Forensic autopsy is an important link in the medicolegal expertise and the foundation and prerequisite to ensure the quality of the medicolegal expertise.Although there is a rarticularity for each au- topsy case,it is the basic requirement to make great effort to do comprehensive and systcmatic autopsy. The limited definition of comprehensive and systemic autopsy is referred to the examination not only in the cranial,thoracic and abdominal cavitv,but also in special sites such as spinal cavity and peripheral nerve if necessary.The general definition of it includes both the aforementioned examination and the collection and preservation of the proper,adequate and reliable samples and material evidences.The common failures are as follows:①The detail of a case is not clear that leads to wrong plan of autopsy.②The blind autopsy be- cause insufficient preparation.③The examination is lopsided as the partial autopsy.④The operation of autopsy is not conformed to the operational standard.⑤A careless observation causes the omission of intop- sy and pathological changes.⑥The examinational description is not accurate and the records and pictures of autopsy are not clear.⑦Material evidences and samples collected are not suitable to show the truth of the autopsied case.

Talent introduction is of great significance for the development of universities and for the raising of the academic standards.Talent introduction in general includes three links,namely,planning,the policy supporting and the concrete implementation.In the supporting policies of the talent introduction various relations should be properly handled,such as the new talents and the old talents relations,the relationship between the introduction and cultivation and the relationship between the high-level personnel and the conventional talents.

Objective Study the expression of endothelin(ET) of ischaemic myocardium in rat. Method Sixty Wistar rats were randomly divided into 5 groups: coronary artery simply-ligated group,drug-pre-treated group(Isoproterenol,Pituitrin),coronary atherosclerotic group,sham-operated group(as control group). The samples were cut at 15min,30min,45min,60min,90min,120min after coronary (left anterior descending) ligation, and stained with HE and strept avidin-biotin enzyme complex(SABC)method. Results The expression of endothelin was observed with light microscope. Ischaemic myocardium showed ET-positive staining at the early stage of acute myocardial ischaemia in different groups and more in the pre-treated group. Conclusion the SABC-ET method may provide a new marker for diagnosing early myocardial ischaemia, which will be helpful in confirming the cause of sudden coronary death(SCD).

Quantity evaluation is one of inspiring means, whose essence is to put into practice the effective external stimulation for inner motivation.Its purpose is to inspire potential, to bring all people's best into full play and to raise the performance of employees. The process of quantity evaluation is also the process of developing employee's potential.Besides quantity evaluation is good for judgement and examination of the title of technical post, in favor of outstanding personnel shaping, optimization and collocation of human resources. This will make personnel management work more scientific and standardized.

This paper reports the results of forensic pathological study of 128 autopsycases of sudden coronary death(SCD).The severity of the coronary arterystenosis was 4 degree in 63 cases,3 degree in 26 cases and 2 degree in 39 cases.The distribution of the artheroscleorosis of 3 and 4 degree was quite extensive. Recent thrombosis in CA was found in 18 cases,hemorrhage in plaques in 17cases.Only 2 cases had acute myocardial infarction.Inflammatory cell infil-tration were found in coronary plaques in 36 cases.Myocardail fibrosis orsmall scar formation were detected in 56 cases.It is suggested that SCD isthe commonest cause of sudden unexpected death.The majority of SCD(61%)were manhood in middle age.Most cases died suddenly during sleep withoutany clear inducements.The characteristics of the pathological changes in theCA and myoc ardium and the pathological diagnosis of SCD were analyzedand discussed.

Myoglobin (Mb)depletion from myocardium in the cases of sudden soronary death (SCD) and was firstly studied by an immunhistochemial technique (ABC method) in China. Mb was detected quantitatively using scanning microscope photmeter and the results were analyzed statistically by computer The results showed that there were marked depletion of Mb from myocardium in each case of SCD The Mb depleted arce were multiple, disseminatly and segmentally distributed while no depletion of Mb from myocardium in the cases of control group was seen We suggested that the depletion of Mb can be used as one of the diagnostic criterion in the cases of SCD.

