Objective To explore the TCM syndrome and its distribution regularity of premature ovarian failure(POF) as well as the relation between the etiological factor and TCM syndrome of it.Methods The pathogenetic condition and etiological factor of 122 patients with POF were surveyed,and TCM syndrome differentiation was carried out on them.Results The TCM symptoms of POF manifested the tendency of variety.Among the 122 cases,Gan-stagnation and Shen-deficiency type accounted for 33.61% of them,Gan-Shen yin deficiency type for 18.03%,Pi-Shen yang deficiency type for 15.57%,Jin damage due to excessive heat type for 15.57%,Shen-deficiency blood stasis type for 8.20%,and Gan-stagnation and Pi-deficiency type for 7.38%.The influence of modern living environment and life style to the disease was found in 68.03% of the patients’ case history.31.15% of the patients was induced by emotion,31.97% by drugs and disease,and 4.92% by both of them.In patients induced by emotion,the proportion of Gan-stagnation and Shen-deficiency type was the highest as compared with the other types(P0.05).Conclusion Gan-stagnation and Shen-deficiency type,Gan-Shen yin deficiency,Pi-Shen yang deficiency type and Jin damage due to excessive heat are the commonly encountered syndromes in patients with POF.Besides the congenital,Shen-Qi and Chong-Ren Qi-blood insufficiency as well as the genetic factor,the modern living environment and life style have the promotion in the genesis of POF.

Objective To observe the effect of the modified Yulin Decoction on improving the living quality of patients with yang-deficiency of the spleen and kidney of premature ovarian failure. Methods One hundred and twenty-seven patients were divided into experimental group (80) and control group (47) by non-randomized noninferiority comparative study. The experimental group was treated with modified Yulin Decoction daily orally once a day. The control group was treated with oral estradiol valerate and progesterone cycle. Two groups received continuous medication for 21 d, and treatment interval was 5 d. Three cycles of treatment were set as one course, and treated for 2 courses. The SF-36 scale was used to calculate the total scores and scores of eight dimensions before and after treatment. Results Before treatment, there was no significant difference (P>0.05) in the scores of SF-36 dimensions (except somatic pain) and total score between the two groups. Compared with before treatment, the score and total score of SF-36 in the experimental group increased (P<0.05, P<0.01). The mental health score of the control group was higher than that of before treatment (P<0.05, P<0.01). After treatment, there was statistical significance in the two dimensions of vitality and mental health in the two groups (P<0.05). There were significant differences (P<0.01) in the total score and scores of SF-36 physiological function, physical pain, general health, vigor, social function, emotional function and mental health between the two groups. Conclusion Modified Yulin Decoction can improve the living quality of patients with yang-deficiency of the spleen and kidney of premature ovarian failure.

Perimenopausal syndrome （MPS）， a common endocrine system disease， is one of the diseases responding specifically to traditional Chinese medicine （TCM）. The China Association of Chinese Medicine organized experts in endocrinology， gynecology， and interdisciplinary fields of both Western and Chinese medicine to discuss the advantages and challenges of diagnosing and treating MPS with Western medicine， TCM， and integrative medicine. Experts at the conference believe that MPS is initiated by estrogen decline and rooted in deficiency， with the pathogenesis being imbalance between Yin and Yang in the kidney. The hormone replacement therapy in Western medicine for menopause can rapidly alleviate related symptoms by quickly restoring the estrogen level and timely detect and delay complications of menopause， whereas such a therapy has certain risks， necessitating close monitoring of adverse reactions. Moreover， the various contraindications and precautions limit the clinical application of the hormone replacement therapy. TCM has advantages in synergistically alleviating symptoms such as hot flashes， sweating， sleep disorders， and emotional abnormalities of MPS without causing obvious adverse reactions. However， its efficacy is slower than the hormone replacement therapy， and the TCM evidence for preventing and treating complications of menopause remains unclear. Three suggestions were proposed for the future development of both Western and TCM for ameliorating MPS. First， an integrated diagnosis and treatment system for MPS with both Western and Chinese medicine should be established. Second， high-quality evidence-based interventions for MPS should be developed with TCM alone or in combination with Western medicine. Third， efforts should be made to promote the new TCM drug development and the interdisciplinary cooperation for treating MPS.