Coleus forskohlii oral solution is a composite preparation containing several effective constituents of the plant, such as isoforskolin, 1-acetylforskolin etc.Following ig administration of the oral solution equivalent to≤35 g (raw herb)/kg to mice, neither toxic reaction nor death was observed. After the oral solution 30, 15, 10 g/(kg?d)?60 ig to rats, their appearance, body weight, and hematological, biochemical and pathological investigations were basically normal. In anesthetized rabbits intraduodenally administered the oral solution≤10g/kg, the respiration, airway secretion, blood pressure, ECG and EEG did not change significantly.These results indicate that Coleus forskohlii oral solution is a quite safe preparation.

Today,more and more patients with diabetes are requiring surgical intervention.Not only the metabolic disturbance of carbohydrate will be aggravated by surgical stress,but also the risk of perioperative complications and mortality have been greatly increased in patients with diabetes.Therefore,a complete preoperative assessment and blood glucose management of preoperative,intraoperative,and postoperative periods are needed to get full assurance for diabetic patients to undergo surgery and to pass through the perioperative period smoothly.

Objective:To explore the relationship between the expression of EGFR and STAT3 in human la-ryngeal papilloma and its biological behavior. Method: Reverse transcription polymerasechain reaction(RT-PCR), immunohistochemical staining and Western blot were used to evaluate the mRNA and protein expression of EGFR and STAT3(p-STAT3) in 42 laryngeal papilloma tissues and 15 samples of normal laryngeal tissue, and the rela-tionship between the protein expression of them and clinicpathological parameters was also analysized. Result: The mRNA expression levels of EGFR and STAT3 in laryngeal papilloma tissue were significantly higher than that in normal laryngeal tissue(P<0.05,P<0.01). Protein positive expression of EGFR and p-STAT3 were also detected in a significantly greater proportion of laryngeal papilloma than normal laryngeal tissue by immunohistochemistry and western blot(P<0.01,P<0.05). There was relationship between EGFR and p-STAT3 overexpression in la-ryngeal papilloma(P<0.05). The expression p-STAT3 was correlated with the recurrence and canceration of la-ryngeal papilloma(P<0.05). Conclusion: The EGFR-STAT3 signal transduction pathway may be involved in the pathogenesis of laryngeal papilloma,, and the persistent activation of STAT3 gene plays an important role in the recurrence and canceration of laryngeal papilloma.

Objective To know the experiences of head nurses about year-ending comprehensive check of work. Methods Interviewed 10 head nurses by qualitative study methods, summarized and ana-lyzed their experiences about year-ending comprehensive check of work. Results Five subjects about the year-ending comprehensive cheek of work were summarized, they were questions about the meaning of the check, experiences of the value of the nursing management work, influence of check on emotion, expectation of the head nurses' role and the ideas about future check. Conclusions The related nursing managers should emphasis head nurses' working designation and role, and then increase their working interesting, promote clinical nursing management developing smoothly.

Objective: To ascertain the process conditions for extracting the volatile oil from kangchi Capsules. Methods: The effects of water adding amount and extraction time on the yield of volatile oil were studied. The extraction condition of percolation was established with the extract yield and extraction transfer rate of tanshinone Ⅱ A as markers and the optimum condition for reflux method also was selected with the orthogonal test. Results: The volatile oil of Rhizome Acori Graminei could be basically extracted when it was extracted for 5 hours with 12 times of water. Radix Salviae Miltiorrhizae and Radix Polygalae could be effectively extracted with the peocolation and reflux methods in 90% alcohol as a solvent. But the percolation method used less energy consumption and solvent than refluex method. So the production cost was lowered. Conclusion: The experimental results provide the basis for the ascertainment of extraction process of kangchi Capsules.

Objective To explore the clinical efficacy of hysteroscopic IUD intrauterine surgery for incarcerated ring,and to assess the safety.Methods 586 women with the incarcerated dervice remove under hysteroscope were selected in the hospital (study group),693 women during the same period used conventional methods of taking the dervice (control group ).The status of surgery,cervical relaxation,take the dervice and effect and safety were assessed.Results The operation time,amount of vaginal bleeding and take the dervice time of the study group were (19.36 ±3.14)min,(9.42 ±2.11)mL and (8.17 ±1.90)min,which were lower than those of the control group [(30.29 ±4.08)min,(15.67 ±2.38)mL and (11.35 ±2.26)min],the differences were statistically significant (t=13.16,11.51,9.76,P<0.05).The cervical relaxation goodand take part successfully of the study group were 490 cases(83.62%)and 435 cases(74.23%),which were higher than those of the control group[374 cases (53.54%)and 362 cases(52.24%)],the differences were statistically significant (χ2 =10.28,11.35,P<0.05). Waist lower abdominal pain (0-Ⅰ grade)and vaginal bleeding number (no vaginal flow or<1 day)of the study group were 509 cases (86.86%)and 362 cases (61.77%),which of the control group were 527 cases (76.05%) and 362 (46.23%),and the differences were statistically significant (χ2 =9.94,10.23,P<0.05 ).Conclusion Hysteroscopic IUD intrauterine surgery can shorten the operation time and take the dervice time,reduce the amount of vaginal bleeding and bleeding time.It can improve the success rate of taking the dervice and has fewer negative symptoms.It has high safety and clinical advantages are obvious.

