Diffusion tensor imaging (DTI) can detect the integrity of white matter in vivo, through which various white matter damages of the brains have been found in patients with Alzheimer's disease (AD), even mild cognitive impairment. These damages of white matter may relate to the impairment of cognitive function, otherwise, damages in various area may result in various clinical features. DTI may fur-ther be used in the study of AD development and therapeutic evaluation.

Objective:To review the effect of kinesio taping on the lower limb function of stroke survivors.Methods:PubMed, Web of Science, Embase, the Cochrane Library, China′s National Knowledge Internet (CNKI), China Biology Medicine (CBM), Weipu Chinese Science and Technology Periodical Database and the WanFang Database were searched for reports of randomized and controlled trials (RCTs) testing the effect of kinesio taping on the lower limb function of stroke survivors published between January 1st, 2000 and October 1st, 2019. Two reviewers independently screened the reports, extracted data and assessed the risk of bias in the studies included. Version 5.3 of the RevMan software was used to analyze the extracted data.Results:A total of 13 RCTs involving 932 patients were included. Meta-analysis showed that the experimental group was significantly superior to the control group in terms of the improvement in walking speed and function, balance, fall risk, quadriceps strength, leg triceps strength, and general lower limb motor functioning. Their ability in the activities of daily living was also better on average as was their general life quality.Conclusions:Kinesio taping can improve stroke survivors′ balance, motor ability, muscle strength and life quality.

Objective To investigate the effect of acute or chronic administration of eseitalopram(ESC)on behavior of mice,which suffered from chronic unpredictable mild stress(CUMS).Methods Mice were exposured to CUMS for 8 weeks,then the behavior of mice were investigated every 2 weeks,and the effect of acute and chronic administration of escitalopram on behavior was compared.Results (1)The body weight of all stressed mice were lighter than control group(18.5±1.1)g from 2nd to 8th week(P＜0.01).After chronic administration of escitalopram,the body weight of cms+Cesc group(18.5±0.6)g were increased relative to other stressed groups(P＜0.01).(2)In open-field test for 15min,the total distance and central distance of stressed groups were further,and numbers of rear were more than control group(P＜0.05)from 2nd to 4th week,but then these indexes were decreased from 6th to 8th week(P＜0.05).After chronic administration,the total distance(57.4±11.0)m,central distance(12.0±3.0)m and numbers of rear(74.2±6.1)of cms+Cesc group increased(P＜0.05).(3)In sucrose preference test,the preference percentage of stressed groups was less than control group(P＜0.05)from 6th to 8th week at 8th week,the preference percentage of cms + Cesc group((79.0±2.7)%)was more than other stressed groups(P＜0.05).(4)In forced swimming test,compared with control group,immobility time of stressed groups became longer from 4th to 8th week..After chronic administration,immobility time of cms + Cesc group((124.7±8.00)s)was shorter than other stressed groups.(5)After acute administration,the behavior of cms + Aesc group was not different relative to pure stressed group(P＞0.05).Conclusion Chronic administration of escitalopram show up efficacy on depression behavior of CUMS mice,but acute administration is ineffective.

Objective To investigate the dose-respeuse relationship of levobupivacaine for spinal anesthesia in patients undergoing cesarean section.Methods Sixty ASA Ⅰ or Ⅱ patients aged 25-35 yr weighing 60-90 kg scheduled for elective cesarean section under spinal anesthesia were enrolled in this study.Spinal puncture was performed at the L3,4 interspace.A 25 G spinal needle was inserted into the subarachnoid space cephalad.The patients were randomized to receive levobupivacaine 7.5 mg (group L1 ),10 mg (group L2),12.5 mg (group L3) or 15 mg (group L4) diluted to 3 ml with 5% glucose over 30 s (n = 15 each).The degree of pain was evaluated at the time of skin incision using visual analogue scales (VAS) (0 = no pain and 10 = worse pain ever).Effective analgesia was defined as VAS = 0.Spinal analgesia was inadequate when VAS≥1 and then 1% lidocaine 5-10 ml was given epidurally.The doses of levobupivacaine for effective analgesia in 50% and 95% of patients ( ED50 and ED95 ) and 95 % confidence interval were calculated by Probit method.Results The ED50 of levobupivacaine was 9.0 mg (95% confidence interval 7.8-9.9 mg) and ED95 13.2 mg (95% confidence interval 11.6-17.6 mg) for spinal anesthesia.Conclusion The ED50 and ED95 of levobupivacaine for spinal anesthesia in patients undergoing cesarean section are 9.0 mg and 13.2 mg respectively.

Objective To investigate the effect of dexmedetomidine on agitation during recovery from sevoflurane anesthesia in children. Methods Three hundred ASA Ⅰ or Ⅱ children, aged 4-7 yr, weighing 16-30kg, scheduled for elective ear-nose-throat operation under general anesthesia, were randomly divided into 2 groups ( n = 150 each) : control group (group C) and dexmedetomidine group (group D) . Dexmedetomidine 0.5 μg/kg in 20 ml was infused intravenously over 10 min before anesthesia induction in group D, while equal volume of normal Saline was infused in group C. Anesthesia was induced with inhalation of 8 % sevoflurane 5 min after the end of administration . The children were tracheal incubated and mechanically ventilated. Anesthesia was maintained with inhalation of 2 % -3 % sevoflurane. BIS was maintained at 40-60 during operation. The recovery time and agitation within 2 h after operation were recorded. Results There was no significant difference in the recovery time between the two groups ( P > 0.05) . The incidence of agitation was significantly lower in group D than in group C ( P <0.05 ) . Conclusion Dexmedetomidine can reduce the occurrence of agitation during recovery from sevoflurane anesthesia in children.

