Because of the lack of professional knowledge guidance,in addition to the blind fear and eating disorders,leading to the incidence of hypertension in rural community of China was Showing an up-ward trend year by year.Hypertension was a chronic disease,was the potential risk factor for cardiovascular and cerebrovascular disease,severe heart,the function of brain,kidney and other important organ were fail-ure,to made people's life health and quality of life received threats.With the development of economy and society and the acceleration of the process of population aging,hypertension in the rural elderly population had became a common disease.,as a representative of non communicable chronic diseases,hypertension has seriously affected the normal development.Specification and strengthening the management of hyperten-sion in rural areas has become a hot topic,At present,mainly to the community as the main front for the prevention and treatment of hypertension.The traditional model of community hypertension management has gradually been eliminated.In recent years,China has carried out various aspects of community hypertension management model,In this study,we analyzed the community management of hypertension in rural areas in recent years,and made the following survey.

Neoadjuvant chemotherapy has become an indispensable weapon against high-risk resectable cancers, which benefits from tumor downstaging. However, the utility of chemotherapeutics alone as a neoadjuvant agent is incapable of generating durable therapeutic benefits to prevent postsurgical tumor metastasis and recurrence. Herein, a tactical nanomissile (TALE), equipped with a guidance system (PD-L1 monoclonal antibody), ammunition (mitoxantrone, Mit), and projectile bodies (tertiary amines modified azobenzene derivatives), is designed as a neoadjuvant chemo-immunotherapy setting, which aims at targeting tumor cells, and fast-releasing Mit owing to the intracellular azoreductase, thereby inducing immunogenic tumor cells death, and forming an in situ tumor vaccine containing damage-associated molecular patterns and multiple tumor antigen epitopes to mobilize the immune system. The formed in situ tumor vaccine can recruit and activate antigen-presenting cells, and ultimately increase the infiltration of CD8⁺ T cells while reversing the immunosuppression microenvironment. Moreover, this approach provokes a robust systemic immune response and immunological memory, as evidenced by preventing 83.3% of mice from postsurgical metastasis or recurrence in the B16-F10 tumor mouse model. Collectively, our results highlight the potential of TALE as a neoadjuvant chemo-immunotherapy paradigm that can not only debulk tumors but generate a long-term immunosurveillance to maximize the durable benefits of neoadjuvant chemotherapy.