Objective: To investigate the short-term effects of ischemic preconditioning (IP) on left ventricular diastolic function in diabetic patients with acute myocardial infarction(AMI). Methods: Totally 188 patients with first AMI were studied. Eighty-one patients without diabetes were divided into group A (with IP) and group B (without IP). The other 107 patients with diabetes were divided into group C (with IP) and group D (without IP).The effect of IP on peak creatine kinase value and left ventricular diastolic function were analyzed separately. Results: The peak creatine kinase value, the peak creatine kinase MB fractions and the incidence of E/A

Objective To observe the action of lowering blood fat of corn filament beverage(CFB) on hyperlipemia rats and mice.Methods Sixty rats were randomly divided into control group,alloxan model group,kanglishu capsule 0.70 g?kg-1 group,CFB 7.00,3.50,1.75 mL?kg-1 groups(n=10).Rats in each group were exhibited once a day for 21 d,on the seventh day,fourteenth day,twenty-first day, the contents of serum total cholesterol(TCHO) and triglyceride(TG) were determined,and liver malonaldehyde(MDA) level was measured.Another 60 mice were divided into 6 groups with the method mentioned above,mice in each group were exhibited once a day for 14 d,on the fourteenth day,the serum contents of TCHO and TG were determined,and liver MDA level was determined.Another 72 mice were randomly divided into control group,egg yolk model group,Expellant and Cleanning Fat Capsule 0.4 g?kg1 group,CFB 10.0,5.0,2.5 mL?kg-1 groups(n=12).Mice in each group were exhibited once a day for 10 d.16 h before the last administration,except control group,the mice in other groups were injected with 75% yolk physiological salt solution 0.5mL through the abdominal cavity,and began to starve,1 h after the last administration, the contents of serum TCHO and TG were determined,and liver MDA level was measured.Results Compared with alloxan model group,TCHO and TG in hyperlipemia rats of CFB 7.00 mL?kg-1 all reduced obviously(P

The changes of the hemorheology, plasma cholesterol and albumin and clinicaleffects in 36 children with refractory nephrosis after treatment with polysaccharide sulfate (PSS) were observed. The results showed that the indices of hemorheology and the plasma cholesterol decreased obviously and the albumin increased obviously than the control group ( P

Objective To investigate changes of markers of prethrombotic state(PTS)with heart failure and to explore their clinical significances.Methods Plasma levels of t-PA、PAI-1、Fg、PT、APTT、ET-1、MPV were measured in 52 patients with heart failure and in 38 normal controls.Results Compared with the healthy control group,patients with heart failure had significant increase of plasma PAI-1、Fg and ET-1level.Conclusions PTS is present in heart failure,especially in those with more severe Nyha class.

Objective To determine serum soluble interleukin 2 receptor level in patients with posthepatitis B liver cirrhosis.Methods Serum sIL 2R was measured using enzyme linked immunosorbent assay.Results Serum sIL 2R was significantly higher in patients with posthepatitis B cirrhosis than that in controls(P

Objective To investigate the effects of treatment of syphilis in pregnancy on perinatal prognosis. Methods Patients of syphilis in pregnancy from Hainan Provincial People′s Hospital and Haikou Municipal Maternal and Child Health Center during 1995.1 to 2001.1 were collected for retrospective analysis. Pregnant women with syphilis were divided into treated group and untreated group according to whether they received penicillin anti syphilis treatment or not during pregnancy. Results The total number of deliveries in the 2 hospitals during that period was 18 701, and 61 out of 9 805 women screened for syphilis were positive, giving an incidence of 6 2/1000. The perinatal mortality rates were 11 2% in treated group and 83 3% in untreated group, and incidences of congenital syphilis were 17 6% and 72 7% respectively. Conclusion Syphilis in pregnancy is a serious complication to harm the fetus. Screening of syphilis during pregnancy is necessary, and penicillin treatment is effective which may reduce the perinatal mortality rate and the birth of congenital syphilis baby.

