Objective: To study the effects of fortified conjugated linoleic acid (CLA) milk on body fat and plasma lipids in mice.Method:Forty male Kunming mice of 4 w old were randomly divided into four groups and fed diet and milk supplemented with 0%,0.1%,0.5%,1.0% CLA (percent of diet, dry mass) respectively for 4 w.Weight gain,body fat,intra-abdominal fat,feed conversion efficiency and plasma TG, TC, HDL , LPL were measured.Results:At the end of the experiment, all these physiological indices were decreased with increasing CLA in the milk and were lower significantly than that of control group when supplemented with 0.5% CLA in milk. TG , TC and (TC- HDL) / HDL were decreased, but HDL and LPL were increased with increasing CLA amount in the milk. TG,HDL,LPL and (TC- HDL)/ HDL were best when fed the milk supplemented with 1.0% CLA,while TC was the lowest when fed the milk supplemented with 0.5% CLA . Conclusion:The fortified conjugated linoleic acid is effective in lowering body fat and blood lipids.