Through the review of the research on electronic health records at home and abroad,the author introduced the process of the construction of electronic health records at home and abroad.By comparing the reviews,we sumed up the characteristics of the construction of the electronic health records abroad,so as to provide references to our electronic health records and improvement suggestions for insufficient health records construction in China.

OBJECTIVE:To evaluate the cost-effectiveness of 3 kinds of traditional Chinese medicinal injections in the treatment of angina pectoris caused by coronary heart disease(CHD).METHODS:223 CHD patients with angina pectoris were divided into 3 groups:group A(Xuesaitong injection),group B(Breviscapine for injection) and group C(Shuxuening injection). The curative effects were observed and the cost-effectiveness analyses of the 3 groups were conducted as well.RESULTS:The costs for the 3 groups were 1 345.50 yuan,1 768.125 yuan,1 770.00 yuan,respectively; the total effective rates were 83.75%,82.09% and 85.53%,respectively; the cost-effectiveness ratios were 16.07,21.54 and 20.69,respectively;the incremental cost-effectiveness ratios of group B and C were 254.60 and 238.48,respectively as against group A. CONCLUSION:Xuesaitong injection(group A) is the preferred therapy for angina pectoris caused by CHD.

Papers on big data studies in domestic libraries were analyzed with g index and cluster analysis method with CNKI as the data source,which showed the following hotspots in studies on big data,namely innovative service, subject service and literature resource development , big data storage , big data process , big data mining and analy-sis, big data processing technology and tools.The problems waiting to be solved were pointed out.

Objective To explore the application of transanal drainage tube in decompression of acute left- sided colorectum obstruction and its nursing. Methods Twenty- one cases of patients, with acute left-sided colorectal obstruction, were enrolled in this study from 2011 and 2014, Results Of the 21 cases, 5 failed to drip, 6 was difficult to drain, 2 having loose stools around the anus, 2 with the tubes out of the anus, and 6 with obstructed tubes during the drainage. Nineteen finally underwent surgery, 16 of which with 1- stage operation, and 13 of the 16 with sufficient lymph node dissection, without stoma leakage. Conclusions Transanal drainage tube plays an important part in acute left- sided colorectal obstruction, and a professional nursing work could help maintain the unobstruction of the tube, which is of much importance in the procedure of the drainage and the decompression of the obstruction.

Objective To determine the effect of interleukin (IL)-17 on the proliferation of fibroblastlike synoviocytes (FLSs) from rheumatoid arthritis (RA)patients and to investigate whether signal transducer and activator of transcription 3 (STAT3) was implicated in this process.Methods FLSs were acquired by primary culturing from RA patients.STAT3,p-STAT3,Bcl-2 and Bax expression in FLSs were determined using western blotting analysis.The proliferation of FLSs was determined by MTT assay.Analysis of variance was used to determine the differences between two groups.Results IL-17 promoted the proliferation of FLSs from RA patients and inhibited their apoptosis.The pro-apoptotic Bax was decreased and anti-apoptotic Bcl-2 was increased in FLSs from RA (t=2.612,P＜0.05;t=2.723,P＜0.05).However,targeted silencing of STAT3 could inhibit the effect of IL-17 on FLSs (t=2.745,P＜0.05).[the control group:Bax (3.814±1.623),Bcl-2 (1.429± 0.311);IL-17 group:Bax (0.972±0.017),Bcl-2 (3.175±1.356);STAT3 silent group:Bax (5.729±1.236),Bcl-2 (0.637±0.006)].Conclusion STAT3 is critical in IL-17-induced proliferation of FLS from RA patients.IL-17/STAT3 pathway might be a good candidate for RA treatment modalities.

Objective To explore the character and clinical value of high frequency ultrasound in diagnosing abdominal wall endometriomas .Methods The characteristics of the ultrosonographic images in 32 cases with abdomi-nal wall endometriomas by operation and pathology were analyzed retrospectively .Results A total of 33 lesions, including 1 case of multiple (2 lesions),the rest of the 31 cases were single,mostly in the original abdominal incision place or incision side subcutaneous soft tissue ,1 case away from the incision ,located in the inguinal region .26 lesions was located in the subcutaneous fat and 6 lesion in the rectus abdominis muscle .All of the lesions hadn't capsule and were irregular in shape .The internal echo behaved low echo and on homogenous mostly ,one or more small anechoic lacunae could be seen on sonography .CDFI according to Adler semi -quantitative method classification ,25 lesions was 0 level (no blood flow signal),7 lesions for I level (edge had a small amount of pitting,short rod blood flow signal),Pulse doppler performance for low -speed and high-resistance characteristics.Conclusion Combining with the history and clinical performance , high frequency ultrasonography in abdominal wall endometriosis can be made relatively clear diagnosis,surgery of positioning has a guiding significance ,which can be used as the disease choice examination method.

