Objective To investigate the clinical efficacy of fasudil hydrochloride combined with mannitol on the treatment of the patients with cerebral edema after brain tumor operation. Methods In this study, 76 patients with brain edema after brain tumor operation from May 2015 to October 2016 were were divided into the control group and the observation group according to different administration, 38 cases in each group.The control group was treated with mannitol and the observation group was treated with fasudil hydrochloride combined with mannitol. Comparison of the two groups of treatment efficiency, neurological score, brain edema area and adverse reactions. Results The total effective rate 97.37% in the observation group was significantly higher than 78.95% in the control group(P<0.05).The level of neurological function was (10.05 ± 1.78) points and brain edema was (21.06±2.51) cm3in the observation group which were significantly lower than those in the control group (13.36±2.02), (27.09 ±3.75) cm3(P<0.05). The incidence of adverse events (2.63%) in the observation group was not significantly different from that in the control group (5.26%). Conclusion The effect of fasudil hydrochloride combined with mannitol on cerebral edema after brain tumor operation is more remarkable than that of simple treatment, and the brain edema area and neurological function score of patients are reduced. Therefore, the therapeutic regimen can be the recommended for clinical application..

Objective To observe the effect of nimodipine combined with nimodipine on cerebral vascular dementia after cerebral infarction.MethodsFrom February 2009 to March 2012, 32 patients with vascular dementia after cerebral infarction were selected in Beijing Chaoyang hospital.Among them, there were 19 males and 13 females, aged 63~84 years old.The patients were randomly divided into two groups, each group of 16 patients.The patients in the treatment group were treated with oral nimodipine combined with Piracetam Tablets.ResultsThe effective rate of the treatment group was 93.8%, the adverse reaction rate was 6.3%, while the control group was effective, the adverse reaction rate was 18.8%, the difference between the two groups was significant (P<0.05).ConclusionIn the treatment of patients with vascular dementia after cerebral infarction, the use of nimodipine combined with nimodipine has significant curative effect and less adverse reaction rate, which is worthy of clinical application.

Objective To observe the clinical efficacy of treatment of subarachnoid hemorrhage with Danshen solution combine nimodipine.Methods80 cases diagnosis with subarachnoid hemorrhage from January 2014 to February 2015, were randomly divided into observation group and control group 40cases, observation group were plus conventional therapy Danshen solution treatment, the control group were given nimodipine only conventional treatment, recorded and analyzed before and after treatment S-100B protein in cerebrospinal fluid situation, status and treatment of disease incidence of complications in patients with two groups of patients.ResultsTreatment 5d, 7d, 14d after S-100B protein were observed in patients (0.788±0.014)μg/L,(0.625±0.15)μg/L,(0.501±0.13)μg/L, were better than the control group (0.957±0.16)μg/L,(0.823±0.17)μg/L,(0.711±0.12)μg/L, and the differences were statistically significant (P<0.05).Treatment observation group total effective rate of 90.0%, higher than 67.5%, and the difference was significant (P<0.05).The treatment group rebleeding, cerebral ischemia, hydrocephalus and other complications with the control group fairly, the difference was not significant.ConclusionIt is effective for the treatment of subarachnoid hemorrhage withdanshen solution combine nimodipine, can significantly improve the cure rate in patients with subarachnoid hemorrhage, reducing mortality.It is worthy of further research and applications.

