3.Clinical observation of diabetic retinopathy after transplantation of autologous stem cell in diabetic patients
Xiao-Lin, HAO ; Xiu-Ling, YE ; Zhong-Chen, ZHANG
International Eye Science 2014;(9):1702-1704
To observe the effect of autologous stem cell transplantation in diabetic retinopathy.
●METHODS:Totally 58 cases (116 eyes) who underwent autologous stem cell transplantation were confirmed as no diabetic retinopathy (18 eyes), mild non-proliferative diabetic retinopathy (NPDR) (41 eyes), mid-level NPDR (51 eyes); severe NPDR (6 eyes) by ophthalmoscope directly or indirectly and fluorescence fundus angiography (FFA ). Follow - up was 6 - 12mo, the changes of retinopathy were observed.
●RESULTS: The total effective rate of vision and retinopathy was 84. 4%, 76. 7%. The results of severe NPDR was statistically worse than the other groups ( P <0. 05).
●CONCLUSlON: The stable blood glucose level and improved pancreatic function after autologous stem cell transplantation might be helpful in diabetic retinopathy, the long effects need to be researched further.
4.Effects of three different drying methods on extraction and separation of ginsenosides from fresh ginseng
Daijia ZHANG ; Zhilong XIU ; Xinhua LIN ; Dongjian QI
Journal of Integrative Medicine 2004;2(4):292-4
OBJECTIVE: There exists a close relationship between drying of a fresh herb and its preservation and extraction of efficient components. In order to investigate the influences of different drying methods on extraction and separation of ginsenosides, three drying processes, such as drying in the sun, drying in oven and microwave drying, were used to dry fresh ginsengs. METHODS: The ginsenosides of the dry ginsengs were extracted by poaching and microwave heating, and were separated by foam separation. The concentrations of ginsenosides were measured. RESULTS: Microwave drying saved both time and labor, and was favorable for release of ginsenosides. The ginsenosides could be extracted from the dry ginsengs in a shorter time by microwave heating than poaching. The ginsenosides Rb1, Rb2, Rd could be observably concentrated by foam separation. CONCLUSION: Microwave drying and microwave assisted extraction are efficient and economic methods with a high recovery yield of ginsenosides.
5.Measurements of interleukin-18 in peritoneal fluid and serum of patients with endometriosis.
Yi ZHANG ; Li-xiu PENG ; Lin MENG
Journal of Central South University(Medical Sciences) 2005;30(6):731-732
Adult
;
Ascitic Fluid
;
metabolism
;
Endometriosis
;
blood
;
metabolism
;
Female
;
Humans
;
Interleukin-18
;
analysis
;
blood
;
Middle Aged
6.Mechanism of protective effects of low dosage of ultrashortwave diathermy on cerebral ischemia-reperfusion injury
Li-Xin ZHANG ; Zhi-Qiang ZHANG ; Wei-Di LIANG ; Lin LI ; Xiu-Hua YUAN ;
Chinese Journal of Physical Medicine and Rehabilitation 2003;0(10):-
Objective To observe the effect of low dosage of uhrashortwave(USW) on infarction volume, B cell lymphocytoma-xl (Bcl-xl) and tumor necrosis factor alpha (TNF-?) after cerebral ischemia-reperfusion in rats and discuss its acting mechanisms. Methods Focal ischemia-reperfusion model was established in 25 rats by re- versible right middle cerebral artery occlusion with filament. The right side cerebral ischemia was lasted for 2 hours and then followed with 24 hours of reperfusion. The content of neurological deficits were evaluated by the Zea-Longa 5-degree scoring system to select rats. After surgery, the rats were divided into 3 groups: blank control group, control group and USW treatment group. The brain of all rats was taken at 24 hours after reperfusion. The cerebral infarction volume, the expression of Bcl-xl and TNF-?were measured and analyzed. Results Twenty-five rats were used in the analysis of results. When compared with the control group, the infarction volume and rate in total cerebral volume of USW group significantly decreased (t = 2.54, 2.33, P
7.Clinical characteristics of metastatic bacterial endophthalmitis in 22 cases
Hong-Bing, ZHANG ; Yan-Lin, ZHAO ; Jun-Jun, ZHANG ; Xiu-Ping, ZHU ; Tong, WANG
International Eye Science 2005;5(3):433-435
· AIM: To study the clinical characteristics of metastatic bacterial endophthalmitis.endophthalmitis were retrospectively studied.manifestation was found in 17 cases (77%), iridal purulent nodules in 2 cases and retinal purulent embolism In 3 cases. The total number of leucocytes and neutrophilic granulocytes was elevated markedly, while lymphocyte count was reduced significantly in early stage. Positive rate of bacterial cultivation was 36%.dophthalmitis often have apparent extraocular infected situation before eye Is involved. Ocular appearance and laboratory examination have some specificity in early stage, while bacterial cultivation, as a golden standard,needs to be further improved.
