1.Inhibitory effects of baicalein against herpes simplex virus type 1.
Zhuo LUO ; Xiu-Ping KUANG ; Qing-Qing ZHOU ; Chang-Yu YAN ; Wen LI ; Hai-Biao GONG ; Hiroshi KURIHARA ; Wei-Xi LI ; Yi-Fang LI ; Rong-Rong HE
Acta Pharmaceutica Sinica B 2020;10(12):2323-2338
Herpes simplex virus type 1 (HSV-1) is a ubiquitous and widespread human pathogen, which gives rise to a range of diseases, including cold sores, corneal blindness, and encephalitis. Currently, the use of nucleoside analogs, such as acyclovir and penciclovir, in treating HSV-1 infection often presents limitation due to their side effects and low efficacy for drug-resistance strains. Therefore, new anti-herpetic drugs and strategies should be urgently developed. Here, we reported that baicalein, a naturally derived compound widely used in Asian countries, strongly inhibited HSV-1 replication in several models. Baicalein was effective against the replication of both HSV-1/F and HSV-1/Blue (an acyclovir-resistant strain)
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