Objective To explore the microsurgical method in treating ruptured aneurysms treatment and evaluating the treatment of the complication during or after the operation.Methods 36 cases of patients with intracranial aneurysm were analyzed retrospectively.All of the patients were subarachnoid hemorrhage (SAH) by CT scan on admission.The intracranial aneurysms were confirmed in 35 cases by DSA examination and A2 aneurysm was confirmed by explorative operation in 1 case.The microsurgical treatment was performed in 36 cases at the early or intermediate stage,22 cases were treated in the early stage,the other 14 cases were treated in the intermediate stage (early stage means within 3 days post SAH;intermediate stage means from 4 days to 10 days post SAH).Results After the operation,21 cases were GOS grade Ⅰ,4 cases were COS grade Ⅱ,4 cases were COS grade Ⅲ,4 cases were GOS grade Ⅳ.Of all the patients,CT scan was done after the operation,finding no intracranial bemorrhage,and cerebral infarction was disclosed in 5 cases.3 cases were dead,one suffered occipital lobe infaret after the PCoA aneurysm clipped,brain hernia occurred at last,one's Hunt Hess grade was Ⅴ,ACoA aneurysm was disclosed by DSA examination,severe brain edema occurred after the operation,the other suffered tonsillar hernia one week after the aneurysm clipping,which ruptured after endovascular treatment of ACoA aneurysm 2 years later.DSA examinations were done in 26 cases after operation,declaring 1 ACoA aneurysm was unclipped,1 PCoA aneurysm was incompletely clipped,and 1 PCoA was sacrificed.Conclusions It is a valuable method to clip the ruptured intracranial aneurysms in early and intermediate stage.The cerebral ischemia is the severe complication after clipping.Especially for the PCoA aneurysms,it is very important to protect the PCoA.Further research should be done for the treatment in the case with mother artery arteriosclerosis and thrombosis within the aneurysms.

ObjectiveTo construct traditional Chinese medicine （TCM） diagnostic scale of turbid toxin syndrome in order to provide corresponding reference for the standardization of TCM syndromes and studies. MethodsWe systematically searched the Chinese Medical Dictionary （CMD）， China Knowledge Network （CNKI）， Wanfang Data Knowledge Service Platform （WF） and VIP database for TCM classics and modern literature on turbid toxin syndrome， and initially screened the four diagnosis information of turbid toxin syndrome， established a pool of information entries， and conducted a cross-sectional clinical survey. Discrete trend method， correlation coefficient method， Cronbach's coefficient method， and factor analysis method were applied to objectively screen the entries. The diagnostic scale of turbid toxin syndrome were constructed through three rounds of Delphi method expert survey to determine the scale entries， using hierarchical analysis to get the judgement matrix scores and relative weight of each entry， after passing consistency test and then isometric expansion of the relative weight of the entries to get the weight of each entry and assign the value. ResultsA total of 35 articles were included， 45 entries were obtained after the initial screening. After the clinical investigation， 12 entries were not suitable by the discrete trend method， 23 entries not suitable by correlation coefficient method， 13 entries by the internal consistency screening were removed with the Cronbach's alpha coefficient rising， and 10 entries not suitable by the factor analysis method. Twenty-two entries were retained after objective screening by the combined use of the four statistical methods. The positive coefficients of experts in the three rounds of Delphi method of expert consultation were 96.67%， the coefficients of expert authority were 0.834， 0.856， and 0.867， and the coefficients of co-ordination were 0.126， 0.326， and 0.312， respectively. After consulting with clinical experts， and three rounds of Delphi method survey and hierarchical analysis method weight assignment， the diagnostic scale entries of turbid toxin syndrome were finally established. Primary symptoms： dark red or purple and dusky tongue， yellowish greasy or dry coating （10 points）； sticky and unpleasant stools （8 points）； disharmony of tastes including halitosis， sticky and greasy taste in the mouth， dry mouth and bitter taste in the mouth （6 points）； unfavourable or yellowish or red urination （5 points）； and dark complexion （4 points）. Secondary symptoms： heavy body （3 points）； dizziness （3 points）； profuse， sticky， foul-smelling secretions （2 points）； wiry and slippery， or slippery， or slippery and rapid pulse （2 points）； feeling of hardness in the abdomen （1 point）. ConclusionUsing Delphi method combined with the hierarchical analysis method， combining qualitative and quantitative study， a diagnostic scale of turbid toxin syndrome was initially developed.

Humans ; Staphylococcus lugdunensis/genetics* ; Peptides, Cyclic ; Chromosomes ; Operon/genetics* ; Staphylococcal Infections/genetics* ; Bacterial Proteins/genetics* ; Anti-Bacterial Agents