OBJECTIVE:To carry out drug risk management so as to ensurethe safety of clinical drug use in the hospital. METHODS:The mode of drug risk management of our hospital was established,in the form of drug risk identification,risk evalu-ation,risk control and risk review,and the measures for risk management were developed and taken. The effect of drug risk man-agement was evaluated after 3 years (2012-2014) of colletion and analysis of the questionnaires given to clinical medical workers and patients and the results of evaluation by the group of pharmacy management and quality control for drug use in the hospital. RE-SULTS:Following the establishment and improvement of drug management information system,the strengthening of the manage-ment of special drugs,strict implementation of the Management System for the Return and Recall of Drugs,the establishment of specialized drug safety monitoring body,the development and implementation of the measures such as self-inspection in the hospi-tal,the problems about drug safety in our hospital had been decreasing from 2012 to 2014(88,42 and 19 cases respectively);and 96.59%,97.62% and 100% of drug safety problems were solved by the pharmacy staff to the satisfaction of the group of pharma-cy management and quality control for drug use in the hospital respectively in the three years. CONCLUSIONS:The mode of drug risk management established in our hospital has promoted the safety of drug use.