-meningitis criterion.A vast majority of Enterobacteriaceae maintained high susceptibility to carbapenems,with resistance rate less than 2.0%.In addition,tigecycline,moxalactam,fosfomycin and amikacin displayed desirable antibacterial activity against Enterbacteriaceae,and resistance rates to these drugs were all less than 10.0%.For non-fermenting Gramnegative isolates,resistance rate of Pseudomonas aeruginosa and Acinetobacter baumannii to imipenem were 23.1% ( 139/601 ) and 53.5% (419/784) respectively.Resistance rate of Acinetobacter baumannii was much higher than that during the period 2007 - 2008.Colistin,tigecycline,minocycline and fosfomycin demonstrated good antibacterial activity against Acinetobacter baumannii in vitro.Conclusions Compared with MOHNARIN 2007 -2008year surveillance results, significant increase in resistance rate of Acinetobacter baumannii was demonstrated.Resistant strains to linezolid and tigecycline were found.Bacterial resistance has been a widespread problem in our country,which requires much more attention.
8. A multicenter clinical study on 1 138 cases of invasive pneumococcal disease in children from 2012 to 2017
Liang ZHU ; Wenhui LI ; Xinhong WANG ; Kun TAN ; Qingfeng FANG ; Qingxiong ZHU ; Kangkang WU ; Qiaozhi YANG ; Aiwei LIN ; Huiling DENG ; Jing BI ; Jing LIU ; Shiyong ZHAO ; Yun LIU ; Shujun JING ; Yumin WANG ; Lianmei LI ; Qing ZHAO ; Kaihu YAO ; Xi WANG ; Li JIA ; Fang WANG ; Jikui DENG ; Jing SUN ; Chunhui ZHU ; Kai ZHOU ; Jun LIANG ; Xiuzhen NIE ; Sancheng CAO ; Dongmeng WANG ; Shuangjie LI ; Xuexia CHEN ; Juan LI ; Yi WANG ; Lan YE ; Yanhong ZHANG ; Fang DONG ; Zhi LI ; Yonghong YANG ; Gang LIU
Chinese Journal of Pediatrics 2018;56(12):915-922
Objective:
To explore the clinical features, the serotype distribution and drug resistance of the isolates in patient with invasive pneumococcal disease (IPD).
Methods:
By retrieving the laboratory information system in 18 children′s hospitals from 2012 to 2017, the children with IPD were enrolled.
9.BRCA2 promoter polymorphism is associated with breast cancer prognosis in Chinese women.
Lu LIU ; Yi FANG ; Jianlin FAN ; Jianming HU ; Xiaoting XU ; Xiaohong JIN ; Xiuzhen WANG ; Min DENG ; Jing WANG ; Wei LIU
Chinese Medical Journal 2014;127(11):2012-2015
BACKGROUNDBreast cancer 2 (BRCA2) is an important breast cancer-susceptibility gene. Promoter polymorphisms in BRCA2 may affect its transcription and be associated with cancer prognosis.
METHODSWe identified five polymorphisms of the BRCA2 promoter region by in silico searching and direct sequencing: -254A/G (rs3092989), -908A/G (rs206117), -1134A/G (rs206115), -1144C/T (rs206116), and -1260CTTAGA/- (rs3072036). The -908A/G, -1134A/G, -1144C/T, and -1260CTTAGA/- polymorphisms were genotyped by direct sequencing in 491 breast cancer patients, and the -254A/G polymorphism was genotyped by Sequenom.
RESULTSThe -1144C/T polymorphism was associated with clinical outcome. Carriers of the TT genotype had longer disease-free intervals (DFIs, P = 0.029), especially among patients with sporadic unilateral breast cancer (P = 0.010). Linkage disequilibrium (LD) analysis showed that all the five single nucleotide polymorphisms (SNPs) were in LD (D' > 0.8). Carriers of haplotypes containing the -1144T allele showed longer DFIs (P = 0.049), and the result was more significant in patients with sporadic unilateral cancer (P = 0.018). There were no significant associations between the other polymorphisms and DFI.
CONCLUSIONSThe results of this study suggest that homozygosity for the BRCA2 T(-1144) allele is associated with a longer DFI in Chinese women with breast cancer. Further functional studies are warranted to clarify this relationship.
Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group ; genetics ; Breast Neoplasms ; genetics ; pathology ; Female ; Genetic Predisposition to Disease ; genetics ; Genotype ; Haplotypes ; Humans ; Linkage Disequilibrium ; Middle Aged ; Polymorphism, Single Nucleotide ; genetics ; Promoter Regions, Genetic ; genetics