OBJECTIVE: To investigate the surgical procedure and indication of the Extended supracricoid partial laryngectomy with tracheocricohyoidoepiglottopexy and tracheocricohyoidoglottopexy (ESCPL+-TCHEP/TCHP) as well as the rehabilitation of laryngeal functions. METHOD: ESCPL+TCHEP/TCHP were conducted in 10 cases with laryngeal carcinoma of T3 and T4 stages with subglottic invasion for 10-20 mm from 2000 to 2005. RESULT: All the 10 cases, 9 of them have survived until now and still be followed up. 1 of them succumbed to the recurrence of cervical lymph node metastasis 4 years after the surgery. Normal respiration, deglutition and the function of maintaining subglottic pressure were recovered in all the case. Postoperative phonation was also satisfactory among all of them. CONCLUSION If handle the surgical indication strictly, to some cases of laryngeal carcinoma with subglottic invasion for 10-20 mm, this surgical technique could replace the total laryngectomy.
Aged ; Carcinoma, Squamous Cell ; pathology ; surgery ; Cricoid Cartilage ; surgery ; Humans ; Laryngeal Neoplasms ; pathology ; surgery ; Laryngectomy ; methods ; Larynx ; surgery ; Male ; Middle Aged ; Treatment Outcome

Objective:To explore the effectiveness of 18F-deuterated-Florbetapir (D3FSP) PET/CT imaging in detecting β-amyloid (Aβ) deposition in the brain and its correlation with plasma biomarkers. Methods:A retrospective analysis was conducted on 79 patients (32 males, 47 females; age(66±7)years) who underwent 18F-D3FSP PET/CT imaging from June 2022 to November 2023 at the First Affiliated Hospital, Guangzhou Medical University, as a part of the Greater Bay Area Healthy Aging Brain Longitudinal Cohort Study (GHABS). Based on the Alzheimer′s Disease Neuroimaging Initiative cohort standard protocol, patients were categorized into cognitively unimpaired (CU) group, mild cognitive impairment (MCI) group, and Alzheimer′s disease (AD) group. Brain regions were segmented using the AW workstation and the SUV ratio (SUVR) was calculated with the cerebellum as the reference region. One-way analysis of variance, Bonferroni correction and Pearson correlation analysis were used to analyze data. The ROC curve analysis was used to analyze the cut-off value and the diagnostic efficacy of SUVR. Results:There were 48, 15 and 16 cases in CU, MCI and AD groups respectively. During the transition from CU to MCI and then to AD, there was a rising trend in SUVR ( F values: 11.15-22.38, all P<0.001) across the whole brain and various brain regions (bilateral frontal lobes, bilateral anterior cingulate gyrus, bilateral precuneus, bilateral parietal lobes, bilateral lateral temporal lobes, and bilateral occipital lobes). SUVRs of the right anterior cingulate gyrus and bilateral precuneus were different between the CU and MCI groups (all P<0.017), and those of bilateral frontal lobes, right precuneus, bilateral parietal lobes, bilateral lateral temporal lobes, and bilateral occipital lobes were different between the MCI and AD groups (all P<0.017). SUVRs of brain regions were negatively correlated with cognitive scale scores ( r values: from -0.57 to -0.37, all P<0.001), and were positively correlated with plasma phosphorylated tau181 (p-tau181, r values: 0.50-0.61, all P<0.001). The ROC curve analysis suggested that the cut-off value of SUVR in the precuneus for distinguishing CU from AD was 1.20, with the AUC, sensitivity, specificity and accuracy of 0.85, 12/16, 91.7%(44/48)and 87.5%(56/64), respectively. Conclusion:18F-D3FSP PET/CT imaging has good clinical application value in assessing the deposition sites and the extent of Aβ in the brain, which is related to clinical cognition and plasma p-tau181 level.