Objective: To trace the content changes of tanshinone ⅡA in the preparing process of Kangchi Capsule. Methods: Exploring the influences of the different extraction, concentration and drying on the extraction efficiency of tanshinone Ⅱ A. Results: The extraction of the percolation with 75% ethanol was better than reflux, drying at 60?C and vacuum distilation was optimum condition. Conclusions: Choosing proper extract, concentration and drying could lower the loss of tanshinone Ⅱ A in the preparing process to a certain extent.

Based on International Classification of Functioning, Disability and Healthy (ICF), this paper discussed the education of exercise rehabilitation in the terms of the goal, knowledge system and practice system. It suggested that the framework of ICF could be used to develop course system. The professional undergraduate education of exercise rehabilitation should include knowledge of rehabilitation medicine, sports science, and skills in modern rehabilitation.

BACKGROUND: Blood vessel remodeling is the basis of the remodeling of orthodontic periodontal tissues. Can He-Ne laser irradiation promote blood vessel remodeling and then accelerate the process of the remodeling of orthodontic periodontal tissues or not?OBJECTIVE: To investigate the effects and action mechanisms of He-Ne laser irradiation on the blood vessel remodeling of orthodontic periodontal tissues of rabbits.DESIGN: Randomized controlled study.SETTING: Animal experimental center of Jilin University.MATERIALS: Thirty-five flap-eared rabbits weighting 2.0 kg were provided by Animal Experimental Center of Jilin University, license No. SYXK(Ji)2002-0002, production license No. SCXK2003-0003. Animal intervention met animal ethical standard. HNGSQ-1 type of He-Ne laser therapeutic instrument was produced in Shanghai. HPIAS-1000 image analytical system was produced by Tongji Medical University. CD34 monoclonal antibody with the product number of MAB-0034 and vascular endothelial growth factor monoclonal antibody with the product number of MS-350 were offered by Fuzhou Maixin Company.METHODS: Experiments were performed at the Provincial Laboratory of Animal Experimental Center of Jilin University from May to December 2003. ①Thirty-five flap-eared rabbits were randomly divided into seven groups, an unforced group and forced 1-, 3-, 5-, 7-, 14- and 21-day groups with 5 rabbits in each group. A stainless steel closing coil spring was deposited between the maxillary first molar and the corresponding maxillary incisor bilaterally, delivering 0.08 N force. The right maxillary of rabbits of each forced group was irradiated by He-Ne laser, and the left side was as control.The cheek corresponding to the right maxillary first molar was selected as irradiation spot and then received He-Ne laser local irradiation. He-Ne laser's wavelength is 632.8 nm, power output of 20.0 mW and energy density of 2.50 J/cm2.Animals of the unforced group did not proceed with anything, sacrificed after raising for a week. Animals of the forced groups were respectively sacrificed on days 1, 3, 5, 7, 14 and 21. ②The premaxillary bones, including the upper first molar, were cut into sagittal sections. Sections were preceded with CD34 and vascular endothelial growth factor immunohistochemical straining. Microvessel density and microvessel area were measured in the tension zone and the pressure zone of orthodontic periodontal tissues. The staining intensity for vascular endothelial growth factor was evaluated by the measurement of gray value using the Computer Image Analyzing System.MAIN OUTCOME MEASURES: ①Gray integral of vascular endothelial growth factor after immunohistochemical staining. ②Microvessel density and microvessel area.RESULTS: Thirty-five rabbits were involved in the result analysis. ①Microvessel density and microvessel area in He-Ne laser irradiated sides were all obviously larger than in the control sides in every forced group in the tension zone and the pressure zone (P ＜ 0.05-0.01), except for the 1-day group. ②In the 1-day group, the vascular endothelial growth factor expressions in periodontal tissues in pressure zone of He-Ne laser irradiated sides were significantly lower than that of control sides (P ＜ 0.05). In the 3- and 5-day groups, vascular endothelial growth factor expressions in pressure zone of irradiated sides were significantly higher than that of control sides (P ＜ 0.05). The vascular endothelial growth factor expressions in pressure zone of both irradiated sides and control sides reached a peak at 5-day group. The vascular endothelial growth factor expressions of irradiated sides were significantly higher than the corresponding control sides in tension zone at 3-, 5- and 7-day group (P ＜ 0.05). The vascular endothelial growth factor expressions in tension zone of both irradiated sides and control sides reached a peak at 14-day group.CONCLUSION: He-Ne laser irradiation promotes blood vessel remodeling of periodontal tissues, increases the vascular endothelial growth factor concentrations in periodontal tissues and makes the angiogenesis of periodontal tissues more active, followed by the remodeling of orthodontic periodontal tissues.

Objective To observe the clinical efficacy of puerarin injection combined with levodopa in the treatment of Parkinson. Methods 126 Parkinson patients were grouped into two groups randomly. Control group was treated with levodopa and observation group was added to Gegensu injection. Results 3 months later, UPDRS scale score, ADL and HAMD score of observation group were lower than that of control group(P<0.05).Serum Hcy and plasma hs-CRP level of observation group were lower than that of control group( P<0.05).Adverse reactions of observation group was 6.35％ during treatment, compared with the control group 9.52％ had no significant difference. Conclusion Gegensu injection can help improve cognitive ability and improve self-care ability in patients with Parkinson, alleviate symptoms and medication safety.