1.Application prospects of monitoring of brain function and diagnosis of brain injury in premature infants based on multimodal data
Chinese Journal of Applied Clinical Pediatrics 2017;32(14):1055-1057
It is critical to assess the development and injury of brain function in premature infants in early stage.Currently,brain development and brain injury are evaluated by many ways and mainly by kinds of imaging and behavioral neurological assessment.The integrated application of these examination methods have been explored for years.The combination of resting-state functional magnetic resonance imaging and electroencephalography has prominent advantages,because they do not need to perform specific tasks,and they are noninvasive and non-toxic for preterm infants.Based on the support vetor machine learning of artificial intelligence technology,the typical characteristics of 2 multimodal data can be integrated and a multimodal assessment system which automatically monitor and predict premature infants' brain function development and injury can be established.
2.Effect of fenofibrate and metformin on lipotoxicity in OLETF rat kidney
Wei WANG ; Xiaohui GUO ; Honghua WU ; Nianhong WANG ; Xiushuang XU
Journal of Peking University(Health Sciences) 2004;0(02):-
Objective:To explore the possible molecular mechanism of abnormal renal lipid metabolism in OLETF rats, and the effects of fenofibrate or metformin on renal local lipid metabolism. Methods: OLETF rats were randomly divided into three groups:one treated with fenofibrate, one with metformin and one without treatment. LETO rats were used as age-matched normal controls. The animals were sacrificed and the kidneys were obtained respectively at the age of 17 and 30 weeks. 24-hour urine albumin contents and TG contents in renal cortex were measured. The levels of SREBP-1 protein and mRNA in kidney were measured. FAS mRNA and ACC mRNA expressions were measured with RT-PCR. Results:OLETF rats showed characters of obesity, hyperglycemia, hyperlipidemia. At the end of thirty weeks clinical characters of renal damage appeared in OLETF rats, OLETF rats showed higher levels of 24-hour urine albumin contents than those of LETO rats. 24-hour urine albumin contents were correlated positively with TG contents in kidney. The partial correlation coefficient was 0. 870(P = 0.011) by controlling for body weight, serum lipid, blood glucose and fasting insulin concentration. OLETF rats showed higher levels of SREBP-1 protein (43. 2% , P
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