Objective:To observe and analyze therapeutic effect of noninvasive positive pressure ventilation (NPPV) on aged patients with acute left heart failure in our hospital . Methods:A total of 128 aged patients with acute left heart failure were randomly divided into routine treatment group (n=65 ,received routine emergency drug therapy ) and NPPV group (n=63 ,received NPPV treatment based on routine treatment ) .Clinical symptoms and signs were observed and recorded in two groups ,including partial pressure of oxygen in artery (PaO2 ) ,blood pressure (BP) ,respiratory rate (RR) and heart rate (HR) .According to ECG results and combined with clinical symptoms and signs ,therapeutic effects were comprehen‐sively evaluated and compared between two groups . Results:Compared with routine treatment group ,there was significant rise in PaO2 [ (92.5 ± 7.3) mmHg vs . (106.1 ± 4.8) mmHg] ,significant reductions in BP [systolic blood pressure/dias‐tolic blood pressure ,(142.1 ± 9.2) / (97.2 ± 4.2) mmHg vs . (128.2 ± 4.1) / (89.2 ± 8.1) mmHg] ,, RR [ (27.3 ± 2.8) times/min vs . (16.3 ± 3.3) times/min] and HR [ (113.3 ± 9.3) beats/min vs . (94.2 ± 8.6) beats/min] in NPPV group ,P<0.05 all .Total effective rate of NPPV group was significantly higher than that of routine treatment group (98 . 4% vs .75 . 4% ) , P=0. 009 . Conclusion:Noninvasive positive pressure ventilation can rapidly raise PaO 2 ,relieve symp‐tom in patients with acute left heart failure ,and it is worth extending .

Objective: To explore influence of ginsenoside Rg1 on coronary artery angiogenesis in rats with acute myocardial infarction (AMI) and its mechanism.Methods: A total of 120 Wistar rats were randomly and equally divided into sham operation group (only received thoracotomy to expose heart without coronary ligation),AMI group (no treatment after model development with ligating left coronary artery) and ginsenoside group (received ginsenoside Rg1 injection on 3h after AMI model development).Infarct area, expressions of vascular endothelial growth factor (VEGF) and its receptor (Flk-1), and VIII factor expression were respectively measured on 24h, one week and five weeks after model development.Results: Compared with sham operation group after five weeks, there were significant rise in myocardial infarction area, number of new blood capillaries and expression levels of VEGF and its receptor Flk-1 in ginsenoside group and AMI group, P<0.05 or <0.01;compared with AMI group, there was significant reduction in myocardial infarction area [(51.31±9.67)% vs.(29.33±6.70)%], and significant rise in number of new blood capillaries [(18.31±5.07) vs.(46.79±13.67)], expressions of VEGF [greyscale value: (84.3±8.7) vs.(32.9±16.7), greyscale value was inversely proportional to expression] and Flk-1 [(17.6±8.7) vs.(59.9±16.2)] in ginsenoside group, P<0.05 or <0.01.Conclusion: Application of ginsenoside Rg1 in AMI rat model can mobilize marrow stem cells gather in ischemic myocardium, upregulate expressions of VEGF and its receptor Flk-1, effectively promote angiogenesis of blood capillaries, and reduce myocardial infarction area.