Objective To study the expression of E-cadherin protein and Snail protein in the labial glands of patients with primary Sj(o)gren's syndrome(pSS) and to analyze their roles in the pathogenesis of pSS.Methods The expression of E-cadherin protein and Snail protein were detected by immunohistochemical method.The labial glands were obtained from 50 patients with pSS and 30 healthy controls.The data was analyzed by Chi-Square test,Fisher's exact probability and Spearman's rank correlation analysis.Results The expression rate of E-cadherin in the labials gland of the patients with pSS were lower than that in normal salivary tissues (x2=14.651,P＜0.01).The positive rates of Snail in the labial glands of the patients with PSS were 40％ and it's expression rates were significantly higher than those in normal salivary tissues (x2=28.800,P＜0.01).There was a negative correlation between lymphocyte focus score and the expression of E-cadherin (P＜0.01) and a positive correlation between lymphocyte focus score and the expression of Snail in pSS group (P＜0.01).There was a negative correlation between the expression of E-cadherin and Snail (rs=-0.484,P＜0.01).Conclusion The interaction of E-cadherin and Snail may have played an important role in the pathogenesis of PSS.

Objective To find out and understand the feeling of caregivers who had children with asthma in order to provide proper family-care contents and develop individual nursing care by medical professionals.Methods Totals of fifteen parents of children with asthma were interviewed with open-ended questions.The data collected from the interviews were analyzed with Colaizzi.Results These parents had complex feeling after the asthma diagnosis and desired for social,medical,family support.Disease management difficulties and its negative impact were found in the study.Conclusions These caregivers undergo the psychological and physiological burden and suffered many difficulties and negative effects in asthma management.Health professionals should provide individual nursing care and establish better support system to help them cope with stress.