This paper discussed the development history,study fields and course construction of medical informatics(MI) and compared the similarities and differences of MI between China and the other countries.

Objective To investigate the mechanism,clinical features of severe skin infection developed in the rehabilitation of the elderly diabetic patients and the commonly seen bacterium.Methods The causes of skin injury,the places of infection and bacterium were analyzed retrospectively.Meanwhile,chemical indicators on admission were analyzed.Results Skin injury was caused by the improper family care and the lake of self protection knowledge.The common places for infection were feet and then back and hip skin.Almost all the infections were caused by opportunists,among which staphylococcus was the most common one.The major separated risk factors were hypoalbuminemia,hyperglycemia,and high level fibrinogen and anemia.Conclusion The elderly diabetic patients are subject to skin infection.Diabetic education and careful nursing are the key to the prevention of severe skin infection.

Objective To evaluate the anti-human respiratory syncytial viurs ( hRSV ) effect of aminoglucomannan ( AGM) in mice.Methods BALB/c mice infected with hRSV were randomly divided into AGM and konjac glucomannan ( KGM) groups with 54 in each.Then, mice in AGM group and KGM group were subdivided into three groups and treated with different doses of AGM or KGM as 2.5 μmol/L, 0.25 μmol/L or 0.025μmol/L.Each subgroup was further divided into 3 groups with 6 in each according to administration intervals of AGM or KGM as 8 h, 12 h or 24 h.All the mice are sacrificed at 72 h.The general condition of the mice was observed everyday.Reverse transcription-polymerase chain reaction ( RT-PCR) was used to detect the expression of hRSV fusion protein ( F) mRNA in the lung tissue of the mice. HE staining method and immunohistochemistry technique for intercellular cell adhesion molecule-1 ( ICAM-1) expression in the lung tissue were used to evaluate the inflammation in the lung tissue.ANOVA for randomized block design was used to examine the influence of dose and administration intervals on the expressions of hRSV F mRNA and ICAM-1.Results Reduced activity and asthma were observed in 16 mice in the KGM group, but not in the AGM group.And two mice in the KGM group died at d3, but there was no death in the AGM group.RT-PCR showed that the levels of hRSV F mRNA in lung tissues were 0.49 ±0.21 in AGM group and 0.88 ±0.06 in KGM group (t=6.71, P<0.05).HE staining of lung tissue showed that the inflammation in KGM group was more serious than that in AGM group.The expression of ICAM-1 in AGM group was much lower than that in KGM group, and there was statistical difference between two groups (t=13.88, P<0.05).In AGM group, the levels of RSV F mRNA and ICAM-1 decreased with the increase of AGM’s concentration and rised with longer administration intervals (P<0.05), but these were not observed in KGM group (P>0.05).Conclusion AGM can alleviate the inflammation of lung tissue in mice infected with hRSV in a dose and time-depandent manner.

The paper quantizes symptom data through binary coding,divides 8 syndromes summed up by experts into excess and de-ficiency syndromes,values and quantizes them,and establishes the model for classification of excess and deficiency syndromes of colorec-tal cancer based on BP neural network and decision tree.The result shows that BP neural network classification model is more applicablefor the handling of the nonlinear mapping relation compared with decision tree classification model.

Objective:To explore the feasibility and safety of laparoscopic radical gastrectomy for gastric cancer through analysising the laparoscopic radical gastrectomy and open radical gastrectomy.Methods:Retrieval the Cochrane Library,PubMed,EMBASE,CBM,VIP,CNKI,WANFANG DATA,the time is from January 2010 to August 2015.Bring into the comparative studies about laparosopic radical gastrectomy and laparotomye.Processing data using the revman 5.2 to reaserch the feasibility and safety of laparoscopic radical gastrectomy.Results:7 clinical comparative studies were included in this study.The observation group was the group of laparoscopic radical gastrectomy and the control group was the group of laparotomye.Results showed that the length of incision of the observation group was shorter[MD=-12.93,95％ CI (-13.16,-12.70),P＜0.00001];The observation group bleeding was lesser[MD=-129.98,95％C1(-220.54,-39.42),P=0.005];The number of lymph node of the two groups had no significant difference [MD=0.77,95％ CI (-2.56,3.60),P=0.56];The operation time of the observation group was longer [MD=49.17,95％ CI (25.32,73.02),P＜0.0001];The hospitalization time of the observation group is shorter [MD=-2.27,95％ CI (-3.77,0.77),P=0.003].Conclusion:Laparoscopic radical gastrectomy is feasible and it is superior to laparotomye within the thoroughness,minimally invasiving and safety.