ObjectiveTo explore clinical,histopathological and genetic features in a case of fatal familial insomnia (FFI) and related literatures were reviewed. Methods The clinical features in one patient with FFI were analyzed,and the dead patient was examined at autopsy and histopathological studies were performed on the brain tissues; and the blood samples from the patient and some of her familial members were collected for the sequencing of prion protein gene (PRNP). Results The main clinical features included intractable insomnia,psychiatric symptoms and abnormal night sleep behavior,unsteady gait,difficulty swallowing,sudden death,and positive family history. The pathological studies showed multiple neuronal loss and gliosis of brain tissues from the proband,predominated in thalamus; and analysis of PRNP revealed gene D178N mutation,and linkage with 129 methionine (Met) allele in the proband and a relative.ConclusionsFFI patients may manifest as sudden death,and may have prominent psychiatric symptoms; the corresponding gene mutation could occur in the asymptomatic carriers; the data of autopsy and brain tissue pathology is helpful for further understanding of this disease.

As a core curriculum of forensic medicine,it is of great importance to improve the quality of forensic toxicological education for cultivating high-quality forensic professionals.Basing on the rich experiences of forensic teaching and expertise,well teaching effects were achieved by the reform and explorations in teaching contents and methods,development of curriculum and teachers as well as other aspects aimed to improving the quality of forensic toxicological teaching.

Objective To explore a method of forensic identification work in the non-linear length of the plane. Methods 10 soldering tin wires with different lengths were cut out accurately and the results were read as a control (direct reading method of steel ruler). Then the ten soldering tin wires with different lengths were randomly bent and then calculated by the method studied in this paper The length as a Pixel group, and two sets of data for statistical analysis. Results The difference between the results obtained by the Pixel method and those directly read by the ruler direct reading method was not statistically significant. Conclusion The Pixel method has obvious advantages over the traditional cotton method in measuring the non-linear length of the plane (such as scars and wounds). The calculated length is more accurate and easy to operate, making the forensic identification more accurate and convincing Adapt to the requirements of litigation, forensic identification in the good prospects.

OBJECTIVETo compare the curative effect of imatinib and allogeneic hematopoietic stem cell transplant (allo-HSCT) in the treatment of chronic myeloid leukemia (CML).

METHODS292 CML patients received imatinib, and 141 patients underwent allo-HSCT. The clinical data of these patients were retrospectively analyzed to compare event- free survival (EFS) and overall survival (OS) between these two groups of patients in chronic and advanced (including accelerate and blast) phases.

RESULTS(1) EFS, OS, expected 5- year EFS and OS of imatinib group (278 patients in chronic phase) were all statistically higher than of allo-HSCT group (120 patients in chronic phase) (88.5% vs 70.0%, 93.2% vs 80.0%, 84.0% vs 75.0% and 92.0% vs 79.0%, respectively, all P values < 0.01). (2) EFS and OS of imatinib group (14 patients in accelerate and blast phases) were 42.9% and 42.9%, respectively. Meanwhile EFS and OS of allo-HSCT group (21 patients in accelerate and blast phases) were 47.6% and 57.1%, respectively. There were no significant differences in terms of EFS and OS between the two groups (P values>0.05).

CONCLUSIONEFS and OS of imatinib group were significantly higher than of allo-HSCT group for CML patients of in chronic phase. Imatinib and allo-HSCT had the similar efficacy for CML patients in accelerate and blast phases.

Adolescent ; Adult ; Aged ; Benzamides ; therapeutic use ; Child ; Child, Preschool ; Disease-Free Survival ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; therapy ; Male ; Middle Aged ; Piperazines ; therapeutic use ; Protein Kinase Inhibitors ; therapeutic use ; Pyrimidines ; therapeutic use ; Retrospective Studies ; Transplantation, Homologous ; Young Adult