Background:The incidence of ulcerative colitis( UC)has increased obviously in recent years and is different among different areas and nationalities. Aims:To investigate the clinical features of UC in Kashi Uygur nationality. Methods:A retrospective analysis was conducted based on general condition, clinical type, disease severity, sites of lesion, complications and treatment on patients with UC who were enrolled from February 2003 to February 2012 at the Second Hospital of Kashi Area. Results:One hundred and twenty-six eligible subjects were enrolled in this study. The ratio of male to female was 1. 03: 1(64/62). UC occurred commonly in youth(48. 4%). Chronic relapsing UC was the common clinical type(50. 0%). Most patients were with moderate or severe disease(83. 3%). Lesions of UC were commonly located in left hemicolon( 45. 2%). Incidence of complication was low( 4. 8%). Medical treatment was the main treatment. Conclusions:In Kashi Uygur nationality,the incidence of UC is not significantly different between male and female. UC commonly occurs in youth,chronic relapsing UC is the common clinical type,most patients are with moderate or severe disease,lesions of UC are commonly located in left hemicolon,the incidence of complication is low and medical treatment is the main treatment.