Objective To analyze the relevant factors of vaginal delivery postpartum hemorrhage,and discussion how to prevent postpartum hemorrhage.Methods 2 417 maternal women who hospitalized vaginal delivery were selected.Preeclampsia,macrosomia,placental abruption,obesity,premature rupture of membranes,high blood pressure,gestational age,maternal age,maternal time,the number of abortion,scar uterus vaginal delivery,oxytocin induced labor,misoprostol for cervical mature,forceps midwifery,and the correlation of postpartum hemorrhage were analyzed.Results The incidence rate of postpartum hemorrhage was 15.22%.Pre -eciampsia,macrosomia,placental abruption had significant association with postpartum hemorrhage(χ2 =26.75,0.16,22.26,all P <0.01).Obesity, premature rupture of membranes were associated with postpartum hemorrhage(χ2 =6.53,4.98,all P <0.05).High blood pressure,gestational age,maternal age,maternal time,the number of abortion,scar uterus vaginal delivery had no statistical correlation with postpartum hemorrhage (P >0.05 ).Oxytocin induced labor,misoprostol for cervical mature,forceps midwifery were significantly associated with postpartum hemorrhage(χ2 =45.66,21.77,88.06,all P <0.01 ).Conclusion Prenatal maternal and neonatal weight control,prevention of preeclampsia,placental abruption occurred to prevent postpartum hemorrhage;Intrapartum avoid no indications oxytocin,misoprostol for cervical mature,forceps midwifery and reduce postpartum hemorrhage;Postpartum accurately estimated blood loss, active treatment,avoid serious complications.

Objective To evaluate the feasibility and efficacy of the ultrasonic technology,digital subtraction angiography(DSA) combined guide line of liver abscess drainage tube.Methods 70 patients with liver abscess received ultrasonic technology,DSA joint drainage tube after treatment.Using ultrasound technology and DSA of complementary advantages,enhancement in the operation was good,especially the liver abscess of abdominal pneumatosis was more and more room,enhancement effect was better than that of pure guided by ultrasound.Results 70 patients were all successful puncture and catheter,development was good,all 70 cases cured,without any serious complication.Conclusion Ultrasound technology,DSA joint guided puncture catheter drainage is a safe,minimally invasive treatment,has significant efficacy and important clinical value.

A breakthrough has recently been made in the studies on pathogenesis of HIV disease,which result in some new theories.New strategies for HIV drug and vaccine development are emerging in the impact of these new understandings.The intestinal infection hypothesis proposes that HIV disease can be regarded as some kind of infectious disease of gut immune system as the major HIV infection is located in intestine.The acute catastrophe hypothesis suggests that the subsequent pathological changes are the fallout from a mucosal catastrophe of acute intestinal HIV infection,in which the majority of CD4+ T cells are deleted due to infection.The general immune overactivation hypothesis proposes that the general immune overactivation is harmful to patient as it increases the cell susceptibility to HIV infection and supportiveness of HIV replication.The host proteins related to HIV replication can be new targets for HIV drug discovery.The mucosal vaccine strategies,which attempt to induce HIV specific neutralizing antibodies on mucosal surface may be the first choice in development of prophylactic HIV vaccines.Induction of tolerance may be one of the strategies for HIV therapeutic vaccines because HIV disease can be regarded as autoimmune disease caused by HIV infection.

AIM: The aim of the present study is to explore the effects and mechanisms of HIV-1 glycoprotein gp120 on calcium-influx and ERK-phosphorylation of human microglia.METHODS: The level of intracellular calcium of human microglia grown on coverslip,which was loaded by calcium-probe,Fluo-4,and then treated in various experimental processing,was detected by confocal microscopy with time resolution mode.The binding of gp120 to human microglia was determined with confocal microscopy or flow cytometry after treatment with gp120 and stained with anti-gp120-FITC antibody.Phosphorylation of ERK within human microglia with or without gp120 stimulation was analyzed with confocal microscopy following the direct immuno-staining with anti-phosphorylated ERK antibody.RESULTS: The results of confocal microscopy showed that calcium-influx response was triggered by HIV-1 glycoprotein gp120 in human microglia.The results from analysis by confocal microscopy and flow cytometry showed that gp120 was able to bind to human microglia.ERK phosphorylation was enhanced in human microglia stimulated with gp120.CONCLUSION: HIV-1 glycoprotein gp120 induces calcium-influx in human microglia and enhances ERK phosphorylation in human microglia,indicating that gp120 is an activator of human microglia.So gp120 may be involved in the pathogenesis of HIV-associated dementia.