Objective:To investigate the psychosocial factors of women with menopausal depression and to study their preventive measures.Methods:From July 2016 to December 2018, 150 patients with climacteric depression who admitted to the Third People's Hospital of Huzhou were selected as the study group, and 150 healthy women during the same period were selected as the control group.The psychosocial factors of the two groups were investigated and compared, and the preventive measures were studied.Results:The total scores of the Symptom Checklist (SCL-90), the number of positive items and their average scores in the study group[(174.41±38.32)points, (38.94±18.21)points, (3.22±0.49)points] were significantly higher than those in the control group[(155.09±48.50)points, (30.08±20.20)points, (2.92±0.56)points], the scores of the 9 factors in the study group were significantly higher than those in the control group, and the differences were statistically significant ( t=2.271, 2.212, 2.290, 2.133, 2.112, 1.970, 3.602, 3.425, 2.104, 1.951, 2.093, 2.146; P=0.038, 0.030, 0.022, 0.017, 0.017, 0.018, 0.006, 0.004, 0.015, 0.015, 0.013, 0.012). The neurotic (P) and internal and external (E) dimension scores of the study group[(6.83±2.36)points, (9.53±5.64)points] were significantly lower than those in the control group[(7.78±3.27)points, (14.21±5.31)points], the differences were statistically significant ( t=1.203, 4.313; P=0.021, 0.002). The emotional stability (N) and occlusion (L) dimension scores of the study group[(13.39±6.01)points, (10.80±4.31)points] were significantly higher than those of the control group[(7.20±2.11)points, (6.39±2.69)points], the differences were statistically significant ( t=6.896, 6.210; P=0.007, 0.004). The total score of social support[(31.66±4.61)points] in the study group was significantly lower than that in the control group[(36.75±4.79)points], the difference was statistically significant ( t=4.97; P=0.003). The scores of total life events and negative events in the study group [(60.61±14.68)points, (39.02±15.27)points] were significantly higher than those in the control group[(32.09±9.20)points, (9.21±4.53)points], the differences were statistically significant ( t=11.396, 12.510; P=0.006, 0.008). Conclusion:Female patients with menopausal depression are closely related to their psychosocial factors, and their mental status is poor, and they are in a sub-health state for a long time.Active and effective psychological interventions for menopausal women can effectively prevent the occurrence of menopausal depression, and thus improve the quality of life and level of menopausal women.

Objective: To explore the effect of horticultural therapy on the rehabilitation of patients with depression in hospital. Methods: A total of 80 cases with depression who met the inclusion criteria were selected from the Third People′s Hospital of Huzhou City from January 2017 to December 2017. We used random-number methods to classify patients into either the intervention group or the control group with 40 cases in each group. While the two groups both received conventional antidepressant drugs, and psychiatric care routine and conventional rehabilitation training. Patients in the intervention group also attended horticultural therapy, the treatment period lasted for 4 weeks. The two groups were measured by HAMD and IPROS to compare the clinical symptoms and rehabilitation effects, the before of the 4th week and the end of the 4th week after treatment. Results: There was no statistically significant difference in HAMD score before the intervention among two groups (P >0.05). The HAMD score in the two group were both lower at the end of the 4th week. However, there was statistically significant difference in HAMD score among the two groups (t=5.458, P <0.01), the score of the intervention group was 12.11±2.76, which was significantly lower than that of the control group 15.54 ±2.86. There was no statistically significant difference in IPROS score between the two groups before treatment (P >0.05). After 4 weeks, there was statistically significant difference in IPROS score of intervention group and control group (t=4.168, P <0.01), the intervention group was 23.92±3.63, which was significantly lower than that of control group 34.85±4.17. Conclusions Horticultural therapy can effectively alleviate the clinical symptoms of patients with depression, promote rehabilitation, and improve social functions.

Objective This study aimed to investigate the effects of P.odoratum extract on lactase activity and microflora diversity in mice with bacterial dysbacteriosis.Methods SPF male BALB/c mice were randomized into 4 groups:control,model,P.odoratum extract low dose(1.56 g·kg-1·d-1)and high dose(3.12 g·kg-1·d-1)treatment group.There were 8 mice in each group(5 in the blank group).In addition to the control group,after 7 days of intragastric administration of mixed antibiotics,the administration groups were given P.odoratum extract for 7 days,and the control group and the model group were given the same amount of sterile water.The changes of diarrhea,body weight and food intake of mice were recorded.The colon HE staining sections,ZO-1 protein,IL-6 expression,and serum LPS concentration were detected.Feces were collected for lactase activity and microbial diversity determination with 16S rRNA high-throughput sequencing technology.Results After 7 days of antibiotic intervention,compared with the control group,the mice in the model group had soft stool,weight loss,reduced food intake,and significantly reduced intestinal flora diversity.At the 14th day,in the model group,ulceration accompanied by slight interstitial congestion and edema was seen in the colon,ZO-1 expression was significantly reduced,IL-6 expression was significantly increased,serum LPS was significantly increased,lactase activity was significantly reduced,and intestinal flora diversity was still lower compared with the control group.After 7 days of administration,compared with the model group,P.odoratum reduced the diarrhea rate of mice,promoted a recovery of body weight and food intake,downregulated pathological colon tissue damage,significantly increased ZO-1 protein expression,and reduced colon factor IL-6 and serum LPS concentration.In addition,P.odoratum can significantly up-regulate lactase activity and improve the community richness and diversity of dysbacteriosis mice.It is shown that three phyla(up-regulated Firmicutes,down-regulated Proteobacteria and Bacteroidetes)and seven genera(up-regulated Rikenellaceae_RC9_gut_group,Rikenella,Colidextribacter,norank_f__Lachnospiraceae,norank_f__Oscillospiraceae,and Lachnospiraceae_NK4A136_group,down-regulated Alloprevotella),the abundance of which was significantly correlated with body weight and lactase activity,serum LPS,and colon factor IL-6.Conclusion P.odoratum can alleviate the gut barrier injury and dysfunction caused by antibiotic induced dysbiosis,and its mechanism may be achieved by regulating microflora structure.