8.Rupture of primary splenic multilocular mucous cyst accompanied by pseudomyxoma peritonei: report of a case.
Wen QI ; Wen-xiu LIN ; Na DU ; Xiao WANG ; Li-yi GU ; Qian-xing ZHANG
Chinese Journal of Pathology 2013;42(2):129-130
Aged
;
CDX2 Transcription Factor
;
Cysts
;
metabolism
;
pathology
;
surgery
;
Diagnosis, Differential
;
Female
;
Homeodomain Proteins
;
metabolism
;
Humans
;
Keratin-20
;
metabolism
;
Mucous Membrane
;
pathology
;
Peritoneal Neoplasms
;
metabolism
;
pathology
;
surgery
;
Pseudomyxoma Peritonei
;
metabolism
;
pathology
;
surgery
;
Rupture
;
Splenic Neoplasms
;
metabolism
;
pathology
;
surgery
9.Preparation of budesonide sustained-release dry powder for inhalation and influence of lactose content.
Zheng-lin LIANG ; Xiu-hua WANG ; Rui NI ; Lan ZHANG ; Uwe MUENSTER ; Shi-rui MAO
Acta Pharmaceutica Sinica 2015;50(9):1180-1185
Using high pressure homogenization method combined with spray-drying, budesonide-loaded chitosan microparticles were prepared and the in vitro release profile was investigated. The microparticles were then blended with lactose using a vortex mixer, influence of mixing speed, mixing time on drug recovery rate and content homogeneity were investigated. Meanwhile, influence of lactose content on drug recovery rate, content homogeneity, powder flowability and in vitro deposition were studied. It turned out that budesonide was released from the microparicles in a sustained manner, with fine particle fraction as high as 46.0%, but the powder flowability was poor. After blending with 10 times of lactose, the drug recovery rate was 96.5%, with relative standard deviation of drug content 2.5%, and fine particle fraction of the formulation increased to 59.6% with good flowability. It's demonstrated that using a vortex mixer, budesonide sustained-release dry powder for inhalation with good recovery and content homogeneity could be prepared, the formulation had good flowability and was suitable for pulmonary inhaling.
Administration, Inhalation
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Budesonide
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chemistry
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Chemistry, Pharmaceutical
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Chitosan
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Delayed-Action Preparations
;
chemistry
;
Drug Carriers
;
Lactose
;
chemistry
;
Particle Size
;
Powders
10.Analysis of tongue figure features in 990 cases of sexually transmitted and intravenous drug use spread HIV infected population in Xinjiang.
Ying ZHANG ; Jian-Ping MA ; Xiu-Lan MA ; Lin ZENG ; Aihemaiti ABUDUREYIMU ; Jing-Ru LI
Chinese Journal of Integrated Traditional and Western Medicine 2014;34(7):816-818
OBJECTIVETo investigate the tongue manifestation features of sexually transmitted and intravenous drug use spread HIV infected population in Xinjiang.
METHODSRecruited were 990 HIV infected subjects in Xinjiang from May 2011 to March 2012, who were assigned to the intravenous drug use spread HIV infected (498 cases) and the sexually transmitted (492 cases). By using tongue figure shoot combined with analyses of experts, tongue manifestations were analyzed and compared between the sexually transmitted and the intravenous drug use spread from four aspects, i.e., the tongue color, the tongue shape, the fur color, and the fur property.
RESULTSCompared with the sexually transmitted population, red tongue, fissured tongue, yellow fur, thick fur, eroded fur, deficiency of fur fluid were more often seen, showing statistical difference (P < 0.05). Compared with the intravenous drug use spread population, pale tongue, white fur, and thin fur were more often seen, showing statistical difference (P < 0.05).
CONCLUSIONSThe tongue manifestations of the intravenous drug use spread HIV population reflected inner exuberance of evil toxin and heat impairing qi and yin. Compared with the intravenous drug use spread population, the attack of HIV infection was more hiding in the sexually transmitted population, with milder internal injury. Their Wei-qi was not damaged and no obvious change occurred in the tongue figure.
Adolescent ; Adult ; Aged ; Female ; HIV Infections ; diagnosis ; etiology ; pathology ; Humans ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Sexually Transmitted Diseases, Viral ; diagnosis ; pathology ; Substance-Related Disorders ; complications ; diagnosis ; Tongue ; pathology ; Young Adult