The majority patients of differentiated thyroid carcinoma (DTC) with indolent progression have general good prognosis after standard primary treatments including surgery, thyroid stimulating hormone (TSH) suppression and radioactive iodine (RAI) therapy. However, there are still some patients suffered from recurrence or distant metastasis after initial treatment. They may lose the ability of uptaking iodine during their natural course of disease or treatment and could not benefit from subsequent RAI treatment, which will result in radioiodine-refractory differentiated thyroid cancer (RAIR-DTC). Options are very limited for RAIR-DTC patients, which is associated with a poor prognosis. Recently, with the research advances on the molecular mechanism of RAIR-DTC, redifferentiation combined with RAI therapy have been increasingly used to treat RAIR-DTC, and some outcomes are quite encouraging. This paper reviews the progress of signaling pathway inhibitors, histone deacetylase inhibitors, DNA methyltransferase inhibitors, retinoids and peroxisome proliferator-activated receptor agonists in redifferentiating therapy of RAIR-DTC.

Objective To explore the application effect of SmartTrack Traceability Management System in operation room and the sterilization supply center in our hospital .Methods The smarttrack traceability management system was used in Zhejiang Provincial People′s Hospital on November 16th, 2015, and combined with quick response code (QRC) technique and the artificial intelligence (AI) voice guide, the System had been used in the instruments sterilization , disposable medical consumables management , items sending and receiving, and the achievements of working personnel , etc.Incomplete recycling rate of instruments , packaging miss, labels error, instrument management and satisfaction degree of working staff were compared . Results Before using the system , the incomplete recycling rate of instruments was 4.0%, the packaging miss rate was 2.5%, and the incorrect rate of the labeling was 3.5%; after using the system , they were all significantly reduced ( P<0.05 ) .The average checking time of per-package was ( 6.10 ±0.35 ) s, and it decreased to (0.10±0.13) s after using the system (t=276.00,P<0.01).Employee satisfaction before and after the use of system were 98.6%and 99.3%( P>0.05) .Conclusions The tracking system realizes quickly trace management , and provides a strong guarantee for the security work of operation room and sterilization supply center.