Objective To study the application value of direct digital X‐ray radiography system in the degenerative lumbar insta‐bility .Methods 100 patients with degenerative lumbar instability disease were collected in our hospital ,in which there were L4 ,L5 (80 cases) and L5 ,S1 (20 cases) with degenerative lumbar instability disease .Carestream DRX‐Evolution system was used ,which included conventional horizontal lumbar function photography (control group) and physiological load of lumbar function photography (observation group) .Changes of the displacement or the angle of the lumbar segment on two groups were measured ,and the statisti‐cal software was used to carry on the comparative analysis .Results In 100 patients ,the position and the physiological load position were showed on the sagittal position which were as following :For the lumbar segment of L4 and L5 ,flexion [position (4 .50 ± 0 .25) mm , load position (4 .78 ± 0 .30) mm] ,extension [position (4 .87 ± 0 .22) mm ,load position (5 .18 ± 0 .30) mm] ,and for the lumbar segment of L5 and S1 ,flexion [position (4 .64 ± 0 .24) mm ,load position (4 .91 ± 0 .24) mm] ,extension [position (4 .95 ± 0 .30) mm , load position (5 .30 ± 0 .29) mm];For the intervertebral angle degree of L4 and L5 ,flexion (position 10 .64° ± 0 .29° ,load position 12 .12°± 0 .57°) ,extension (position 11 .57°± 0 .24° ,load position 12 .61°± 0 .28°);For the intervertebral angle degree of L5 and S1 , flexion (position 11 .63° ± 0 .26° ,load position 12 .72° ± 0 .27°) ,extension (position 13 .55° ± 0 .30° ,load position 14 .58° ± 0 .33°) , respectively .The difference between two groups was statistically significant (P< 0 .05) .Conclusion Compared with traditional method ,DR lumbar physiological weight‐bearing functional can more accurately understand the lumbar instability degree ,grading and lumbar positive rate ,which provides the basis for clinical diagnosis and treatment plan .

Objective To explore the association of epidermal growth factor receptor(EGFR)mutant non-small cell lung cancer(NSCLC)with tyrosine kinase inhibitor(TKI)-related rash based on network pharmacology and to predict the potential traditional Chinese medicine.Methods Gene chip data of EGFR mutant NSCLC cell lines and normal fibroblasts before and after treatment with erlotinib,a TKI,were collected from Gene Expression Omnibus database.Differentially expressed genes were screened using limma package of R 4.3.2 software.Cross-over target genes were screened using venn package.The differentially expressed genes and cross-over target genes were analyzed using ClusterProfiler package.CoreMine Medical database was used to predict traditional Chinese medicine of the cross-over target genes,and the nature,flavour,and channel tropism were analyzed.The results were verified by molecular docking method.Results A total of 126 cross-over target genes were screened.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses indicated that the differentially expressed genes and cross-over target genes were enriched in chromosome,spindle and other regions,and were involved in biological processes such as mitosis and DNA replication.These genes were also associated with signaling pathways including DNA replication,lysosomes,and cell cycle.Gene set enrichment analysis results showed that chemokine pathway and nucleotide-binding oligomerization domain-like receptor signaling pathway were activated in the NSCLC cells,and mammalian target of rapamycin signaling pathway and amino acid metabolic pathway were disturbed in the fibroblasts after treatment with erlotinib.CoreMine Medical database predicted that 354 kinds of traditional Chinese medicines were mainly classified as cold,warm and flat,bitter,pungent and sweet,belonging to stomach,lung and liver meridians.Taking Scutellaria baicalensis as an example,molecular docking analysis of experimentally validated target genes and their active components revealed strong binding interactions between the target genes and active components.Conclusion EGFR mutant NSCLC and TKI-related rash have homology in pathogenesis,both involving DNA replication and cell cycle,which provides traditional Chinese medicine medication instruction for patients with EGFR mutant NSCLC and TKI-related rash.