1. Clinical value of anti-liver/kidney microsomal-1 antibody in patients with liver disease
Ying HAN ; Huiping YAN ; Huiyu LIAO ; Limei SUN ; Yunli HUANG ; Chunyang HUANG ; Haiping ZHANG ; Xiaodan ZHANG ; Xinqu BIAN ; Meixin REN ; Xiaofei DU ; Yanmin LIU
Chinese Journal of Hepatology 2017;25(11):852-857
Objective:
To investigate the clinical and laboratory features of patients with liver disease and positive anti-liver/kidney microsomal-1 (anti-LKM-1) antibody, and to provide a reference for clinical diagnosis and differential diagnosis.
Methods:
The clinical data of patients with positive anti-LKM-1 antibody who were treated in our hospital from 2006 to 2016 were collected, and clinical and laboratory features were analyzed and compared. An analysis was also performed for special cases.
Results:
The measurement of related autoantibodies was performed for about 100 thousand case-times, and 15 patients were found to have positive anti-LKM-1 antibody. Among the 15 patients, 7 were diagnosed with type 2 autoimmune hepatitis (AIH) with an age of 11.0 ± 9.0 years and were all adolescents with acute onset; 8 were diagnosed with hepatitis C with an age of 51.5 ± 9.0 years, among whom 7 were middle-aged patients and 1 was a child aged 12 years, and all of them had an insidious onset. Compared with the patients with hepatitis C, the AIH patients had significantly higher levels of alanine aminotransferase (1 003.9 ± 904.3 U/L vs 57.0 ± 84.1 U/L,