Objective To research and analyze the correlation of TNF-αexpression and renal damage in gestational hypertension patients.Methods 60 patients with gestational hypertension were selected as study group.Meanwhile,59 healthy pregnant women were selected as control group.The TNF-α expression and renal function were tested and analyzed.Results The TNF-α expression in study group was (24.7 ± 5.6)μg/L,(12.1 ± 8.2)μg/L in control group (P ＜ 0.05).The serum creatinine in 29 patients in the study group was (317 ± 24) μmol/L,TNF-α (26.9± 1.6)μg/L.The serum creatinine in other 31 patients was (153 ± 18)μmol/L,TNF-α (21.7 ± 2.1)μg/L.The serum creatinine in control group was (56 ± 19) μmol/L,TNF-α (10.3 ±4.1) μg/L.There was a positive correlation between TNF-α expression and serum creatinine.Conclusion The TNF-α expression may be positively correlate with renal damage in gestational hypertension patients.