Objective:To investigate the expression of CD28 costimulatory molecule on human lymphocytes inhibited by siRNA.Methods:Three different siRNA (siRNA 1,siRNA 2,siRNA 3) were designed and synthysized and transfected into freshly isolated human lymphocytes with cationic liposome.At 24,48 and 72 h post transfection,the changes of CD28 expression were detected by flow cytometry,and the changes of CD28 mRNA levels were determined by semi quantitative RT PCR.Results:Different siRNA showed different reduction in CD28 expression.At 48 h post transfection,the degrees of reduction with siRNA 1,siRNA 2 and siRNA 3 were 22 10%?1 63%,73 50%?1 02% and 42 90%?0 89% respectively compared with the control ( P

Objective To explore ihe physiological changes of the late-onset depressive(LOD) persons during sleep.Methods 15 cases of LOD patients formed a group and 10 healthy aging persons formed a control group.Hamilton Depression Scale (HAMD) was used to score the severity of depression and polysomnographic recorders were used to monitor the whole night long.The subjective feelings of the sleep and the daytime mental status were assessed in the morning.Results Compared with the controlde group, the LOD patients obviously possessed a disordered sleeping process: sleep efficiency was lower( ( 59.20 ± 2.90 ) %, ( 77.09 ± 1.55 ) %, P ＜0.01 ); their sleep latency was longer( (54.00 ± 4.97 ), ( 24.00 ± 2.91 ), P ＜ 0.01 ); the numbers of rapid eye movement(REM) sleep phase and rapid eye movement latency(REML) were strikingly different(P＜0.01 ).Compad with the control group, the LOD patients' awakening time and percent were significantly increased.Not only were the time and percentage of S2 sleep phase much higher, but the time of slow wave sleep was shorter.Besides,REM sleep activity, its density, and its intensity were raised (P ＜ 0.05 ).Conclusion There is a disturbance of the objective physiological indexes happening among the LOD patients.The increase of S2 sleeping time and percentage and the disinhibition of REM sleep can be used as the diagnosis indexes of LOD patients' specificity.

Objective To study the action of corn filament beverage (CFB)on falling blood sugar in diabetic rats and mice,provide scientific basis for application of corn filament extraction in falling sugar drug or functional food. Methods 60 rats were randomly divided into control group(pure water),alloxan model group,Kanglishu capsule (0.7 g?kg-1) group,and 7.00,3.50,1.75 mL?kg-1 CFB groups(n=10). the orbital vein blood samples were obtained,the contents of blood sugar were determined;The liver samples were obtained and the contents of liver glycogen were determined. 72 mice were randomly divided into control group(pure water),alloxan model group,Kanglishu capsule (1.0 g?kg-1) group,and 10.0,5.0,0.25 mL?kg-1 CFB groups(n=12),the indexes mentioned above were determined.72 mice were divided into 6 groups same as the method mentioned above,the mice were injected adrenalin hydrochloride through abdominal cavity,blood was extracted by decapitation,and the contents of blood sugar and liver glycogen were determined. Another 72 mice were divided and fed same as the method mentioned above,and the mice were injected glucose through caudal vein,the indexes mentioned above were detected. Results Compared with diabetic model rats,the contents of blood sugar in 7.00 and 3.50 mL?kg-1 CFB groups were reduced obviously(P

Objective To make a systematic review of pressure ulcers risk factors in critically ill patients. Methods We systematically reviewed all articles related to the pressure ulcers risk factors in critically ill patients. The Cochrane Library, PubMed, EMBASE, Web of Science Core Collection, CNKI, WANFANG and SinoMed were searched to August 2016. Results In total, 13 eligible articles were included. These studies included 18, 184 critically ill patients, six studies were classified as high quality, and seven were classified as moderate quality. Risk factors for the development of pressure ulcers include age, ICU stay, diabetes, mean arterial pressure<60-70 mmHg (1 mmHg=0.133 kPa), mechanical ventilation and mechanical ventilation, drugs, sedation and postural changes. Conclusions There is no single factor that can explain the occurrence of pressure ulcers. So it is in a variety of factors interaction, the occurrence of a significant increase in risk.