1.Investigation on Knowledge about Rational Drug Use in 2 419 Inpatients
Wei WANG ; Xinneng BAN ; Zhengyan LIU ; Li JIANG
China Pharmacy 1991;0(06):-
OBJECTIVE:To understand the knowledge about rational drug use(RDU) in inpatients.METHODS:An cluster sampling investigation was carried out by questionnaire at separate times and in separate groups in 2 419 inpatients in the hospital where the authors work. RESULTS:The majority of the inpatients were concerned much with the drug use,but lacked the knowledge about RDU and had much misunderstanding about drug use.CONCLUSION:The relevant measures must be taken to guide the RDU in patients and to improve the understanding of RDU.
2.Relationship between Line 1 methylation and clinical data of non-small cell lung cancer.
Xinneng LIU ; Yongtang JIN ; Peiwei XU ; Chunmei CHEN ; Cong TAN
Chinese Journal of Medical Genetics 2014;31(3):307-311
OBJECTIVETo explore the impact of Line-1 methylation on clinical features of non-small cell lung cancer and its connection with smoking and other living habits.
METHODSPyrosequencing was used to determine the extent of Line-1 methylation in cancer and adjacent tissues derived from 197 patients with primary non-small cell lung cancer. Non-conditional logistic regression analysis was performed to correlate the level of Line-1 methylation with clinical features and living habits of the patients.
RESULTSLine-1 methylation for cancer tissue and adjacent tissue has measured 68.20±11.63 and 78.90±2.09, respectively (P < 0.01), and has been associated with TNM staging, smoking history and histopathological types.
CONCLUSIONLung cancer tissue Line-1 methylation level is closely related with clinical features and smoking. There is also a correlation between histopathological types of lung cancer and relative hypomethylation of Line-1.
Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung ; genetics ; metabolism ; pathology ; DNA Methylation ; Female ; Humans ; Long Interspersed Nucleotide Elements ; Lung Neoplasms ; genetics ; metabolism ; pathology ; Male ; Middle Aged